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AP-2alpha | AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP- 2alpha is a subunit of the plasma membrane adapter. (952 aa) | ||||
numb | Numb (numb) encodes a membrane-associated inhibitor of Notch signaling. It controls neuroblast and sense organ precursor asymmetric division. It is asymmetrically localized during mitosis and segregates exclusively to one of two daughter cells. (556 aa) | ||||
Eps-15 | Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation. (1253 aa) |