STRINGSTRING
CG9572 CG9572 N N nahoda nahoda cue cue slow slow C901 C901 Set2 Set2 yl yl Lrp4 Lrp4 Krn Krn Hml Hml Nrx-IV Nrx-IV CG7565 CG7565 CG32373 CG32373 vn vn ft ft CG11377 CG11377 Tsp Tsp grk grk NimC4 NimC4 NimB4 NimB4 NimB2 NimB2 spi spi Itgbn Itgbn CG7381 CG7381 Dl Dl arr arr wry wry NimB3 NimB3 CadN CadN LpR2 LpR2 Cubn Cubn NimC3 NimC3 frac frac LpR1 LpR1 Meltrin Meltrin NimA NimA crb crb uif uif CadN2 CadN2 NimB1 NimB1 eater eater Ten-m Ten-m stan stan sli sli CG42255 CG42255 dpy dpy kug kug axo axo drpr drpr Nrx-1 Nrx-1 dsd dsd CG44153 CG44153 Ndg Ndg SP2353 SP2353 shf shf mys mys mmd mmd trol trol mgl mgl CG15861 CG15861 NimB5 NimB5 NimC1 NimC1 NimC2 NimC2 Ser Ser eys eys Megf8 Megf8 CG31999 CG31999 LRP1 LRP1 Ten-a Ten-a
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
CG9572LP13770p. (441 aa)
NProcessed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] (2703 aa)
nahodaNahoda, isoform A. (1335 aa)
cueProtein cueball; Has a role in spermatogenesis and oogenesis. Might have a role in triglyceride homeostasis. Probably by regulating lipid storage and catabolism, plays a role in neuronal function. (644 aa)
slowSlowdown, isoform A; Slowdown (slow) encodes a protein secreted from tendon cells and is required for integrin-mediated muscle-tendon adhesion. (512 aa)
C901RT07140p1; Notch binding. It is involved in the biological process described with: cell communication. (559 aa)
Set2Probable histone-lysine N-methyltransferase CG1716; Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity). (2362 aa)
ylPutative vitellogenin receptor; Involved in uptake of vitellogenin by endocytosis. (1984 aa)
Lrp4LDL receptor related protein 4 (Lrp4) encodes a type I transmembrane protein that is enriched in presynaptic terminals and regulates synaptic organization in the olfactory circuit. (2009 aa)
KrnLD34429p; Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. (217 aa)
HmlHemolectin, isoform A; Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction. (3843 aa)
Nrx-IVNeurexin-4; Seems to play a role in the formation and function of septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation. Belongs to the neurexin family. (1284 aa)
CG7565FI19480p1. (1069 aa)
CG32373RE64043p; Calcium ion binding. It is involved in the biological process described with: synaptic target recognition. (486 aa)
vnVein (vn) encodes a secreted neuregulin-like EGFR ligand. It has weaker intrinsic activity, and a lower receptor affinity, than the TGFalpha-like ligand encoded by spi. It has roles in growth and patterning of tissues including muscle, midgut, ovary, trachea, glia, eye, leg, and wing. (623 aa)
ftCadherin-related tumor suppressor; Involved in regulation of planar cell polarity in the compound eye where it is required for correct specification of the R3 and R4 photoreceptor cells by regulating Fz activity in the R3/R4 precursor cells. This is likely to occur through creation of an ft gradient so that the equatorial R3/R4 precursor cell has a higher level of ft function than its polar neighbor. Also required for planar cell polarity of wing hairs. Mediates heterophilic cell adhesion in vitro and is required to stabilize ds on the cell surface. Involved in regulation of eye imagin [...] (5147 aa)
CG11377RE58433p; Calcium ion binding. (374 aa)
TspThrombospondin, isoform A; Thrombospondin (Tsp) is expressed in embryonic tendons and is regulated by sr. The product of Tsp serves as a ligand for the integrin subunit encoded by if and is required for muscle adhesion to tendons. (1060 aa)
grkProtein gurken; Critical for defining the anterior-posterior and dorsal- ventral axes of the egg. May signal directly to dorsal follicle cells through the receptor torpedo (top). During oogenesis this signaling pathway instructs follicle cells to follow a dorsal pathway of development rather than the default ventral pathway. (295 aa)
NimC4Nimrod C4 (NimC4) encodes a transmembrane phagocytic receptor that binds phosphatidylserine exposed on apoptotic cells. Its roles include recognition and engulfment of apoptotic cells during development. (377 aa)
NimB4Nimrod B4; It is involved in the biological process described with: defense response to bacterium. (448 aa)
NimB2Nimrod B2; It is involved in the biological process described with: defense response to bacterium; mesoderm development. (421 aa)
spiProtein spitz; Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination. (234 aa)
ItgbnIntegrin beta-nu; Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during emb [...] (799 aa)
CG7381FI17111p1. (712 aa)
DlNeurogenic locus protein delta; Acts as a ligand for Notch (N) receptor. Essential for proper differentiation of ectoderm. Dl is required for the correct separation of neural and epidermal cell lineages. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction. (833 aa)
