(77 nodes) Pyrimidine metabolism network (Aspergillus aculeatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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protein homology

Your Input:
	A0A1L9XA92	Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (212 aa)
	A0A1L9WEH7	Uncharacterized protein. (248 aa)
	A0A1L9WEK2	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (317 aa)
	A0A1L9WEN3	CMP/dCMP-type deaminase domain-containing protein. (348 aa)
	A0A1L9WF16	Uncharacterized protein. (130 aa)
	A0A1L9WF34	Zn(2)-C6 fungal-type domain-containing protein. (714 aa)
	A0A1L9WG76	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (147 aa)
	A0A1L9WH21	Thymidylate_kin domain-containing protein. (221 aa)
	A0A1L9WH35	Nucleoside diphosphate kinase. (153 aa)
	A0A1L9WHK2	Uncharacterized protein. (116 aa)
	A0A1L9WHM1	Zn(2)-C6 fungal-type domain-containing protein. (727 aa)
	A0A1L9WI91	Thymidylat_synt domain-containing protein. (357 aa)
	A0A1L9WIE8	Uncharacterized protein. (143 aa)
	A0A1L9WJ10	Uncharacterized protein. (126 aa)
	A0A1L9WJ36	MFS domain-containing protein. (550 aa)
	A0A1L9WJ42	Uncharacterized protein. (458 aa)
	A0A1L9WJE6	Uncharacterized protein. (229 aa)
	A0A1L9WJG1	Uncharacterized protein. (203 aa)
	A0A1L9WJK1	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (414 aa)
	A0A1L9WK10	Uridine kinase; Belongs to the uridine kinase family. (454 aa)
	A0A1L9WKX6	Glutamine amidotransferase type-1 domain-containing protein. (453 aa)
	A0A1L9WLP9	Importin N-terminal domain-containing protein. (1039 aa)
	A0A1L9WLU0	Uncharacterized protein. (227 aa)
	A0A1L9WM96	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (578 aa)
	A0A1L9WPP2	5_nucleotid_C domain-containing protein; Belongs to the 5'-nucleotidase family. (663 aa)
	A0A1L9WQC2	MFS domain-containing protein. (567 aa)
	A0A1L9WQI4	Fungal_trans domain-containing protein. (655 aa)
	A0A1L9WQU7	Fungal_trans domain-containing protein. (601 aa)
	A0A1L9WR92	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (320 aa)
	A0A1L9WRA5	Uncharacterized protein; Belongs to the iron/ascorbate-dependent oxidoreductase family. (876 aa)
	A0A1L9WRT3	SurE domain-containing protein. (272 aa)
	A0A1L9WS36	Metallophos domain-containing protein. (602 aa)
	A0A1L9WSD8	Uncharacterized protein. (120 aa)
	A0A1L9WSH0	Zn(2)-C6 fungal-type domain-containing protein. (598 aa)
	A0A1L9WSI0	Uncharacterized protein. (119 aa)
	A0A1L9WTR1	Zn(2)-C6 fungal-type domain-containing protein. (641 aa)
	A0A1L9WTS8	Fungal_trans domain-containing protein. (581 aa)
	A0A1L9WUG2	Zn(2)-C6 fungal-type domain-containing protein. (552 aa)
	A0A1L9WUY4	Uncharacterized protein. (782 aa)
	A0A1L9WV55	Uncharacterized protein. (371 aa)
	A0A1L9WVC5	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (506 aa)
	A0A1L9WW83	IU_nuc_hydro domain-containing protein. (421 aa)
	A0A1L9WWF7	Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (394 aa)
	A0A1L9WX25	Nudix hydrolase domain-containing protein. (159 aa)
	A0A1L9WX50	Uncharacterized protein; Belongs to the adenylate kinase family. (116 aa)
	A0A1L9WXM7	HD domain-containing protein. (231 aa)
	A0A1L9WXN3	CMP/dCMP-type deaminase domain-containing protein. (148 aa)
	A0A1L9WYD6	dUTPase domain-containing protein. (149 aa)
	A0A1L9WYJ8	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (714 aa)
	A0A1L9WYX4	Uncharacterized protein. (139 aa)
	A0A1L9WZX5	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
	A0A1L9X0R1	Uncharacterized protein. (401 aa)
	A0A1L9X0W9	OBG-type G domain-containing protein. (412 aa)
	A0A1L9X1W2	Uncharacterized protein. (516 aa)
	A0A1L9X2S8	SurE domain-containing protein. (327 aa)
	A0A1L9X2V9	IU_nuc_hydro domain-containing protein. (374 aa)
	A0A1L9X2W3	Uncharacterized protein. (589 aa)
	A0A1L9X2X4	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (864 aa)
	A0A1L9X314	RED_N domain-containing protein. (590 aa)
	A0A1L9X324	Uncharacterized protein. (450 aa)
	A0A1L9X3I5	TLC domain-containing protein. (406 aa)
	A0A1L9X3P7	MFS domain-containing protein. (587 aa)
	A0A1L9X3V3	F-box domain-containing protein. (732 aa)
	A0A1L9X487	Uncharacterized protein. (78 aa)
	A0A1L9X4A8	Uncharacterized protein. (434 aa)
	A0A1L9X4K7	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (277 aa)
	A0A1L9X4U5	Uncharacterized protein. (127 aa)
	A0A1L9X555	Uncharacterized protein. (137 aa)
	A0A1L9X557	Uncharacterized protein. (190 aa)
	A0A1L9X5R5	Uncharacterized protein. (1172 aa)
	A0A1L9X5T7	dUTPase domain-containing protein. (173 aa)
	A0A1L9X6Q8	Pribosyltran domain-containing protein. (238 aa)
	A0A1L9X7C7	Uncharacterized protein; Belongs to the GroES chaperonin family. (103 aa)
	A0A1L9X7V3	Uncharacterized protein. (450 aa)
	A0A1L9X7Z1	Amidohydro-rel domain-containing protein. (356 aa)
	A0A1L9X8K0	Uncharacterized protein. (2330 aa)
	A0A1L9X9Z9	SurE domain-containing protein. (773 aa)

