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| | Apc | APC-like, isoform A; APC-like (Apc) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary family member during CNS and eye development, and functions redundantly with the product of Apc2 in adult development. (2417 aa) |
| | rb | Ruby (rb) encodes the beta3-adaptin subunit of the Adaptor protein-3 (AP-3) complex involved in biogenesis of lysosome-related organelles. It is required for regulation of lipid storage, eye pigment biogenesis and the processing of the receptor encoded by N. (1160 aa) |
| | CG1575 | LD45266p. (637 aa) |
| | IntS4 | Integrator complex subunit 4; Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. Essential for development. May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (1022 aa) |
| | AP-1gamma | Adaptor Protein complex 1, gamma subunit (AP-1gamma) encodes a clathrin adaptor involved in vesicle trafficking. (982 aa) |
| | insc | Inscuteable (insc) encodes an adaptor protein required for asymmetric cell division. It interacts with the microtubule binding protein encoded by mud and the adaptor encoded by pins. It also binds to the apical complex proteins encoded by baz, par-6 and aPKC and may recruit microtubule binding proteins to the apical cell cortex to induce apical-basal spindle orientation. (859 aa) |
| | CG4554 | DRIM domain-containing protein. (2733 aa) |
| | CG12084 | Protein zer-1 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. (793 aa) |
| | CG32668 | Uncharacterized protein. (863 aa) |
| | g | AP-3 complex subunit delta; Garnet (g) encodes a protein that forms the Adaptor protein 3 (AP-3) complex together with the other subunits encoded by or, rb and cm. These complexes select cargo for inclusion into vesicles for transport within the cell. AP-3 delivers protein cargo to a number of specialized organelles including pigment granules, late endosomes, lysosomes and synaptic vesicles. AP-3 genes were first found through defects in pigment granules that alter eye color. (1034 aa) |
| | shtd | Shattered (shtd) encodes the largest subunit that forms the scaffold of the Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligase. APC/C is active during mitosis and G1 phases of the cell cycle to mediates the degradation of cyclins and other key cell cycle regulators, which triggers the metaphase to anaphase transition and the exit from mitosis. (2030 aa) |
| | mei-41 | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination. Phosphorylates grp/CHK1. Phosphorylates 'Ser-137' of histone variant H2AX/H2AV at sites of DNA damage, thereby regulating DNA damage response mechanism. [...] (2517 aa) |
| | betaCOP | Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. (964 aa) |
| | Rcd-1 | Required for cell differentiation 1, isoform A; It is involved in the biological process described with: negative regulation of translation; mRNA catabolic process. (304 aa) |
| | AP-1-2beta | Adaptor Protein complex 1/2, beta subunit (AP-1-2beta) encodes a clathrin adaptor involved in vesicle trafficking and autophagy regulation. (921 aa) |
| | gig | Gigas, isoform A; Gigas (gig) encodes a tumour suppressor protein that, together with with the product of Tsc1, controls cellular growth via antagonizing insulin and TOR signalling pathways. (1847 aa) |
| | Kap-alpha1 | Importin subunit alpha; Karyopherin alpha1 (Kap-alpha1) encodes a protein that is involved in spermatogenesis and the nuclear import of the product of yki. (543 aa) |
| | Rpn1 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (919 aa) |
| | Ltn1 | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to TER94/VCP recruitment for extraction and degradation of the incomplete translation product (By similarity). Belongs to the LTN1 family. (1747 aa) |
| | Apl | Apollo, isoform A; Ran GTPase binding; nuclear localization sequence binding; nuclear import signal receptor activity. It is involved in the biological process described with: protein import into nucleus. (1080 aa) |
| | Mo25 | Mo25 (Mo25) encodes a protein involved in neuroblast asymmetric cell divisions via localization of the product of mira. It physically interacts with the kinase encoded by Lkb1; Belongs to the Mo25 family. (339 aa) |
| | Frl | Formin-like protein; Together with Cdc42, involved in establishment of planar cell polarity in the developing compound eye by contributing to ommatidial rotation. Together with DAAM and Cdc42, has a role in neuronal development of mushroom bodies. (1183 aa) |
| | msk | D-Importin 7/RanBP7; Moleskin (msk) encodes an importin that contributes to protein import into the nucleus. It is involved in eye development, muscle attachment and wing cell fate specification. (1049 aa) |
| | Tnpo | Transportin, isoform A; Transportin (Tnpo) encodes a protein involved in Hh signalling regulation by mediating the import of the transcription factor encoded by ci into the nucleus. (893 aa) |
