STRINGSTRING
Trs20 Trs20 Trs23 Trs23 Bet5 Bet5 Vamp7 Vamp7 cm cm Sec22 Sec22 AP-1sigma AP-1sigma CG9067 CG9067 AP-1mu AP-1mu AP-2sigma AP-2sigma AP-2mu AP-2mu or or Ykt6 Ykt6 deltaCOP deltaCOP SrpRalpha SrpRalpha zetaCOP zetaCOP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Trs20Probable trafficking protein particle complex subunit 2; May play a role in vesicular transport from endoplasmic reticulum to Golgi. Involved in dsRNA uptake. (139 aa)
Trs23Trafficking protein particle complex subunit; Rab guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport; vesicle-mediated transport; Golgi vesicle transport; Belongs to the TRAPP small subunits family. (219 aa)
Bet5Trafficking protein particle complex subunit; Rab guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: Golgi vesicle transport; vesicle-mediated transport; endoplasmic reticulum to Golgi vesicle-mediated transport; Belongs to the TRAPP small subunits family. (145 aa)
Vamp7Vesicle-associated membrane protein 7 (Vamp7) encodes an R type SNARE protein. It mediates the fusion of autophagosomes with endosomes and lysosomes by forming a SNARE complex with the products of Syx17 and Snap29. It localizes to endosomes in a Rab21 and Sbf dependent manner; Belongs to the synaptobrevin family. (218 aa)
cmMu3 subunit of clathrin-associated protein complex AP-3; Cargo adaptor activity; Belongs to the adaptor complexes medium subunit family. (415 aa)
Sec22Secretory 22, isoform B; Secretory 22 (Sec22) encodes a protein involved in Wnt protein secretion; Belongs to the synaptobrevin family. (213 aa)
AP-1sigmaAP complex subunit sigma; Clathrin adaptor activity; clathrin binding; Belongs to the adaptor complexes small subunit family. (157 aa)
CG9067Uncharacterized protein; It is involved in the biological process described with: Golgi vesicle transport; endoplasmic reticulum to Golgi vesicle-mediated transport. (138 aa)
AP-1muAdaptor Protein complex 1, mu subunit (AP-1mu) encodes a clathrin adaptor involved in intracellular transport. It controls the trafficking of proteins, including the products of N and spdo. (426 aa)
AP-2sigmaAdaptor Protein complex 2, sigma subunit (AP-2sigma) encodes a component of the AP-2 adaptor complex, which recruits certain transmembrane proteins into clathrin-coated pits for endocytic internalization. (142 aa)
AP-2muAdaptor Protein complex 2, mu subunit (AP-2mu) encodes a component of the AP-2 adaptor complex, which recruits certain transmembrane proteins into clathrin-coated pits for endocytic internalization. (437 aa)
orAdaptor protein complex AP-3 small chain sigma3; Orange (or) encodes an AP-3 adaptor complex component involved in ommochrome biosynthesis. (191 aa)
Ykt6YKT6 v-SNARE; Protein-cysteine S-palmitoyltransferase activity; SNAP receptor activity. It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; vesicle-mediated transport; Belongs to the synaptobrevin family. (199 aa)
deltaCOPCoatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (532 aa)
SrpRalphaSignal recognition particle receptor subunit alpha homolog; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May have a role in axonogenesis. (614 aa)
zetaCOPCoatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (174 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.