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acy-2 acy-2 aldo-2 aldo-2 acy-1 acy-1 lin-3 lin-3 egl-4 egl-4 kin-2 kin-2 acy-4 acy-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
acy-2Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1080 aa)
aldo-2Fructose-bisphosphate aldolase 2. (366 aa)
acy-1Adenylyl CYclase. (1253 aa)
lin-3Protein lin-3; Probable ligand for tyrosine kinase receptor let-23. Essential for vulval induction, where it acts downstream of the synthetic multivulva (synMuv) class genes. Probably by activating let-23, phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade, plays a role in ovulation by promoting gonadal sheath cell contractions and spermatheca dilatation during ovulation. Probably by regulating neuronal transmission in ALA neurons, mediates the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, by [...] (477 aa)
egl-4cGMP-dependent protein kinase egl-4; Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor. Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2. Represses body size and lifespan through the dbl-1 and insulin pathways, respectively. May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility. Regulates behavioral responses to various chemosensory stimuli in sensory neu [...] (783 aa)
kin-2cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. (376 aa)
acy-4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1013 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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