| | CG8219 | Importin N-terminal domain-containing protein; Ran GTPase binding; nuclear localization sequence binding; nuclear import signal receptor activity. It is involved in the biological process described with: protein import into nucleus. (853 aa) |
| | alphaKap4 | Importin subunit alpha; Nuclear import signal receptor activity; nuclear localization sequence binding. It is involved in the biological process described with: proteasome assembly; NLS-bearing protein import into nucleus; Belongs to the importin alpha family. (442 aa) |
| | peng | Protein penguin; mRNA binding. It is involved in the biological process described with: regulation of translation; apposition of dorsal and ventral imaginal disc-derived wing surfaces. (737 aa) |
| | TBCD | Tubulin folding cofactor D (TBCD) encodes one of the tubulin folding cofactors, which assist in the formation of tubulin heterodimers. It cooperates with the product of Dscam1 to regulate microtubule organization during neural development. (1189 aa) |
| | Sym | Symplekin (Sym) encodes a large protein that contains many protein interaction sites, and acts as a scaffold for protein complexes in the nucleus. It functions in RNA 3' end formation for both polyadenyated mRNAs and non-polyadenylated histone mRNAs. In some cells it also localizes to the cell cortex, especially the tricellular junctions of some epithelia. (1165 aa) |
| | Mms19 | GH06271p; It is involved in the biological process described with: iron-sulfur cluster assembly; protein maturation by iron-sulfur cluster transfer. (959 aa) |
| | Karybeta3 | Karyopherin beta 3, isoform A; Nuclear localization sequence binding; nuclear import signal receptor activity. It is involved in the biological process described with: protein import into nucleus. (1105 aa) |
| | l(2)k09022 | HEAT repeat-containing protein 1 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity); Belongs to the HEATR1/UTP10 family. (2096 aa) |
| | gudu | Armadillo repeat-containing protein gudu; Important for spermatogenesis where it may have a role in sperm individualization. (669 aa) |
| | emb | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm. Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae. Required for the function or maintenance of certain tissues such as brain and gut. (1063 aa) |
| | Rcd-1r | Rcd-1 related; It is involved in the biological process described with: negative regulation of translation; spermatogenesis; mRNA catabolic process; reproductive process. (290 aa) |
| | Pen | Importin subunit alpha; Pendulin (Pen) encodes a member of the Importin-alpha protein family, an essential adaptor in the Ran-GTP nuclear transport cycle binding a cargo protein to the nuclear import receptor encoded by Fs(2)Ket. In addition to nuclear protein import, the product of Pen is involved in centrosome duplication, mitotic spindle dynamics, nuclear envelope assembly, ring canal formation in the female germline, geotaxic behaviour and perception of pain. (522 aa) |
| | Ufd4 | E3 ubiquitin-protein ligase Ufd4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Kcmf1 to mediate the ubiquitination and proteasomal degradation of rl/MAPK. (2727 aa) |
| | Ced-12 | Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. (724 aa) |
| | Sec71 | Secretory 71; Small GTPase binding; ARF guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: positive regulation of neuron remodeling; positive regulation of endocytosis; Golgi to plasma membrane protein transport; regulation of ARF protein signal transduction. (1653 aa) |
| | Cse1 | Exportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). (975 aa) |
| | VhaSFD | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). (542 aa) |
| | cass | Apoptosis inhibitor 5 homolog; Antiapoptotic factor. Also known to efficiently suppress E2F1-induced apoptosis. (536 aa) |
| | CG10137 | GH24474p. (941 aa) |
| | CG10286 | GH12023p; Unfolded protein binding. It is involved in the biological process described with: ribosomal large subunit biogenesis; protein import into nucleus. (625 aa) |
| | Neurochondrin | Neurochondrin homolog; Strongly up-regulated in Mhc mutants suggesting a role in muscle function; Belongs to the neurochondrin family. (723 aa) |
| | Vps15 | Vacuolar protein sorting 15 (Vps15) encodes a serine/threonine protein kinase that is a core component of the Vps34/class III PI3-Kinase complex. It is required for the production of PI3P and influences multiple vesicle trafficking pathways, including autophagy and endocytosis. (1342 aa) |
| | CG11964 | LD41978p. (581 aa) |
| | Kap-alpha3 | Importin subunit alpha; Karyopherin alpha3 (Kap-alpha3) encodes a protein required for the nuclear import of the product of N; Belongs to the importin alpha family. (514 aa) |
| | Ranbp9 | Ran GTPase binding. It is involved in the biological process described with: protein import into nucleus. (1018 aa) |
