STRINGSTRING
dmdA_2 dmdA_2 rlmCD_1 rlmCD_1 CUN34494.1 CUN34494.1 gltD_1 gltD_1 csdA csdA CUN38463.1 CUN38463.1 hcp_1 hcp_1 thiC thiC nadA nadA CUN43226.1 CUN43226.1 porA porA sdhA_1 sdhA_1 sdhB_1 sdhB_1 rlmCD_2 rlmCD_2 nreB nreB CUN56616.1 CUN56616.1 CUN58064.1 CUN58064.1 rlmN rlmN purF purF CUN62763.1 CUN62763.1 nrdG nrdG pyrK_1 pyrK_1 gltD_2 gltD_2 frdB frdB CUN71490.1 CUN71490.1 CUN71535.1 CUN71535.1 CUN73245.1 CUN73245.1 pflA_1 pflA_1 dmdA_1 dmdA_1 ilvD ilvD hemN hemN CUN84904.1 CUN84904.1 sir sir moaA moaA nifH1_1 nifH1_1 nifH1_2 nifH1_2 hemZ hemZ CUN89516.1 CUN89516.1 CUN90196.1 CUN90196.1 CUN90569.1 CUN90569.1 CUN90616.1 CUN90616.1 pflA_2 pflA_2 hgdC_1 hgdC_1 ispG ispG nifS nifS nifU nifU hgdC_2 hgdC_2 miaB_1 miaB_1 CUO01931.1 CUO01931.1 CUO03041.1 CUO03041.1 hacA hacA thiH thiH pyrK_2 pyrK_2 addB addB rpsA rpsA CUO09454.1 CUO09454.1 rimO rimO pflA_1-2 pflA_1-2 CUO13514.1 CUO13514.1 CUO13577.1 CUO13577.1 sdhB_2 sdhB_2 sdhA_2 sdhA_2 bioB_1 bioB_1 hcrC hcrC hgdC_3 hgdC_3 mutY mutY pdg pdg CUO26070.1 CUO26070.1 rnfC rnfC rnfB rnfB CUO37566.1 CUO37566.1 CUO38330.1 CUO38330.1 miaB_2 miaB_2 iscS iscS CUO39603.1 CUO39603.1 hpdA hpdA gltD_3 gltD_3 gltB gltB queE queE ydeM ydeM ypfD ypfD yccM yccM ttdA ttdA bioB_2 bioB_2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dmdA_22%2C3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (414 aa)
rlmCD_123S rRNA (uracil-C(5))-methyltransferase RlmCD; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (452 aa)
CUN34494.1Iron hydrogenase 1. (570 aa)
gltD_1Glutamate synthase [NADPH] small chain. (610 aa)
csdA4-hydroxyphenylacetate decarboxylase activating enzyme. (305 aa)
CUN38463.1Ferredoxin. (56 aa)
hcp_1Hydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (535 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (433 aa)
nadAQuinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (302 aa)
CUN43226.1Antiporter inner membrane protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (274 aa)
porAPyruvate synthase subunit porA. (1173 aa)
sdhA_1L-serine dehydratase%2C alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (287 aa)
sdhB_1L-serine dehydratase%2C beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (222 aa)
rlmCD_223S rRNA (uracil-C(5))-methyltransferase RlmCD; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (459 aa)
nreBOxygen sensor histidine kinase nreB. (440 aa)
CUN56616.1Radical SAM protein. (305 aa)
CUN58064.1Anaerobic sulfatase-maturating enzyme. (370 aa)
rlmNRibosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (343 aa)
purFAmidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (475 aa)
CUN62763.1Anaerobic sulfatase-maturating enzyme. (368 aa)
nrdGAnaerobic ribonucleotide reductase-activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (162 aa)
pyrK_1Dihydrdoorotate oxidase B%2C electron transfer subunit. (273 aa)
gltD_2Glutamate synthase [NADPH] small chain. (463 aa)
frdBFumarate reductase iron-sulfur subunit. (233 aa)
CUN71490.1Probable DNA metabolism protein. (249 aa)
CUN71535.1Putative DNA modification/repair radical SAM protein. (497 aa)
CUN73245.1Uncharacterized BCR%2C COG1636. (213 aa)
pflA_1Pyruvate formate-lyase-activating enzyme. (250 aa)
dmdA_12%2C3-dimethylmalate dehydratase large subunit. (759 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (554 aa)
hemNOxygen-independent coproporphyrinogen-III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (383 aa)
CUN84904.1Uncharacterised protein. (230 aa)
sirSulfite reductase [ferredoxin]; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (514 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (319 aa)
