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boss boss AstA-R2 AstA-R2 AdoR AdoR Sap-r Sap-r AstC-R1 AstC-R1 AkhR AkhR fz3 fz3 CCKLR-17D3 CCKLR-17D3 CCKLR-17D1 CCKLR-17D1 moody moody CCAP-R CCAP-R GABA-B-R1 GABA-B-R1 smog smog PK1-R PK1-R NPFR NPFR Pdfr Pdfr Dro Dro Octalpha2R Octalpha2R CrzR CrzR fz fz Octbeta2R Octbeta2R MsR1 MsR1 rk rk Oamb Oamb Octbeta1R Octbeta1R CG31760 CG31760 mthl11 mthl11 sNPF-R sNPF-R Calr Calr ETHR ETHR CG12290 CG12290 SPR SPR CG4313 CG4313 Lgr4 Lgr4 Dop2R Dop2R GABA-B-R3 GABA-B-R3 TyrRII TyrRII CG7497 CG7497 TyrR TyrR AstC-R2 AstC-R2 MsR2 MsR2 Proc Proc CG13995 CG13995 CapaR CapaR Lkr Lkr CNMaR CNMaR Rh7 Rh7 hec hec Akh Akh mthl10 mthl10 mth mth CG13575 CG13575 mAChR-C mAChR-C Proc-R Proc-R AstA-R1 AstA-R1 mAChR-B mAChR-B PK2-R1 PK2-R1 PK2-R2 PK2-R2 Lgr1 Lgr1 CCAP CCAP Lgr3 Lgr3
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bossProtein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. (896 aa)
AstA-R2Allatostatin A receptor 2 (AstA-R2) encodes a receptor of the neuropeptide encoded by AstA. The interaction of both proteins modulates insulin and AKH signaling from cells of the corpus cardiaca; Belongs to the G-protein coupled receptor 1 family. (357 aa)
AdoRAdenosine receptor (AdoR) encodes a protein belongsING to the G protein-coupled receptor family (Class A) that functions via cAMP and PKA activation. It is involved in response to metabolic stress and neuromodulation. (774 aa)
Sap-rSaposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. (953 aa)
AstC-R1Allatostatin C receptor 1 (AstC-R1) encodes G-protein coupled receptor for the neuropeptide encoded by AstC. (483 aa)
AkhRAdipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. (455 aa)
fz3Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (646 aa)
CCKLR-17D3Cholecystokinin-like receptor at 17D3 (CCKLR-17D3) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Dsk. It acts through the cAMP-PKA-CREB pathway and it is needed for the growth of neuromuscular junctions. It regulates food ingestion, satiety, hyperactivity, aggression and escape-related locomotion. (584 aa)
CCKLR-17D1Cholecystokinin-like receptor at 17D1 (CCKLR-17D1) encodes a neuropeptide receptor involved in locomotion and neuromuscular junction growth; Belongs to the G-protein coupled receptor 1 family. (673 aa)
moodyG-protein coupled receptor moody; Isoform A and isoform B are required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug- related behaviors. Galphai and Galphao, and the regulator of G protein signaling, loco, are required in the surface glia to achieve effective insulation. The components function by regulating the cortical actin and thereby stabilizing the extended morphology of the surface glia, which in tu [...] (670 aa)
CCAP-RCardioacceleratory peptide receptor; Binds to the cardioactive peptide (CCAP), which is a neuropeptide; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (494 aa)
GABA-B-R1Metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways. (841 aa)
smogSmog, isoform D; Smog (smog) encodes a G-protein-coupled receptor with a key role in gastrulation. It contributes to cell intercalation and apical constriction via myosin II activation. (951 aa)
PK1-RPyrokinin-1 receptor; Receptor for the neuropeptide CAP-3/pyrokinin-1 (TGPSASSGLWFGPRL-amide). Also activated weakly by other neuropeptides terminating in the sequence PRL-amide including pyrokinin-2, Hug-gamma, and ecdysis-triggering-hormone-1. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. (430 aa)
NPFRNeuropeptide F receptor; Receptor for NPF. Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive eff [...] (489 aa)
PdfrPDF receptor; Pigment-dispersing factor receptor (Pdfr) encodes a G-Protein Coupled Receptor in the Family B class of GPCRs (Secretin Receptor-like) that can be activated by the product of Pdf. It has been implicated in regulation of circadian physiology, development of the flight motor system, and regulation of mating. (738 aa)
DroDrosocin (Dro) encodes an o-Glycosylated antibacterial peptide with activity against Gram-negative and Gram-positive bacteria. It is expressed in the fat body during the systemic immune response and is expressed in various epithelia. The expression of Dro is regulated at the transcriptional level mostly by the immune deficiency pathway; Belongs to the drosocin family. (64 aa)
Octalpha2RAlpha2-adrenergic-like octopamine receptor, isoform B; Heterotrimeric G-protein binding; octopamine receptor activity; G protein-coupled receptor activity; G protein-coupled amine receptor activity. It is involved in the biological process described with: cell-cell signaling; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; adenylate cyclase-activating adrenergic receptor signaling pathway; G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. (740 aa)
CrzRCorazonin receptor (CrzR) encodes a member of the Class A family of G-protein-coupled receptor that transduces the siganl of the neuropeptide encoded by Crz. It is involved in ethanol-induced behavior and ethanol metabolism. (644 aa)
