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IleRS-m IleRS-m eIF4EHP eIF4EHP betaTub56D betaTub56D RpL32 RpL32 amon amon bam bam twin twin osk osk pum pum eIF4E1 eIF4E1 Not1 Not1 Pop2 Pop2 Rpt3 Rpt3 mei-P26 mei-P26 ppk ppk IleRS IleRS tkv tkv me31B me31B hb hb eIF4E7 eIF4E7 T3dh T3dh CycB CycB CG5800 CG5800 zld zld eIF4E3 eIF4E3 eIF4E5 eIF4E5 eIF4E4 eIF4E4 bru1 bru1 Liprin-alpha Liprin-alpha bru2 bru2 eIF4E6 eIF4E6
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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IleRS-mIsoleucyl-tRNA synthetase, mitochondrial; tRNA binding; aminoacyl-tRNA editing activity; ATP binding; isoleucine-tRNA ligase activity. It is involved in the biological process described with: isoleucyl-tRNA aminoacylation; mitochondrial translation; Belongs to the class-I aminoacyl-tRNA synthetase family. (941 aa)
eIF4EHPEukaryotic translation initiation factor 4E homologous protein (eIF4EHP) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA and functions as a negative regulator of translation. The product of eIF4EHP contributes to embryonic patterning by negatively regulating translation of the products of cad and hb, and is also implicated in regulating ecdysone biosynthesis. (248 aa)
betaTub56DTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (456 aa)
RpL3260S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa)
amonAmontillado (amon) encodes a member of the Prohormone Convertase (PC) family of proteolytic enzymes. PCs generally recognize conserved basic amino acid sequences within protein precursors to direct catalysis of specific cleavage. amon product directly cleaves sli protein and may also target the propeptide encoded by Akh. It is also required for the production of bioactive neuropeptide hormones (e.g. those encoded by Hug, Crz, Ms, Capa and sNPF); Belongs to the peptidase S8 family. (654 aa)
bamBag of marbles (bam) encodes a protein involved in gametogenesis that is associated with the fusome, a germ cell-specific organelle. It contributes to the fate determination of germline stem cells, in which bam is negatively regulated by the BMP signaling pathway. (442 aa)
twinTwin, isoform C; Twin (twin) encodes the CCR4 deadenylase, one of two enzymes in the CCR4-NOT complex that degrade mRNA poly(A) tails. It is required during oogenesis in germline stem cell self-renewal, synchronous germ cell division and prevention of cell death, as well as in early embryonic patterning through the deadenylation of specific maternal mRNAs. (567 aa)
oskMaternal effect protein oskar; Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole. (606 aa)
pumMaternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...] (1533 aa)
eIF4E1Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family. (259 aa)
Not1Not1, isoform H; Not1 (Not1) encodes a poly(A)-specific ribonuclease involved in translation inhibition and ovarian follicle cell development. (2511 aa)
Pop2Pop2, isoform E; Pop2 (Pop2) encodes a poly(A)-specific ribonuclease involved in translation inhibition. (361 aa)
Rpt3Regulatory particle triple-A ATPase 3, isoform A; Proteasome-activating ATPase activity; ATPase activity; ATP binding. It is involved in the biological process described with: positive regulation of RNA polymerase II transcription preinitiation complex assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; protein catabolic process; Belongs to the AAA ATPase family. (413 aa)
mei-P26Meiotic P26, isoform F; Meiotic P26 (mei-P26) encodes a protein involved in meiosis, germline differentiation and spermatogenesis. (1310 aa)
ppkAmiloride-sensitive Na+ channel; Pickpocket (ppk) encodes an acid-sensing sodium channel from the degenerin/epithelial sodium channel (DEG/ENaC) family. It contributes to mechanical nociception, larval behavior and dendrite morphogenesis. (606 aa)
IleRSIsoleucyl-tRNA synthetase, isoform A; isoleucine-tRNA ligase activity; tRNA binding; aminoacyl-tRNA editing activity; ATP binding. It is involved in the biological process described with: isoleucyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (1229 aa)
tkvReceptor protein serine/threonine kinase; Thickveins (tkv) encodes a transforming growth factor beta type I receptor. Together with the product of put, it functions as a receptor of the product of dpp and therefore contributes to the BMP signaling pathway; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (575 aa)
me31BATP-dependent RNA helicase me31b; ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission. Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies. As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogene [...] (459 aa)
hbProtein hunchback; Gap class segmentation protein that controls development of head structures; Belongs to the hunchback C2H2-type zinc-finger protein family. (758 aa)
eIF4E7Eukaryotic translation initiation factor 4E7 (eIF4E7) encodes a protein involved in translational initiation. (429 aa)
T3dhProbable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. (464 aa)
CycBG2/mitotic-specific cyclin-B; Cyclin B (CycB) encodes a protein that binds to Cdk1, thereby promoting Cdk1's protein kinase activity. The complex CycB-Cdk1 complex induces the start of mitosis. During late metaphase of mitosis and continuing in G1, the product of CycB is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity, and allowing termination of mitosis. (530 aa)
CG5800ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: rRNA processing; larval somatic muscle development. (826 aa)
zldZelda, isoform A; Zelda (zld) encodes a zinc finger transcription factor that functions in early blastoderm development. It works as a zygotic genome activator because it has a global role in regulating early expressed genes, such as genes essential for cellularization, sex determination and pattern formation. It is also required at later times in development. (1596 aa)
eIF4E3Eukaryotic translation initiation factor 4E3 (eIF4E3) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. eIF4E3 is primarily expressed in testes and is required for male fertility, but not for viability. (244 aa)
eIF4E5Eukaryotic translation initiation factor 4E5 (eIF4E5) encodes a protein in translational initiation. (232 aa)
eIF4E4Eukaryotic translation initiation factor 4E4 (eIF4E4) encodes a protein involved in translational initiation. (229 aa)
bru1Bruno 1 (bru1) encodes an RNA binding protein acting in multiple forms of post-transcriptional gene regulation including repression and activation of translation and alternative splicing of pre-mRNAs. The product of bru1 is required for gametogenesis, developmental patterning, and muscle organization. (810 aa)
Liprin-alphaLiprin-alpha, isoform E; Liprin-alpha (Liprin-alpha) encodes a scaffolding protein that interacts with the receptor phosphatase Lar. It is involved in synapse morphogenesis and axon guidance. (1214 aa)
bru2Bruno 2, isoform E; RNA binding; mRNA binding. It is involved in the biological process described with: negative regulation of translation; mRNA splice site selection; regulation of alternative mRNA splicing, via spliceosome. (893 aa)
eIF4E6Eukaryotic translation initiation factor 4E6 (eIF4E6) encodes a RNA 7-methylguanosine cap binding protein. (173 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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