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RpL22 RpL22 RpS6 RpS6 RpL29 RpL29 RpS24 RpS24 RpL39 RpL39 RpL19 RpL19 RpS15Aa RpS15Aa RpS10b RpS10b eIF3e eIF3e RpL14 RpL14 RpL13A RpL13A RpS25 RpS25 RpS19b RpS19b RpS27 RpS27 RpS10a RpS10a RpL32 RpL32 RpL6 RpL6 RpS18 RpS18 RpLP2 RpLP2 RpS15 RpS15 RpS23 RpS23 RpS15Ab RpS15Ab RpL31 RpL31 RpS8 RpS8 RpL15 RpL15 RpS3A RpS3A RpS2 RpS2 RpL21 RpL21 RpLP1 RpLP1 RpL18 RpL18 RpLP0 RpLP0 RpS29 RpS29 RpL40 RpL40 RpL3 RpL3 RpS19a RpS19a RpL9 RpL9 RpS9 RpS9 RpL7 RpL7 RpL5 RpL5 RpL36A RpL36A RpS30 RpS30 RpS3 RpS3 RpS13 RpS13 RpS26 RpS26 RpL26 RpL26 RpL23A RpL23A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RpL22Ribosomal protein L22 (RpL22) encodes a member of the eukaryotic ribosomal protein eL22 family. It is ubiquitously expressed, forms part of the large ribosomal subunit and is involved in protein synthesis. (299 aa)
RpS640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. (248 aa)
RpL2960S ribosomal protein L29; Chromatin binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL29 family. (76 aa)
RpS24Ribosomal protein S24 (RpS24) encodes an essential component of the small ribosomal subunit that functions in protein synthesis. It is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles; Belongs to the eukaryotic ribosomal protein eS24 family. (131 aa)
RpL3960S ribosomal protein L39; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
RpL19Ribosomal protein L19 (RpL19) encodes a ribosomal structural constituent; Belongs to the eukaryotic ribosomal protein eL19 family. (203 aa)
RpS15Aa40S ribosomal protein S15Aa; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the universal ribosomal protein uS8 family. (130 aa)
RpS10bRibosomal protein S10b (RpS10b) encodes a structural constituent of ribosomes; Belongs to the eukaryotic ribosomal protein eS10 family. (160 aa)
eIF3eEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In addition to its role in the eIF-3 complex, also functions in protein ubiquitination and degradation. During mitosis required for regulating mitotic mic [...] (435 aa)
RpL14Ribosomal protein L14 (RpL14) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL14 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. (166 aa)
RpL13ARibosomal protein L13A (RpL13A) encodes a component of the large ribosomal subunit, and thus involved in mRNA translation. Mutations in genes encoding ribosomal proteins affect fertility, viability and other Drosophila phenotypes, described as Minute; Belongs to the universal ribosomal protein uL13 family. (205 aa)
RpS2540S ribosomal protein S25; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eS25 family. (117 aa)
RpS19b40S ribosomal protein S19b; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal small subunit assembly; translation; Belongs to the eukaryotic ribosomal protein eS19 family. (155 aa)
RpS2740S ribosomal protein S27; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal small subunit assembly; translation. (84 aa)
RpS10a40S ribosomal protein S10a; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: ribosomal small subunit assembly; cytoplasmic translation. (163 aa)
RpL3260S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa)
RpL6Ribosomal protein L6, isoform B; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal large subunit assembly. (262 aa)
RpS18Ribosomal protein S18 (RpS18) encodes a ribosomal protein located at the top of the head of the 40S subunit and contacts several helices of the 18S rRNA. (152 aa)
RpLP260S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (113 aa)
RpS15Ribosomal protein S15 (RpS15) encodes a protein that plays a role in assembly, structure and function of the ribosome and functions in protein synthesis. It is phosphorylated by the kinase encoded by Lrrk, causing protein synthesis upregulation; Belongs to the universal ribosomal protein uS19 family. (148 aa)
RpS2340S ribosomal protein S23; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (143 aa)
RpS15Ab40S ribosomal protein S15Ab; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the universal ribosomal protein uS8 family. (130 aa)
RpL3160S ribosomal protein L31; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL31 family. (124 aa)
RpS8Ribosomal protein S8 (RpS8) encodes a structural constituent of ribosomes that is involved in larval lymph gland hemopoiesis; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
RpL1560S ribosomal protein L15; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL15 family. (204 aa)
RpS3ARibosomal protein S3A (RpS3A) encodes an essential component of the small ribosomal subunit that functions in protein synthesis. It is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles; Belongs to the eukaryotic ribosomal protein eS1 family. (268 aa)
RpS2Ribosomal protein S2 (RpS2) encodes a highly conserved component of the 40S ribolomal comlex. RpS2 product controls the assembly and nuclear export of the pre-ribosome and appears to have a specific function during oogenesis. (267 aa)
RpL21Ribosomal protein L21, isoform A; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (159 aa)
RpLP1Ribosomal protein LP1 (RpLP1) encodes a member of the cytoplasmic large ribosomal protein family. (112 aa)
RpL1860S ribosomal protein L18; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; translation. (188 aa)
RpLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10; Belongs to the universal ribosomal protein uL10 family. (317 aa)
RpS2940S ribosomal protein S29; Zinc ion binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation. (56 aa)
RpL40Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
RpL360S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes. (416 aa)
RpS19aRibosomal protein S19a (RpS19a) encodes a structural constituent of ribosomes; Belongs to the eukaryotic ribosomal protein eS19 family. (156 aa)
RpL9Ribosomal protein L9 (RpL9) encodes a ribosomal structural constituent; Belongs to the universal ribosomal protein uL6 family. (190 aa)
RpS9Ribosomal protein S9 (RpS9) encodes a structural constituent of ribosomes. (195 aa)
RpL760S ribosomal protein L7; Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). (252 aa)
RpL560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (299 aa)
RpL36ARibosomal protein L36A, isoform A; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL42 family. (104 aa)
RpS3040S ribosomal protein S30; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eS30 family. (132 aa)
RpS3Ribosomal protein S3 (RpS3) encodes a component of the small subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpS3 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. The product of RpS3 also contains a DNA lyase activity and functions in DNA repair. (246 aa)
RpS13Ribosomal protein S13 (RpS13) encodes a structural constituent of ribosomes; Belongs to the universal ribosomal protein uS15 family. (151 aa)
RpS2640S ribosomal protein S26; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation. (114 aa)
RpL26Ribosomal protein L26 (RpL26) encodes a protein component of large ribosomal subunits. (149 aa)
RpL23ARibosomal protein L23A (RpL23A) encodes an essential ribosomal RNA binding protein of the large ribosomal subunit involved in protein synthesis; Belongs to the universal ribosomal protein uL23 family. (277 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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