| | CG5608 | FI07645p; It is involved in the biological process described with: phosphatidylinositol biosynthetic process; positive regulation of kinase activity. (687 aa) |
| | HEATR2 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. (845 aa) |
| | CG14881 | Uncharacterized protein, isoform A. (286 aa) |
| | wrd | Well-rounded, isoform B; Well-rounded (wrd) encodes one of the two regulatory B' subunits of the protein phosphatase PP2A. It influences metabolism and growth via negative regulation of the InR/TOR signalling network. (984 aa) |
| | CG7044 | FI02071p; It is involved in the biological process described with: cellular response to DNA damage stimulus; cell population proliferation. (974 aa) |
| | Sil1 | Nucleotide exchange factor Sil1; Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for an ER lumenal chaperone of HSP70 family (By similarity). Belongs to the SIL1 family. (429 aa) |
| | CG6073 | Protein HGH1 homolog; Belongs to the HGH1 family. (369 aa) |
| | wdb | Widerborst (wdb) encodes a B' regulatory subunit of the serine/threonine phosphatase complex PP2A. It regulates Hedgehog, protein kinase B and insulin receptor signaling pathways. (524 aa) |
| | CG1951 | LD39455p; ATP binding. It is involved in the biological process described with: protein phosphorylation; multicellular organism reproduction. (835 aa) |
| | Cap-D2 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1380 aa) |
| | Rnb | LD33331p; It is involved in the biological process described with: regulation of circadian rhythm. (975 aa) |
| | nero | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor (By similarity). Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A-mediated translational control; Belongs to the deoxyhypusine hydroxylase family. (302 aa) |
| | vimar | Visceral mesodermal armadillo-repeats (vimar) encodes a protein involved in regulation of muscle homeostasis and rhabdomere development. Its expression in the visceral mesoderm is controlled by the product of bap. (635 aa) |
| | CG5721 | Armadillo repeat-containing protein 6 homolog; It is involved in the biological process described with: hematopoietic progenitor cell differentiation; Belongs to the ARMC6 family. (464 aa) |
| | CG10950 | Xpo1 domain-containing protein. (586 aa) |
| | Impbeta11 | Ran GTPase binding. It is involved in the biological process described with: protein import into nucleus. (1075 aa) |
| | CG13326 | GH11924p. (867 aa) |
| | CG8858 | Proteasome-associated protein ECM29 homolog; It is involved in the biological process described with: proteasome assembly. (1890 aa) |
| | Rme-8 | Receptor mediated endocytosis 8 (Rme-8) encodes a protein involved in the regulation of border follicle cell migration and the endocytosis of the receptor encoded by N. (2408 aa) |
| | CG11123 | RH42110p; RNA binding. (665 aa) |
| | chb | CLIP-associating protein; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for several aspects of mitotic spindle formation including the formation of the overlapping central spindle microtubules and kinetochore attachment. Required for the incorporation of tubulin subunits at the plus ends of kinetochore microtubules during poleward microtubule flux. Acts antagonistically to Klp10A and Klp67A to maintain metaphase spindle length. Also required for guidance of CNS axons downstream of Abl. May function to identify a subset of microt [...] (1491 aa) |
| | AP-2alpha | AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP- 2alpha is a subunit of the plasma membrane adapter. (952 aa) |
| | arm | Armadillo segment polarity protein; Isoform neural may associate with CadN and participate in the transmission of developmental information. Can associate with alpha- catenin. Isoform cytoplasmic accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis. Belongs to the beta-catenin family. (843 aa) |
| | CG10973 | LD28549p; Adenyl-nucleotide exchange factor activity. (306 aa) |
| | stmA | Protein EFR3 homolog cmp44E; An essential gene required for embryogenesis; required for cell viability; Belongs to the EFR3 family. (834 aa) |
| | p120ctn | Adherens junction protein p120 (p120ctn) encodes an important modulator of cell adhesion. It binds to and stabilizes classic cadherin cell adhesion receptors at the cell surface. Unlike its mammalian homologs, it is non-essential but becomes essential if the levels of the product of shg are reduced. (781 aa) |
| | form3 | Formin 3, isoform B; Formin 3 (form3) encodes a protein that belongs to the formin family, which functions in various actin-based processes. It is involved in tracheal fusion. (1717 aa) |
| | l(3)80Fj | Uncharacterized protein, isoform A; Protein kinase binding; ribosome binding; protein kinase regulator activity. It is involved in the biological process described with: positive regulation of kinase activity; regulation of translation. (2630 aa) |
