(64 nodes) Pyrimidine metabolism, and Purine metabolism network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD12000	GD12000. (279 aa)
	DsimGD15152	GD15152. (291 aa)
	DsimGD15165	GD15165. (164 aa)
	DsimGD22671	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (191 aa)
	DsimGD21646	GD21646. (677 aa)
	DsimGD22044	GD22044. (394 aa)
	DsimGD23486	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (351 aa)
	DsimGD23515	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (158 aa)
	DsimGD23516	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (170 aa)
	DsimGD23517	GD23517. (264 aa)
	DsimGD22371	GD22371; Belongs to the adenylate kinase family. (412 aa)
	DsimGD22791	GD22791; Belongs to the GDA1/CD39 NTPase family. (464 aa)
	DsimGD22272	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (812 aa)
	DsimGD24163	GD24163. (264 aa)
	DsimGD23751	GD23751. (188 aa)
	DsimGD10747	GD10747. (790 aa)
	DsimGD11264	Uridine kinase; Belongs to the uridine kinase family. (625 aa)
	DsimGD11273	GD11273; Belongs to the 5'-nucleotidase family. (599 aa)
	DsimGD11274	GD11274; Belongs to the 5'-nucleotidase family. (585 aa)
	DsimGD11275	GD11275; Belongs to the 5'-nucleotidase family. (579 aa)
	DsimGD25021	GD25021. (339 aa)
	Adk2	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (240 aa)
	DsimGD11843	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (319 aa)
	DsimGD25418	GD25418. (211 aa)
	DsimGD25870	GD25870. (393 aa)
	DsimGD11395	GD11395. (360 aa)
	DsimGD25830	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily. (175 aa)
	DsimGD25095	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (378 aa)
	DsimGD12680	GD12680. (345 aa)
	DsimGD12145	GD12145. (188 aa)
	DsimGD14523	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (1013 aa)
	DsimGD13427	GD13427. (182 aa)
	DsimGD13387	GD13387. (396 aa)
	DsimGD12382	GD12382. (520 aa)
	DsimGD14257	GD14257. (250 aa)
	DsimGD14773	GD14773. (333 aa)
	DsimGD12741	GD12741; Belongs to the adenylate kinase family. (206 aa)
	DsimGD12739	GD12739; Belongs to the adenylate kinase family. (188 aa)
	DsimGD14864	GD14864. (187 aa)
	DsimGD18802	GD18802. (347 aa)
	DsimGD21086	GD21086. (260 aa)
	DsimGD16337	Nucleoside diphosphate kinase. (172 aa)
	DsimGD18755	GD18755. (420 aa)
	Adk3	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (209 aa)
	DsimGD19697	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (448 aa)
	DsimGD18150	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (253 aa)
	DsimGD18638	GD18638; Belongs to the NDK family. (387 aa)
	DsimGD18110	GD18110. (347 aa)
	DsimGD18595	GD18595. (337 aa)
	DsimGD20335	GD20335. (1256 aa)
	DsimGD20336	GD20336. (1241 aa)
	DsimGD20337	GD20337. (1220 aa)
	DsimGD20338	GD20338. (1083 aa)
	DsimGD17928	GD17928. (179 aa)
	DsimGD20479	GD20479. (502 aa)
	ry	Rosy. (903 aa)
	DsimGD16785	GD16785. (390 aa)
	DsimGD24378	GD24378. (1703 aa)
	DsimGD17001	GD17001. (190 aa)
	DsimGD16663	GD16663. (921 aa)
	DsimGD17175	Nucleoside diphosphate kinase. (151 aa)
	DsimGD16886	GD16886. (496 aa)
	DsimGD15638	GD15638. (403 aa)
	DsimGD16985	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (527 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adk2	DsimGD10747	B4QBH8	B4QAL5	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD10747.	0.656
Adk2	DsimGD11273	B4QBH8	B4QAU6	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD11273; Belongs to the 5'-nucleotidase family.	0.656
Adk2	DsimGD11274	B4QBH8	B4QAU8	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD11274; Belongs to the 5'-nucleotidase family.	0.656
Adk2	DsimGD11275	B4QBH8	B4QAU9	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD11275; Belongs to the 5'-nucleotidase family.	0.656
Adk2	DsimGD11843	B4QBH8	B4QBK0	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.665
Adk2	DsimGD12145	B4QBH8	B4QJM2	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD12145.	0.925
Adk2	DsimGD12680	B4QBH8	B4QIY5	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD12680.	0.951
Adk2	DsimGD12739	B4QBH8	B4QR75	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD12739; Belongs to the adenylate kinase family.	0.939
Adk2	DsimGD12741	B4QBH8	B4QR74	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD12741; Belongs to the adenylate kinase family.	0.939
Adk2	DsimGD13387	B4QBH8	B4QNJ1	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD13387.	0.443
Adk2	DsimGD13427	B4QBH8	B4QN03	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD13427.	0.975
Adk2	DsimGD14257	B4QBH8	B4QP89	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD14257.	0.824
Adk2	DsimGD14523	B4QBH8	B4QKK0	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.528
Adk2	DsimGD15638	B4QBH8	B4R6Z2	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD15638.	0.650
Adk2	DsimGD16337	B4QBH8	B4QT92	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Nucleoside diphosphate kinase.	0.948
Adk2	DsimGD16663	B4QBH8	B4R486	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD16663.	0.413
Adk2	DsimGD16785	B4QBH8	B4R2A8	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD16785.	0.945
Adk2	DsimGD16886	B4QBH8	B4R6G8	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD16886.	0.478
Adk2	DsimGD17001	B4QBH8	B4R2R1	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GD17001.	0.656
Adk2	DsimGD17175	B4QBH8	B4R4U8	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Nucleoside diphosphate kinase.	0.945