Your Current Organism:

Aspergillus aculeatus

NCBI taxonomy Id: 690307
Other names: A. aculeatus ATCC 16872, Aspergillus aculeatus ATCC 16872

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1L9WEH7	A0A1L9WEK2	Uncharacterized protein.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.912
A0A1L9WEH7	A0A1L9WEN3	Uncharacterized protein.	CMP/dCMP-type deaminase domain-containing protein.	0.696
A0A1L9WEH7	A0A1L9WG76	Uncharacterized protein.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.749
A0A1L9WEH7	A0A1L9WH21	Uncharacterized protein.	Thymidylate_kin domain-containing protein.	0.501
A0A1L9WEH7	A0A1L9WH35	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.700
A0A1L9WEH7	A0A1L9WI91	Uncharacterized protein.	Thymidylat_synt domain-containing protein.	0.536
A0A1L9WEH7	A0A1L9WJE6	Uncharacterized protein.	Uncharacterized protein.	0.738
A0A1L9WEH7	A0A1L9WJG1	Uncharacterized protein.	Uncharacterized protein.	0.684
A0A1L9WEH7	A0A1L9WLU0	Uncharacterized protein.	Uncharacterized protein.	0.907
A0A1L9WEH7	A0A1L9WM96	Uncharacterized protein.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.426
A0A1L9WEH7	A0A1L9WPP2	Uncharacterized protein.	5_nucleotid_C domain-containing protein; Belongs to the 5'-nucleotidase family.	0.672
A0A1L9WEH7	A0A1L9WQU7	Uncharacterized protein.	Fungal_trans domain-containing protein.	0.481
A0A1L9WEH7	A0A1L9WS36	Uncharacterized protein.	Metallophos domain-containing protein.	0.500
A0A1L9WEH7	A0A1L9WUG2	Uncharacterized protein.	Zn(2)-C6 fungal-type domain-containing protein.	0.501
A0A1L9WEH7	A0A1L9WV55	Uncharacterized protein.	Uncharacterized protein.	0.501
A0A1L9WEH7	A0A1L9WVC5	Uncharacterized protein.	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family.	0.640
A0A1L9WEH7	A0A1L9WW83	Uncharacterized protein.	IU_nuc_hydro domain-containing protein.	0.522
A0A1L9WEH7	A0A1L9WX25	Uncharacterized protein.	Nudix hydrolase domain-containing protein.	0.499
A0A1L9WEH7	A0A1L9WX50	Uncharacterized protein.	Uncharacterized protein; Belongs to the adenylate kinase family.	0.624
A0A1L9WEH7	A0A1L9WXN3	Uncharacterized protein.	CMP/dCMP-type deaminase domain-containing protein.	0.906