| | Kap3 | Kinesin associated protein 3 (Kap3) encodes the non-motor accessory subunit of the heterotrimeric kinesin-2. It associates to the coiled-coil stalk domain of the products of Klp68D andKlp64D. It plays an essential role in sensory cilia assembly and axonal transport. (1038 aa) |
| | Cap-G | Chromosome associated protein G (Cap-G) encodes a component of the condensin I complex, necessary for accurate mitotic and meiotic chromosome segregation. (1351 aa) |
| | ctrip | Circadian trip (ctrip) encodes a HECT ubiquitin ligase that regulates the levels and circadian oscillations of the transcriptional activator encoded by Clk. It plays a role in the control of rest-activity rhythms. (3140 aa) |
| | Hel89B | Helicase 89B (Hel89B) encodes a protein that belongs to the SNF2 family of chromatin regulators. Hel89B product binds to large number of sites on polytene chromosomes and positively regulates the expression of antimicrobial peptide genes. (1923 aa) |
| | CG42399 | Uncharacterized protein, isoform B; Microtubule binding. It is involved in the biological process described with: microtubule cytoskeleton organization. (1655 aa) |
| | DAAM | Dishevelled Associated Activator of Morphogenesis (DAAM) encodes a formin type of actin assembly factor regulated by Rho GTPases. It plays a role in tracheal tube length regulation, tracheal cuticle pattern formation, growth cone filopodia formation, sarcomerogenesis and axonal growth regulation in embryonic and mushroom body neurons. (1463 aa) |
| | Nipped-A | Transcription-associated protein 1; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double- strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. During wing development, required for activity of Notch and its coactivator mam. Function in promoting mam function is likely to involve both the Tip60 and SAGA complexes. (3790 aa) |
| | Ranbp16 | Ran-binding protein 16; May function as a nuclear transport receptor. (1110 aa) |
| | msps | Protein mini spindles; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. May act as a microtubule antipause factor that rapidly catalyzes the transition from pause to either growth or shrinkage. Involved in mitotic spindle elongation. Involved in the establishment of cell polarity and mitotic spindle orientation in neuroblasts. Required for maintaining the bipolarity of acentrosomal meiotic spindles; the function is dependent on tacc and involves ncd. Involved in oocyte micr [...] (2082 aa) |
| | Sarm | NAD(+) hydrolase sarm1; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, it is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) c [...] (1730 aa) |
| | Fs(2)Ket | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. (884 aa) |
| | dia | Protein diaphanous; Required for cytokinesis in both mitosis and meiosis. Has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination. May serve as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle. Possible component of the contractile ring or may control its function. (1098 aa) |
| | pds5 | Precocious dissociation of sisters 5 (pds5) encodes a protein that interacts with the product of wapl to form the releasin complex, which enables sister chromatid separation at mitosis by removing the cohesin ring complex from chromosomes. The product of pds5 influences gene activation and silencing through interactions with cohesin. It is also required to initiate and/or maintain sister chromatid cohesion. (1218 aa) |
| | gammaCOP | Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required [...] (897 aa) |
| | Rpn2 | 26S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (1029 aa) |
| | Arts | Artemis, isoform B; Nuclear localization sequence binding; Ran GTPase binding; nuclear import signal receptor activity. It is involved in the biological process described with: protein import into nucleus. (1080 aa) |
| | CG1344 | Uncharacterized protein, isoform A. (683 aa) |
| | Cand1 | Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (Probable); Belongs to the CAND family. (1248 aa) |
| | Sf3b1 | Splicing factor 3b subunit 1, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: spliceosomal complex assembly; mRNA splicing, via spliceosome. (1340 aa) |
| | pum | Maternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...] (1533 aa) |
| | yata | Yata, isoform A; ATP binding. It is involved in the biological process described with: protein phosphorylation. (873 aa) |
| | Fhos | Formin homology 2 domain containing (Fhos) encodes a protein that regulates actin-dependent remodeling of muscle cytoskeleton via induction of actin stress fibers, directs macrophage migration during cellular immune response, and is involved in autophagic programmed cell death. (2528 aa) |
| | Tnpo-SR | Transportin-Serine/Arginine rich (Tnpo-SR) encodes a importin-beta family protein involved in the regulation of mRNA splicing. It contributes to the import into the nucleus of serine/arginine-rich (SR) proteins, which are involved in mRNA splicing. (932 aa) |