arrLow-density lipoprotein receptor-related protein; Arrow (arr) encodes a type I trans-membrane protein and functions as an obligate co-receptor with the product of fz for the ligand encoded by wg in the canonical Wnt signaling pathway. The product of arr is involved in developmental patterning, cell survival and growth regulation; Belongs to the LDLR family. (1678 aa)
wryWeary, isoform B; Weary (wry) encodes a ligand for the receptor encoded by N. It is involved in the Notch signaling pathway and normal heart function. (1157 aa)
NimB3GEO11169p1; It is involved in the biological process described with: defense response to bacterium. (122 aa)
CadNNeural-cadherin; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information. (3101 aa)
LpR2Lipophorin receptor 2 (LpR2) encodes a transmembrane receptor. A subset of LpR2-encoded isoforms are involved in the cellular uptake of neutral lipids from the circulating protein encoded by apolpp. (1064 aa)
CubnCubilin homolog; Required in the nephrocyte for normal uptake of proteins and elimination of toxins, and for maintenance of endocytic trafficking structures. May function together with Amnionless. (3750 aa)
NimC3Nimrod C3 (NimC3) encodes a member of the highly conserved Nimrod cluster. It is a transmembrane protein with a putative phagocytosis receptor function. (224 aa)
fracFaulty attraction (frac) encodes an extracellular matrix protein that acts via an LIMK1- dependent BMP pathway to promote axon target recognition. The product of frac might be a proteolytic substrate of the matrix metalloproteinase encoded by Mmp2. (1618 aa)
LpR1Lipophorin receptor 1, isoform K; Lipophorin receptor 1 (LpR1) encodes a transmembrane receptor that regulates immune response by mediating clearance of the protein encoded by nec from the hemolymph. Some of the LpR1-encoded isoforms are also involved in the cellular uptake of neutral lipids from the circulating protein encoded by apolpp. (1076 aa)
MeltrinMeltrin (Meltrin) encodes an ADAM protein that belongs to the metzincin superfamily of metalloproteases. It is regulated by the homeobox protein encoded by vnd during embryonic development. (1407 aa)
NimANimrod A, isoform E; It is involved in the biological process described with: phagocytosis. (565 aa)
crbProtein crumbs; Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. Component of the crb-galla-Xpd (CGX) complex which is essential for prop [...] (2253 aa)
uifUninflatable, isoform C; Uninflatable (uif) encodes a single pass transmembrane protein that localizes to the apical plasma membrane in epithelial cells. It is required for embryonic tracheal maturation and tracheal growth in the larva. (3589 aa)
CadN2Putative neural-cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity). (1799 aa)
NimB1Nimrod B1, isoform B; It is involved in the biological process described with: defense response to bacterium. (403 aa)
eaterEater (eater) encodes a transmembrane receptor of the Nimrod family specifically expressed in hemocytes and required for the phagocytosis of Gram positive bacteria and the attachment of hemocytes to sessile niches. (1074 aa)
Ten-mTeneurin-m; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with Ten-a to organize neuromuscular synapses. Functions in olfactory synaptic partner matching by promoting homophilic cell adhesion between pre- synaptic olfactory receptor neurons (ORN) axons and post-synaptic projection neurons (PN) dendrites partner in the developing antennal lobe to form stable connections. Also [...] (3349 aa)
stanProtocadherin-like wing polarity protein stan; Involved in the fz signaling pathway that controls wing tissue polarity. Also mediates homophilic cell adhesion. May play a role in initiating prehair morphogenesis. May play a critical role in tissue polarity and in formation of normal dendrite fields. During planar cell polarity, stabilizes asymmetric PCP domains together with ATP6AP2. (3648 aa)
sliSlit (sli) encodes a secreted glycoprotein that acts as a ligand for the Robo receptor family and co-receptors, including the products of Sdc and Dscam1. The product of sli functions as second messenger (via Abl) and receptor dependent, providing repellent (neural growth cone), attractive (trachea), and polarising (cardioblasts) cues for differentiating cells. (2157 aa)
CG42255Uncharacterized protein; Calcium ion binding. (3613 aa)
dpyDumpy, isoform Q; Dumpy (dpy) encodes an extracellular protein involved in epidermal-cuticle attachment, aposition of wing surfaces and trachea development. (22949 aa)
kugFat-like cadherin-related tumor suppressor homolog; Required for the planar polarity of actin filament orientation at the basal side of ovarian follicle cells. Required for proper egg chamber shape and elongation of the egg chamber during oogenesis. Required for the correct planar polarization of Rab10 within the basal follicle cell epithelium and is therefore indirectly involved in the Rab10-dependent remodeling of the basal membrane during egg chamber elongation. (4699 aa)