fzFrizzled; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to inv [...] (612 aa)
Octbeta2ROctopamine receptor beta-2R; Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Essential for ovulation and fertilization. During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin- dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways. Positively regulates synaptic growth; an action that is antagonized by Octbeta1R. (630 aa)
MsR1Myosuppressin receptor 1 (MsR1) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Ms and acts through the adenylate cyclase-inhibiting GPCR signaling pathway. It inhibits visceral muscle contraction, and negatively regulates cardiac contractility and gut motility. (556 aa)
rkRickets (rk) encodes a G-protein coupled receptor that signals intracellularly using the second messenger cAMP. It binds the heterodimeric hormone bursicon and is developmentally important for molting-related behaviors. It is also required after adult emergence for cuticle hardening and melanization. (1360 aa)
OambOctopamine receptor Oamb; Receptor for octopamine (OA) which is a neurotransmitter, neurohormone and neuromodulator in invertebrates. Stimulates intracellular accumulation of cAMP and Ca(2+) following ligand binding. Required for ovulation. Following activation on mature follicle cells by OA, induces activity of the metalloprotease Mmp2 which leads to breakdown of the posterior follicle wall, resulting in ovulation. Ligand binding probably also leads to activation of CamKII which is also required for ovulation. Modulates sleep/wake behavior by acting in neurons of the pars intercerebra [...] (751 aa)
Octbeta1ROctopamine receptor beta-1R; Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Negatively regulates synaptic growth by activating the inhibitory G protein Galphao and limiting cAMP production. Antagonizes the action of Octbeta2R which stimulates synaptic growth. (508 aa)
CG31760Probable G-protein coupled receptor CG31760; G protein-coupled receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway. (1093 aa)
mthl11Probable G-protein coupled receptor Mth-like 11; G protein-coupled receptor activity. It is involved in the biological process described with: determination of adult lifespan; response to starvation; G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; Belongs to the G-protein coupled receptor 2 family. Mth subfamily. (532 aa)
sNPF-RShort neuropeptide F receptor (sNPF-R) encodes the G-protein-coupled receptor for the neuropeptide ligand encoded by sNPF, which utilizes the intracelluar ERK pathway or PKA-CREB pathway. It contributes to the regulation of growth, food intake, food-search behavior, appetitive memory, and sleep. (600 aa)
CalrCalreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). (406 aa)
ETHRETHR (ETHR) encodes two distinct G protein-coupled receptors through alternative splicing. During development, the receptors are essential in initiating the molt-related behaviors of ecdysis, and in adults they function to promote juvenile hormone signaling and reproduction. (471 aa)
CG12290Orphan GPCR CG12290; Alpha1-adrenergic receptor activity; G protein-coupled receptor activity. (798 aa)
SPRSex peptide receptor; Receptor for two functionally unrelated ligands; SP (A70A) for controlling reproductive behaviors and MIP for controlling sleep behavior. MIP-SPR pathway functions as a sleep homeostat which perceives the need for sleep and stabilizes it by providing a slow-acting inhibitory input to the fly arousal system that involve the pigment dispersing factor (pdf) neurons. SP-SPR is one of the multiple SP pathways that induce female post- mating behavioral responses (PMR) such as the suppression of mating receptivity and initiation of egg laying. The PMR switch is achieved [...] (435 aa)
CG4313Uncharacterized protein, isoform D; G protein-coupled receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway. (541 aa)
Lgr4Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) encodes a protein that shows highest similarity with vertebrate receptors for relaxin-like peptides. (809 aa)
Dop2RDopamine 2-like receptor (Dop2R) encodes a G protein-coupled receptor that is activated by dopamine. Postulated Dop2R-mediated functions include regulation of: aggression, cardiac function, feeding, levels of juvenile hormone and 20-hydroxyecdysone, lifespan, locomotor activity, nocturnal activity, olfactory associative learning, response to stress, sleep and sucrose acceptance. (905 aa)
GABA-B-R3Metabotropic GABA-B receptor subtype 3 (GABA-B-R3) encodes a G-protein coupled receptor for the GABA neurotransmitter that is coupled to the Go G protein and activation of phospholipase C. Activation of the product of GABA-B-R3 can inhibit neuronal activity. It functions in the olfactory system and in the regulation of sleep and circadian rhythms. (1305 aa)
