(25 nodes) Homologous recombination network (Edwardsiella ictaluri)

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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protein homology

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	ruvC	Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (173 aa)
	ruvA	Holliday junction branch migration protein RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (202 aa)
	ruvB	Holliday junction branch migration DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (334 aa)
	ARD38292.1	DNA polymerase III subunit theta; Derived by automated computational analysis using gene prediction method: Protein Homology. (75 aa)
	ARD38664.1	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
	ARD39093.1	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
	recO	DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (242 aa)
	dnaQ	DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (243 aa)
	recA	Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa)
	B6E78_08385	Peptide chain release factor 2; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (577 aa)
	ARD39477.1	DNA polymerase III subunit chi; Binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
	ARD39543.1	ssDNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (182 aa)
	priA	Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (731 aa)
	polA	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (930 aa)
	ARD39868.1	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa)
	recF	DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (358 aa)
	recG	ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (693 aa)
	ARD40247.1	DNA polymerase III subunit psi; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. (136 aa)
	recC	Exodeoxyribonuclease V subunit gamma; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and re [...] (1128 aa)
	recB	Exodeoxyribonuclease V subunit beta; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and rep [...] (1197 aa)
	recD	Exodeoxyribonuclease V subunit alpha; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and re [...] (617 aa)
	ARD40486.1	DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1162 aa)
	ARD40665.1	Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
	dnaX	DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (652 aa)
	recR	Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa)

Your Current Organism:

Edwardsiella ictaluri

NCBI taxonomy Id: 67780
Other names: ATCC 33202, CCUG 18764, CIP 81.96, DSM 13697, E. ictaluri, JCM 16934, NCTC 12122, SECFDL GA 77-52

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARD38292.1	ARD38664.1	B6E78_01685	B6E78_04035	DNA polymerase III subunit theta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.948
ARD38292.1	ARD39093.1	B6E78_01685	B6E78_06595	DNA polymerase III subunit theta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.927
ARD38292.1	ARD39477.1	B6E78_01685	B6E78_08920	DNA polymerase III subunit theta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit chi; Binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.930
ARD38292.1	ARD39868.1	B6E78_01685	B6E78_11200	DNA polymerase III subunit theta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.946
ARD38292.1	ARD40247.1	B6E78_01685	B6E78_13470	DNA polymerase III subunit theta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit psi; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.	0.944
ARD38292.1	ARD40486.1	B6E78_01685	B6E78_14850	DNA polymerase III subunit theta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.978
ARD38292.1	dnaQ	B6E78_01685	B6E78_07615	DNA polymerase III subunit theta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.	0.978
ARD38292.1	dnaX	B6E78_01685	B6E78_15905	DNA polymerase III subunit theta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.936
ARD38664.1	ARD38292.1	B6E78_04035	B6E78_01685	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit theta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.948
ARD38664.1	ARD39093.1	B6E78_04035	B6E78_06595	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.987
ARD38664.1	ARD39477.1	B6E78_04035	B6E78_08920	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit chi; Binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.986
ARD38664.1	ARD39868.1	B6E78_04035	B6E78_11200	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.997
ARD38664.1	ARD40247.1	B6E78_04035	B6E78_13470	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit psi; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.	0.987
ARD38664.1	ARD40486.1	B6E78_04035	B6E78_14850	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.988
ARD38664.1	dnaQ	B6E78_04035	B6E78_07615	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.	0.931
ARD38664.1	dnaX	B6E78_04035	B6E78_15905	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.990
ARD38664.1	polA	B6E78_04035	B6E78_10900	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.852
ARD38664.1	recA	B6E78_04035	B6E78_07840	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.678
ARD39093.1	ARD38292.1	B6E78_06595	B6E78_01685	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit theta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.927
ARD39093.1	ARD38664.1	B6E78_06595	B6E78_04035	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.987