nifH1_1Nitrogenase iron protein 1. (253 aa)
nifH1_2Nitrogenase iron protein 1. (253 aa)
hemZOxygen-independent coproporphyrinogen-III oxidase 2. (476 aa)
CUN89516.1Uncharacterised ACR%2C YkgG family COG1556. (212 aa)
CUN90196.1CRISPR-associated protein Cas4. (163 aa)
CUN90569.1Molybdenum cofactor biosynthesis protein A. (296 aa)
CUN90616.1Anaerobic sulfatase-maturating enzyme. (463 aa)
pflA_2Pyruvate formate-lyase-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (103 aa)
hgdC_12-hydroxyglutaryl-CoA dehydratase component A. (1497 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (353 aa)
nifSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (394 aa)
nifUNifU-like protein. (145 aa)
hgdC_22-hydroxyglutaryl-CoA dehydratase component A. (1405 aa)
miaB_1(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (470 aa)
CUO01931.1Coproporphyrinogen III oxidase. (314 aa)
CUO03041.1Uncharacterised protein. (154 aa)
hacAHomoaconitase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (409 aa)
thiH2-iminoacetate synthase. (388 aa)
pyrK_2Dihydrdoorotate oxidase B%2C electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (255 aa)
addBATP-dependent helicase/deoxyribonuclease subunit B; ATP-dependent DNA helicase. (1117 aa)
rpsA30S ribosomal protein S1; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (632 aa)
CUO09454.1Iron hydrogenase 1. (495 aa)
rimORibosomal protein S12 methylthiotransferase RimO; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (448 aa)
pflA_1-2Anaerobic ribonucleotide reductase-activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (178 aa)
CUO13514.1Molybdenum cofactor biosynthesis protein A. (308 aa)
CUO13577.1Iron hydrogenase 1. (481 aa)
sdhB_2L-serine dehydratase%2C beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (222 aa)
sdhA_2L-serine dehydratase%2C alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (289 aa)
bioB_1Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (317 aa)
hcrC4-hydroxybenzoyl-CoA reductase subunit gamma. (157 aa)
hgdC_32-hydroxyglutaryl-CoA dehydratase component A. (552 aa)
mutYA/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (346 aa)
pdgUV-endonuclease; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (210 aa)
CUO26070.1Coproporphyrinogen III oxidase. (289 aa)
rnfCNitrogen fixation protein rnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (438 aa)
rnfBNitrogen fixation protein rnfB; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (283 aa)
CUO37566.1Ferredoxin II. (104 aa)
CUO38330.1NADH oxidase. (665 aa)
miaB_2(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB. (440 aa)
iscSCysteine desulfurase. (380 aa)
CUO39603.1Ferredoxin. (239 aa)
hpdA4-hydroxyphenylacetate decarboxylase activating enzyme. (300 aa)
gltD_3Glutamate synthase [NADPH] small chain. (495 aa)
gltBFerredoxin-dependent glutamate synthase 1. (1512 aa)
queE7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (222 aa)
ydeMAnaerobic sulfatase-maturating enzyme homolog YdeM. (458 aa)
ypfD30S ribosomal protein S1 homolog. (232 aa)
yccMPutative electron transport protein yccM. (282 aa)
ttdAL(+)-tartrate dehydratase subunit alpha. (280 aa)
bioB_2Biotin synthase. (347 aa)
Your Current Organism:
Anaerostipes hadrus
NCBI taxonomy Id: 649756
Other names: A. hadrus, ATCC 29173, Anaerostipes sp. 5/1/63FAA, Clostridiales bacterium SSC/2, DSM 3319, Eubacterium hadrum, JCM 9980, VP 82-52, VPI B2-52, butyrate-producing bacterium SS2/1, butyrate-producing bacterium SSC/2
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