STRINGSTRING
Arfip Arfip ATP7 ATP7 Lerp Lerp CG10365 CG10365 Fur1 Fur1 PICK1 PICK1 Afti Afti Csas Csas lqfR lqfR Chc Chc Pi4KIIalpha Pi4KIIalpha Rab32 Rab32 AP-1gamma AP-1gamma Gga Gga Scamp Scamp Fur2 Fur2 AP-1-2beta AP-1-2beta Gorab Gorab Golgin104 Golgin104 Arl1 Arl1 Tsp68C Tsp68C Arl5 Arl5 TBC1D23 TBC1D23 Vps52 Vps52 Rab30 Rab30 Sec71 Sec71 Rab9 Rab9 CG31475 CG31475 Trs33 Trs33
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ArfipArfaptin (Arfip) a protein that functions to tether the dynactin complex to the Golgi membrane in motor neurons. This function is required for normal synaptic growth during larval development. (355 aa)
ATP7ATP7, isoform B; ATP7 (ATP7) encodes a copper transmembrane transporter involved in cuticle pigmentation, copper homeostasis and larval development. (1254 aa)
LerpLysosomal enzyme receptor protein (Lerp) encodes a protein involved in lysosome function and autophagy. (918 aa)
CG10365Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (284 aa)
Fur1Furin-like protease 1, isoforms 1/1-X/2; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. (1478 aa)
PICK1Membrane curvature sensor activity; phospholipid binding; protein kinase C binding; protein domain specific binding. (577 aa)
AftiAftiphilin, isoform E; Aftiphilin (Afti) encodes an AP-1 adaptor complex binding protein involved in eye photoreceptor development and intracellular transport. (1161 aa)
CsasCMP-sialic acid synthase; N-acylneuraminate cytidylyltransferase activity. It is involved in the biological process described with: response to heat; chemical synaptic transmission. (248 aa)
lqfRLiquid facets-Related (lqfR) encodes a Golgi protein involved in cell proliferation and oogenesis. (1415 aa)
ChcClathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. (1678 aa)
Pi4KIIalphaPi4KIIalpha, isoform A; Pi4KIIalpha (Pi4KIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It contributes to membrane trafficking in the larval salivary gland. (710 aa)
Rab32Rab32, isoform B; Rab32 (Rab32) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in eye development, autophagy and lipid storage. (686 aa)
AP-1gammaAdaptor Protein complex 1, gamma subunit (AP-1gamma) encodes a clathrin adaptor involved in vesicle trafficking. (982 aa)
GgaGolgi-localized, gamma-adaptin ear containing, ARF binding protein (Gga) encodes a clathrin binding protein involved in post-Golgi vesicle-mediated transport. (660 aa)
ScampSecretory carrier-associated membrane protein; It is involved in the biological process described with: neuromuscular synaptic transmission; synaptic vesicle exocytosis; protein transport; long-term memory. (343 aa)
Fur2Furin-like protease 2; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. (1682 aa)
AP-1-2betaAdaptor Protein complex 1/2, beta subunit (AP-1-2beta) encodes a clathrin adaptor involved in vesicle trafficking and autophagy regulation. (921 aa)
GorabRAB6-interacting golgin; Required for centriole duplication probably through the interaction with Sas-6. During embryogenesis, maternally provided Gorab is required for centrosome duplication and nuclear division cycles of the syncytial embryos. In femoral chordotonal organs, required for sensory cilia structural integrity and functionality necessary for motor coordination. In male germline, has a role in cytokinesis which seems dependent on its localization to the Golgi. (338 aa)
Golgin104Golgin 104; Rab GTPase binding. (776 aa)
Arl1ADP-ribosylation factor-like protein 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. (180 aa)
Tsp68CTetraspanin 68C (Tsp68C) encodes a member of the tetraspanin superfamily of integral membrane proteins that are involved in cell adhesion and signal transduction. Its proposed functions include the regulation of Notch signaling and the control of Ras/Raf-mediated proliferation in hemocytes; Belongs to the tetraspanin (TM4SF) family. (362 aa)
Arl5ADP-ribosylation factor-like 5 (Arl5) encodes a protein involved in endosome-to-Golgi trafficking; Belongs to the small GTPase superfamily. Arf family. (179 aa)
TBC1D23Uncharacterized protein; GTPase activator activity. It is involved in the biological process described with: positive regulation of intracellular transport; retrograde transport, endosome to Golgi; regulation of GTPase activity. (689 aa)
Vps52Vacuolar protein sorting 52; Rab GTPase binding; syntaxin binding. It is involved in the biological process described with: retrograde transport, endosome to Golgi; lysosomal transport; Golgi to vacuole transport; endocytic recycling. (662 aa)
Rab30Rab30, isoform A; Rab30 (Rab30) encodes a JNK transcriptional target. It is involved in JNK-mediated processes such as dorsal closure, embryonic head involution and thorax closure. (223 aa)
Sec71Secretory 71; Small GTPase binding; ARF guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: positive regulation of neuron remodeling; positive regulation of endocytosis; Golgi to plasma membrane protein transport; regulation of ARF protein signal transduction. (1653 aa)
Rab9RE17845p; Rab9 (Rab9) encodes a member of the Rab subfamily of small GTPases associated with late endosomes. It promotes membrane budding and retrograde recycling of endocytosed materials to the Golgi apparatus. Its roles include recycling of tracheal luminal proteins and tracheal tube length control. (256 aa)
CG31475GH10101p; Calcium ion binding. It is involved in the biological process described with: calcium-ion regulated exocytosis. (418 aa)
Trs33TRAPP subunit 33; It is involved in the biological process described with: regulation of GTPase activity; vesicle-mediated transport; Golgi vesicle transport; endoplasmic reticulum to Golgi vesicle-mediated transport. (152 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.