TyrRIITyramine receptor II (TyrRII) encodes a Tyramine 3 class receptor. When heterologously expressed it shows a high affinity for both tyramine and phenylethylamine, and a lower affinity for a range of other related biogenic amines, in both the inhibition of adenylyl cyclase activity and in the release of calcium from internal stores; Belongs to the G-protein coupled receptor 1 family. (586 aa)
CG7497Uncharacterized protein, isoform B; G protein-coupled receptor activity. It is involved in the biological process described with: positive regulation of cytosolic calcium ion concentration; adenylate cyclase-activating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway. (412 aa)
TyrRTyramine receptor (TyrR) encodes a Tyramine 2 class receptor. When heterologously expressed it shows a very high specificity for the release of intercellular calcium by tyramine; Belongs to the G-protein coupled receptor 1 family. (631 aa)
AstC-R2Allatostatin C receptor 2 (AstC-R2) encodes G-protein coupled receptor for the neuropeptide encoded by AstC. (593 aa)
MsR2Myosuppressin receptor 2 (MsR2) encodes a G protein coupled receptor activated by the product of Ms (TDVDHVFLRFamide). It elevates neurotransmitter release in motor neurons and aids larval escape responses to light. (647 aa)
ProcProctolin, isoform A; Proctolin (Proc) encodes a neuropeptide precursor protein that binds the product of Proc-R and is involved in heart rate regulation. (140 aa)
CG13995Neuropeptide receptor activity; G protein-coupled receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; neuropeptide signaling pathway. (545 aa)
CapaRNeuropeptides capa receptor; Acts as a receptor for the neuropeptides CAP-1 and CAP-2, but not CAP-3. Probably a component of signal transduction pathway that leads to Malpighian tubule fluid secretion in response to these ligands. (477 aa)
LkrLeucokinin receptor (Lkr) encodes a 7-transmembrane domain G-protein-coupled receptor (GPCR) with the product of Lk as a ligand. It signals through intracellular calcium, and is implicated in ion regulation by the Malpighian tubules and in feeding control. (542 aa)
CNMaRCNMamide Receptor (CNMaR) encodes a G-protein coupled receptor for the neuropeptide encoded by CNMa. (480 aa)
Rh7Rhodopsin 7 (Rh7) encodes a visual photoreceptor involved in circadian light entrainment. (483 aa)
hecHector, isoform A; Hector (hec) encodes a G-protein coupled receptor involved in male courtship behavior. (486 aa)
AkhAdipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. (79 aa)
mthl10Probable G-protein coupled receptor Mth-like 10; G protein-coupled receptor activity. It is involved in the biological process described with: determination of adult lifespan; response to starvation; G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; Belongs to the G-protein coupled receptor 2 family. Mth subfamily. (585 aa)
mthG-protein coupled receptor Mth; Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up- regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro. Belongs to the G-protein coupled receptor 2 family. Mth subfamily. (522 aa)
CG13575FI22604p1; G protein-coupled receptor activity; neuropeptide receptor activity; G protein-coupled peptide receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway. (521 aa)
mAChR-CMuscarinic Acetylcholine Receptor, C-type (mAChR-C) encodes a G protein-coupled receptor activated by acetylcholine; Belongs to the G-protein coupled receptor 1 family. (371 aa)
Proc-RG protein-coupled receptor activity; proctolin receptor activity; neuropeptide receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; neuropeptide signaling pathway. (545 aa)
AstA-R1Allatostatin A receptor 1 (AstA-R1) encodes a G-protein coupled receptor for the neuropeptide encoded by AstA. (394 aa)
mAChR-BMuscarinic Acetylcholine Receptor, B-type (mAChR-B) encodes a G protein-coupled receptor activated by acetylcholine; Belongs to the G-protein coupled receptor 1 family. (1019 aa)
PK2-R1Pyrokinin 2 receptor 1 (PK2-R1) encodes a G protein-coupled receptor that binds the neuropeptide encoded by Hug with high affinity. After binding, a second messenger cascade is initiated in cells that are target for the product of Hug (mainly neurons of the central nervous system). (660 aa)
PK2-R2Pyrokinin 2 receptor 2 (PK2-R2) encodes a G protein-coupled receptor that binds the neuropeptide encoded by Hug with high affinity. After binding, a second messenger cascade is initiated in cells that are target for the product of Hug (mainly neurons of the central nervous system). (599 aa)
Lgr1Leucine-rich repeat-containing G protein-coupled receptor 1 (Lgr1) encodes a Leucine-rich repeat-containing G protein-coupled receptor (LGR type A) that shows highest similarity with vertebrate glycoprotein hormone (TSH and Thyrostimulin, FSH, LH ) receptors. (831 aa)
CCAPCrustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. (155 aa)
Lgr3Leucine-rich repeat-containing G protein-coupled receptor 3 (Lgr3) encodes a protein activated by the relaxin-like hormone encoded by Ilp8, which coordinates organ growth. (765 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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