(25 nodes) Preribosome, large subunit precursor, and Ribosomal large subunit biogenesis network (Musca domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1I8M0N9	Uncharacterized protein. (485 aa)
	A0A1I8M157	Uncharacterized protein. (259 aa)
	A0A1I8M4B2	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (818 aa)
	A0A1I8M4L4	Uncharacterized protein. (305 aa)
	A0A1I8M975	PUM-HD domain-containing protein. (723 aa)
	A0A1I8MCX0	Brix domain-containing protein. (413 aa)
	A0A1I8MDY8	Brix domain-containing protein. (314 aa)
	A0A1I8MF93	TRASH domain-containing protein. (191 aa)
	A0A1I8MTA5	Uncharacterized protein. (447 aa)
	A0A1I8MTR9	CP-type G domain-containing protein. (580 aa)
	A0A1I8MVC4	Uncharacterized protein. (630 aa)
	A0A1I8MXU1	Protein MAK16 homolog; Belongs to the MAK16 family. (347 aa)
	A0A1I8N076	Brix domain-containing protein. (356 aa)
	A0A1I8N0G9	Uncharacterized protein; Belongs to the DEAD box helicase family. (691 aa)
	A0A1I8N0R1	RRM domain-containing protein. (391 aa)
	A0A1I8N176	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa)
	A0A1I8N486	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (616 aa)
	A0A1I8N5B9	Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (843 aa)
	A0A1I8NAQ4	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (263 aa)
	A0A1I8NF26	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (923 aa)
	A0A1I8NIA1	Uncharacterized protein. (821 aa)
	T1PF30_MUSDO	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (674 aa)
	T1PGH7_MUSDO	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (652 aa)
	T1PJD2_MUSDO	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (346 aa)
	T1PJQ0_MUSDO	Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family. (428 aa)

Your Current Organism:

Musca domestica

NCBI taxonomy Id: 7370
Other names: house fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1I8M0N9	A0A1I8M157	A0A1I8M0N9	A0A1I8M157	Uncharacterized protein.	Uncharacterized protein.	0.948
A0A1I8M0N9	A0A1I8M4B2	A0A1I8M0N9	A0A1I8M4B2	Uncharacterized protein.	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.	0.996
A0A1I8M0N9	A0A1I8M4L4	A0A1I8M0N9	A0A1I8M4L4	Uncharacterized protein.	Uncharacterized protein.	0.953
A0A1I8M0N9	A0A1I8M975	A0A1I8M0N9	A0A1I8M975	Uncharacterized protein.	PUM-HD domain-containing protein.	0.846
A0A1I8M0N9	A0A1I8MCX0	A0A1I8M0N9	A0A1I8MCX0	Uncharacterized protein.	Brix domain-containing protein.	0.888
A0A1I8M0N9	A0A1I8MDY8	A0A1I8M0N9	A0A1I8MDY8	Uncharacterized protein.	Brix domain-containing protein.	0.986
A0A1I8M0N9	A0A1I8MF93	A0A1I8M0N9	A0A1I8MF93	Uncharacterized protein.	TRASH domain-containing protein.	0.974
A0A1I8M0N9	A0A1I8MTA5	A0A1I8M0N9	A0A1I8MTA5	Uncharacterized protein.	Uncharacterized protein.	0.804
A0A1I8M0N9	A0A1I8MTR9	A0A1I8M0N9	A0A1I8MTR9	Uncharacterized protein.	CP-type G domain-containing protein.	0.947
A0A1I8M0N9	A0A1I8MVC4	A0A1I8M0N9	A0A1I8MVC4	Uncharacterized protein.	Uncharacterized protein.	0.994
A0A1I8M0N9	A0A1I8MXU1	A0A1I8M0N9	A0A1I8MXU1	Uncharacterized protein.	Protein MAK16 homolog; Belongs to the MAK16 family.	0.872
A0A1I8M0N9	A0A1I8N076	A0A1I8M0N9	A0A1I8N076	Uncharacterized protein.	Brix domain-containing protein.	0.740
A0A1I8M0N9	A0A1I8N0G9	A0A1I8M0N9	A0A1I8N0G9	Uncharacterized protein.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.635
A0A1I8M0N9	A0A1I8N0R1	A0A1I8M0N9	A0A1I8N0R1	Uncharacterized protein.	RRM domain-containing protein.	0.989
A0A1I8M0N9	A0A1I8N176	A0A1I8M0N9	A0A1I8N176	Uncharacterized protein.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.837
A0A1I8M0N9	A0A1I8N486	A0A1I8M0N9	A0A1I8N486	Uncharacterized protein.	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family.	0.987
A0A1I8M0N9	A0A1I8N5B9	A0A1I8M0N9	A0A1I8N5B9	Uncharacterized protein.	Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family.	0.766
A0A1I8M0N9	A0A1I8NAQ4	A0A1I8M0N9	A0A1I8NAQ4	Uncharacterized protein.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.811
A0A1I8M0N9	A0A1I8NF26	A0A1I8M0N9	A0A1I8NF26	Uncharacterized protein.	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.742
A0A1I8M0N9	A0A1I8NIA1	A0A1I8M0N9	A0A1I8NIA1	Uncharacterized protein.	Uncharacterized protein.	0.923