STRINGSTRING
purT purT AEG30800.1 AEG30800.1 AEG30831.1 AEG30831.1 purU purU gmk gmk bioD bioD purC purC AEG30883.1 AEG30883.1 AEG30931.1 AEG30931.1 ndk ndk der der rsgA rsgA pyrD pyrD AEG31039.1 AEG31039.1 coaX coaX coaD coaD pyrE pyrE dut dut AEG31069.1 AEG31069.1 AEG31074.1 AEG31074.1 AEG31086.1 AEG31086.1 AEG31087.1 AEG31087.1 AEG31088.1 AEG31088.1 AEG31089.1 AEG31089.1 lgt lgt thyA thyA AEG31092.1 AEG31092.1 AEG31094.1 AEG31094.1 AEG31095.1 AEG31095.1 pyrB pyrB AEG31097.1 AEG31097.1 purD purD purH purH AEG31178.1 AEG31178.1 AEG31203.1 AEG31203.1 ppnP ppnP guaB guaB guaA guaA AEG31274.1 AEG31274.1 purA purA folD folD AEG31318.1 AEG31318.1 dcd dcd purN purN purM purM AEG31398.1 AEG31398.1 purF purF AEG31405.1 AEG31405.1 AEG31435.1 AEG31435.1 AEG31466.1 AEG31466.1 pyrG pyrG AEG31485.1 AEG31485.1 surE surE pcm pcm AEG31488.1 AEG31488.1 pyrF pyrF cmk cmk purL purL AEG31662.1 AEG31662.1 AEG31792.1 AEG31792.1 thiL thiL nusB nusB ribH ribH ribB ribB AEG31806.1 AEG31806.1 AEG31807.1 AEG31807.1 nrdR nrdR glyA glyA AEG31810.1 AEG31810.1 AEG31811.1 AEG31811.1 carB carB carA carA nadK nadK nadE nadE tmk tmk AEG31960.1 AEG31960.1 AEG31961.1 AEG31961.1 panD panD panC panC panB panB AEG32011.1 AEG32011.1 pcnB pcnB purE purE purK purK AEG32127.1 AEG32127.1 nadD nadD AEG32232.1 AEG32232.1 AEG32308.1 AEG32308.1 AEG32324.1 AEG32324.1 bioC bioC AEG32326.1 AEG32326.1 AEG32327.1 AEG32327.1 bioF bioF bioB bioB apt apt
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa)
AEG30800.1Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (196 aa)
AEG30831.1PFAM: Oxidoreductase FAD/NAD(P)-binding; Oxidoreductase FAD-binding region; KEGG: tcx:Tcr_2053 oxidoreductase FAD/NAD(P)-binding. (226 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa)
bioDDethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (241 aa)
purCPFAM: SAICAR synthetase; TIGRFAM: SAICAR synthetase; HAMAP: Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: tcx:Tcr_0262 phosphoribosylaminoimidazole-succinocarboxamide synthase. (295 aa)
AEG30883.1TIGRFAM: Adenosylmethionine--8-amino-7-oxononanoate aminotransferase; KEGG: tcx:Tcr_0277 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa)
AEG30931.1Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (408 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (134 aa)
derGTP-binding protein engA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (475 aa)
rsgARibosome biogenesis GTPase RsgA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (338 aa)
pyrDDihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (315 aa)
AEG31039.1KEGG: tcx:Tcr_1948 biotin--acetyl-CoA-carboxylase ligase; TIGRFAM: Biotin--acetyl-CoA-carboxylase ligase; PFAM: Biotin/lipoate A/B protein ligase. (273 aa)
coaXPutative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (275 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (214 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (153 aa)
AEG31069.1Dihydrofolate reductase; KEGG: tcx:Tcr_1865 short chain dehydrogenase; PFAM: Short-chain dehydrogenase/reductase SDR. (243 aa)
AEG31074.1Allantoinase; KEGG: tcx:Tcr_1889 dihydroorotase; PFAM: Amidohydrolase 3. (443 aa)
AEG31086.1Hypothetical protein; KEGG: tcx:Tcr_1769 HPr kinase. (373 aa)
AEG31087.1PFAM: ATP-grasp fold, RimK-type; KEGG: pin:Ping_2322 RimK domain-containing protein ATP-grasp. (307 aa)
AEG31088.1PFAM: Aminoglycoside phosphotransferase; KEGG: tcx:Tcr_1767 hypothetical protein. (532 aa)
AEG31089.1KEGG: tcx:Tcr_1766 hypothetical protein. (121 aa)
lgtProlipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (271 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa)
AEG31092.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (176 aa)
AEG31094.1KEGG: tcx:Tcr_1831 hypothetical protein. (240 aa)
AEG31095.1KEGG: tcx:Tcr_1830 dihydroorotase, multifunctional complex type; TIGRFAM: Dihydroorotase multifunctional complex type; PFAM: Amidohydrolase 1. (431 aa)
pyrBPFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase; KEGG: tcx:Tcr_1829 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (346 aa)
AEG31097.1KEGG: maq:Maqu_3762 phosphoribosyltransferase; PFAM: Phosphoribosyltransferase. (169 aa)
purDPhosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: tcx:Tcr_0438 phosphoribosylamine--glycine ligase; Belongs to the GARS family. (431 aa)
purHBifunctional purine biosynthesis protein purH; KEGG: tcx:Tcr_0439 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like; TIGRFAM: AICARFT/IMPCHase bienzyme; HAMAP: Bifunctional purine biosynthesis protein purH; SMART: AICARFT/IMPCHase bienzyme, formylation region. (520 aa)
AEG31178.1TIGRFAM: Pseudouridine synthase, RsuA and RluB/E/F; PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; RNA-binding S4; KEGG: bbe:BBR47_08490 pseudouridine synthase; SMART: RNA-binding S4; Belongs to the pseudouridine synthase RsuA family. (230 aa)
AEG31203.1KEGG: tcx:Tcr_1757 HAD family hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase. (227 aa)
ppnPUPF0345 protein yaiE; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (103 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (526 aa)
AEG31274.1KEGG: abo:ABO_1802 CinA domain-containing protein; TIGRFAM: CinA, C-terminal; PFAM: CinA, C-terminal; Belongs to the CinA family. (168 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (438 aa)
folDBifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa)
AEG31318.1PFAM: NAD-dependent histone deacetylase, silent information regulator Sir2; KEGG: hhe:HH0572 hypothetical protein. (261 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (204 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (225 aa)
purMTIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; Bacteriocin-type signal sequence motif; KEGG: tcx:Tcr_1046 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein. (346 aa)
AEG31398.1FolC bifunctional protein; TIGRFAM: Folylpolyglutamate synthetase; KEGG: tcx:Tcr_0806 FolC bifunctional protein; PFAM: Mur ligase, central; Mur ligase, C-terminal; Belongs to the folylpolyglutamate synthase family. (441 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (507 aa)
AEG31405.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (281 aa)
AEG31435.1TIGRFAM: Adenylosuccinate lyase; KEGG: tcx:Tcr_1137 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (473 aa)
AEG31466.1TIGRFAM: Nicotinate-nucleotide pyrophosphorylase; KEGG: asa:ASA_0415 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (283 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (543 aa)
AEG31485.1KEGG: tcx:Tcr_1258 Smr protein/MutS2-like; PFAM: Smr protein/MutS2 C-terminal; SMART: Smr protein/MutS2 C-terminal. (189 aa)
surEMultifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (248 aa)
pcmProtein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (237 aa)
AEG31488.1PFAM: SNARE associated Golgi protein; KEGG: tcx:Tcr_1255 hypothetical protein. (192 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (239 aa)
cmkPFAM: Cytidylate kinase region; TIGRFAM: Cytidylate kinase; HAMAP: Cytidylate kinase; KEGG: tcx:Tcr_1197 cytidylate kinase. (219 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1290 aa)
AEG31662.1L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (521 aa)
AEG31792.1Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (365 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (327 aa)
nusBNusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (167 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (153 aa)
ribB3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (371 aa)
AEG31806.1Riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; KEGG: tcx:Tcr_1399 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein. (215 aa)
AEG31807.1Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (386 aa)
nrdRTranscriptional repressor nrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (155 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
AEG31810.1TIGRFAM: ATP-binding cassette protein, ChvD family; PFAM: ABC transporter-like; KEGG: tcx:Tcr_1403 putative ABC transporter ATP-binding protein; SMART: ATPase, AAA+ type, core. (555 aa)
AEG31811.1TIGRFAM: Diguanylate cyclase, predicted; PFAM: Diguanylate cyclase, predicted; PAS fold-4; KEGG: tcx:Tcr_1404 diguanylate cyclase; SMART: Diguanylate cyclase, predicted. (305 aa)
carBTIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: tcx:Tcr_0879 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Belongs to the CarB family. (1071 aa)
carATIGRFAM: Carbamoyl phosphate synthase, small subunit; KEGG: tcx:Tcr_0878 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (380 aa)
nadKInorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (291 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (549 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa)
AEG31960.1Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (758 aa)
AEG31961.1PFAM: Ribonucleotide reductase; KEGG: tcx:Tcr_1763 ribonucleotide-diphosphate reductase subunit beta. (377 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (128 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (290 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (263 aa)
AEG32011.1TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: tcx:Tcr_1527 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (182 aa)
pcnBpoly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (469 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (166 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (371 aa)
AEG32127.1Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (126 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (232 aa)
AEG32232.1PFAM: Conserved hypothetical protein CHP00730; KEGG: tcx:Tcr_1882 hypothetical protein. (459 aa)
AEG32308.1Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (238 aa)
AEG32324.1PFAM: Invasion gene expression up-regulator, SirB; KEGG: pol:Bpro_4728 invasion gene expression up-regulator, SirB. (123 aa)
bioCBiotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (310 aa)
AEG32326.1Carboxylesterase; KEGG: tcx:Tcr_1980 alpha/beta hydrolase fold; PFAM: Alpha/beta hydrolase fold-1. (264 aa)
AEG32327.1KEGG: tcx:Tcr_1862 cold-shock DNA-binding domain-containing protein; PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein. (69 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (385 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (350 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (175 aa)
Your Current Organism:
Thiomicrospira cyclica
NCBI taxonomy Id: 717773
Other names: T. cyclica ALM1, Thioalkalimicrobium cyclicum ALM1, Thiomicrospira cyclica ALM1
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.