| | CG15443 | RH51096p. (358 aa) |
| | CG2747 | Uncharacterized protein, isoform F; It is involved in the biological process described with: protein localization; endocytosis; retrograde transport, endosome to Golgi. (2172 aa) |
| | cdm | Cadmus, isoform A; Cadmus (cdm) encodes a member of the importin beta family of nucleocytoplasmic cargo shuttling proteins. It functions at the neuromuscular junction to maintain normal subsynaptic reticulum structure and presynaptic probability of release. (971 aa) |
| | Tor | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] (2471 aa) |
| | mwh | Multiple wing hairs (mwh) encodes the most downstream member of the fz/stan planar cell polarity pathway. It binds to the sides of F-actin polymers, inhibits actin polymerization and bundles F-actin. It accumulates on the proximal side of wing cells prior to hair initiation and then in the growing hair. (1069 aa) |
| | ebo | Ellipsoid body open (ebo) encodes a protein that complexes with actin, the product of chic, and Ran-GTPase to mediate actin nuclear export. Loss of ebo during development results in defects in the ellipsoid body of the central complex. In the adult brain, accumulation of nuclear actin results in the inhibition of the product of bs and subsequent loss of visual orientation memory. (1054 aa) |
| | Pp2A-29B | Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit; Protein phosphatase 2A at 29B (Pp2A-29B) encodes the structural A subunit of the trimeric PP2A phosphatase enzyme. It links the catalytic C subunit encoded by mts and a variable regulatory B family subunit, which directs the enzyme to distinct substrates. The roles of Pp2A-29B product include centriole duplication, chromosome segregation, autophagy, axonal transport, growth regulation, and active zone stabilization. (650 aa) |
| | p115 | General vesicular transport factor p115; Essential for maintaining the architecture of the Golgi stacks and for normal organization of the transitional endoplasmic reticulum (tER). Required for both the formation of the Golgi stacks and the maintenance of the individual cisternae. Belongs to the VDP/USO1/EDE1 family. (836 aa) |
| | CG2691 | RRP12-like protein; It is involved in the biological process described with: rRNA processing. (1384 aa) |
| | CG4975 | Uncharacterized protein, isoform C. (418 aa) |
| | Ranbp21 | Ranbp21, isoform A; RNA binding; nuclear export signal receptor activity; Ran GTPase binding. It is involved in the biological process described with: regulation of protein export from nucleus; RNA export from nucleus. (1241 aa) |
| | CG10383 | LD21810p; CG10383 encodes a hydrolase involved in the regulation of glycosylphosphatidylinositol metabolism, determination of lifespan and sleep. (784 aa) |
| | CG16989 | SD22791p. (940 aa) |
| | CG32568 | Uncharacterized protein, isoform B; Protein phosphatase activator activity. It is involved in the biological process described with: regulation of protein autophosphorylation; signal transduction; protein dephosphorylation. (325 aa) |
| | c11.1 | C11.1, isoform A. (1742 aa) |
| | CG2053 | IP11148p; It is involved in the biological process described with: negative regulation of translation; mRNA catabolic process. (298 aa) |
| | Plap | Phospholipase A2 activator protein, isoform A; Ubiquitin binding. It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin recycling. (787 aa) |
| | wapl | Wings apart-like (wapl) encodes a protein that interacts with the product of pds5 to form the releasin complex that enables sister chromatid separation at mitosis by removing the cohesin ring complex from chromosomes. It also influences gene activation and silencing through interactions with cohesin. (1741 aa) |
| | raptor | Raptor, isoform B; Raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism. (1621 aa) |
| | ric8a | Synembryn; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i) alpha protein independently of G-protein coupled receptors. In addition to its GEF activity, it plays an essential role in cortical subcellular localization of heterotrimeric G proteins, suggesting it acts as a facilitator of G-alpha funct [...] (573 aa) |
| | unc-45 | Uncoordinated 45 (unc-45) encodes a protein that binds the product of Hsp83 and myosin, and may may serve as a scaffold for their interaction. It is required for normal myosin accumulation and appears to play a role in myosin folding and/or protection from stress. (947 aa) |
| | CG6972 | Uncharacterized protein, isoform B; It is involved in the biological process described with: muscle system process; protein modification by small protein removal. (296 aa) |
| | Apc2 | Adenomatous polyposis coli 2 (Apc2) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary APC family member during embryonic development, and functions redundantly with the product of Apc in adult development. (1067 aa) |