axoAxotactin, isoform C; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: transmission of nerve impulse. (2179 aa)
drprProtein draper; Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria. Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis. Ligand-binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis. Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells. Required for the pha [...] (1042 aa)
Nrx-1Neurexin 1, isoform F; Neurexin 1 (Nrx-1) encodes a transmembrane synaptic adhesive molecule that regulates the synaptic architecture and function in the brain and neuromuscular junction. It contributes to synaptic growth, transmission, synaptic formation and also regulation of learning and memory, locomotion and visual function. (1847 aa)
dsdDistracted, isoform B; It is involved in the biological process described with: animal organ morphogenesis; synaptic target recognition; tissue development. (1323 aa)
CG44153Uncharacterized protein, isoform A; G protein-coupled receptor activity; cell-cell adhesion mediator activity. It is involved in the biological process described with: axon guidance; dendrite self-avoidance; homophilic cell adhesion via plasma membrane adhesion molecules. (1946 aa)
NdgNidogen; Cell adhesion glycoprotein which is widely distributed in basement membranes. Involved in cell-extracellular matrix (ECM) interactions probably by connecting the laminin and collagen IV networks. Required for permeability and mechanical stability of basement membranes, and ECM dependent neural plasticity. Not involved in assembly of the embryonic basement membrane. (1350 aa)
SP2353SP2353, isoform A; SP2353 (SP2353) encodes a EGF-like- and LamininG-domain-containing protein. It interacts genetically with Dg, which encodes a extracellular matrix receptor. It regulates muscle homeostasis, rhabdomere differentiation and innate immune response. (1361 aa)
shfProtein shifted; Required for normal accumulation and movement of lipid- modified hedgehog (hh) morphogen. May act by stabilizing the interaction between heparan sulfate proteoglycans (HSPGs) and hh, HSPGs being required for diffusion of hh morphogen. Not involved in wingless (wg) morphogen movement, suggesting that it may provide HSPG specificity for Hh. (460 aa)
mysIntegrin beta-PS; Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for m [...] (846 aa)
mmdMind-meld, isoform J; Metalloendopeptidase activity. It is involved in the biological process described with: membrane protein ectodomain proteolysis. (1484 aa)
trolTerribly reduced optic lobes (trol) encodes the extracellular matrix component Perlecan, a secreted heparan sulfate proteoglycan. It regulates cell-signaling by multiple growth factors including those in the hedgehog, wingless/WNT, FGF, TGFbeta, EGF, and VEGF families, thus playing a role in many developmental patterning decisions. (4479 aa)
mglMegalin, isoform A; Megalin (mgl) encodes a protein involved in cuticle development and endocytosis regulation. (4769 aa)
CG15861RE57840p. (205 aa)
NimB5Nimrod B5, isoform A; It is involved in the biological process described with: defense response to bacterium. (315 aa)
NimC1Nimrod C1, isoform B; It is involved in the biological process described with: defense response to bacterium; phagocytosis. (622 aa)
NimC2Nimrod C2, isoform B; It is involved in the biological process described with: phagocytosis. (701 aa)
SerProtein serrate; Acts as a ligand for Notch (N) receptor. Essential for proper ectodermal development. Serrate represents an element in a network of interacting molecules operating at the cell surface during the differentiation of certain tissues. (1407 aa)
eysProtein eyes shut; Essential for the formation of matrix-filled interrhabdomeral space: critical for the formation of epithelial lumina in the retina. Acts together with prominin (prom) and the cell adhesion molecule chaoptin (chp) to choreograph the partitioning of rhabdomeres into an open system. (2176 aa)
Megf8Multiple EGF like domains 8, isoform B; Calcium ion binding. It is involved in the biological process described with: tissue development; dendrite development; motor neuron axon guidance; animal organ morphogenesis. (2892 aa)
CG31999RE68558p; Calcium ion binding. It is involved in the biological process described with: extracellular matrix organization. (917 aa)
LRP1LDL receptor protein 1, isoform F; Calcium ion binding. (4752 aa)
Ten-aTeneurin-a; Tenascin accessory (Ten-a) encodes a type II dimeric transmembrane protein with a extracellular domain that mediates homophilic interactions with itself and with the product of Ten-m. It also interacts intracellularly with cytoskeleton regulatory proteins. It regulates axon guidance in embryonic nervous system, synaptic partner matching as well as synaptic organization in olfactory and neuromuscular systems. (3387 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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