(66 nodes) Ribosome biogenesis in eukaryotes network (Musca domestica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Predicted Interactions

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Your Input:
	A0A1I8M0T2	Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. (132 aa)
	A0A1I8M192	Exonuclease domain-containing protein. (215 aa)
	A0A1I8M2M1	Brix domain-containing protein. (297 aa)
	A0A1I8M4P7	Uncharacterized protein. (726 aa)
	A0A1I8M4R9	Uncharacterized protein. (340 aa)
	A0A1I8M4V9	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (605 aa)
	A0A1I8M6E3	Uncharacterized protein. (655 aa)
	A0A1I8M6N1	Tr-type G domain-containing protein. (1035 aa)
	A0A1I8M889	Uncharacterized protein. (383 aa)
	A0A1I8MA70	NTF2 domain-containing protein. (139 aa)
	A0A1I8MAH2	Exonuclease domain-containing protein. (1085 aa)
	A0A1I8MAS3	Bms1-type G domain-containing protein. (1176 aa)
	A0A1I8MB08	Importin N-terminal domain-containing protein. (1073 aa)
	A0A1I8MBT6	PUA domain-containing protein. (515 aa)
	A0A1I8MDY0	Exonuclease domain-containing protein. (995 aa)
	A0A1I8MEB2	Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (145 aa)
	A0A1I8MET4	Uncharacterized protein. (681 aa)
	A0A1I8MHE7	WD_REPEATS_REGION domain-containing protein. (932 aa)
	A0A1I8MIF6	PINc domain-containing protein. (200 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (245 aa)
	A0A1I8MIX0	Uncharacterized protein. (308 aa)
	A0A1I8MJH9	RIO domain-containing protein. (560 aa)
	A0A1I8MJK6	WD_REPEATS_REGION domain-containing protein. (527 aa)
	A0A1I8ML51	Uncharacterized protein. (251 aa)
	A0A1I8MMS7	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (127 aa)
	A0A1I8MNT4	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (521 aa)
	A0A1I8MP78	Nop domain-containing protein. (527 aa)
	A0A1I8MQB5	Uncharacterized protein. (972 aa)
	A0A1I8MRL7	Uncharacterized protein. (609 aa)
	A0A1I8MSB6	U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (674 aa)
	A0A1I8MSS4	WD_REPEATS_REGION domain-containing protein. (925 aa)
	A0A1I8MTR9	CP-type G domain-containing protein. (580 aa)
	A0A1I8MTX6	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily. (176 aa)
	A0A1I8MWB4	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (233 aa)
	A0A1I8MWB5	Uncharacterized protein. (828 aa)
	A0A1I8MYX1	Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5677 aa)
	A0A1I8MZD0	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (245 aa)
	A0A1I8MZF6	WD_REPEATS_REGION domain-containing protein. (1091 aa)
	A0A1I8MZH9	Uncharacterized protein. (814 aa)
	A0A1I8N057	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (964 aa)
	A0A1I8N0Q0	Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (207 aa)
	A0A1I8N2S0	BP28CT domain-containing protein. (2117 aa)
	A0A1I8N343	CP-type G domain-containing protein. (641 aa)
	A0A1I8N3C4	Utp12 domain-containing protein. (619 aa)
	A0A1I8N5Y1	Nop domain-containing protein. (506 aa)
	A0A1I8N6P3	Exonuclease domain-containing protein. (673 aa)
	A0A1I8N7H5	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (519 aa)
	A0A1I8N868	Uncharacterized protein. (512 aa)
	A0A1I8N8S0	RRM domain-containing protein. (265 aa)
	A0A1I8N921	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1005 aa)
	A0A1I8N9H2	Alba domain-containing protein. (262 aa)
	A0A1I8N9Q4	5'-3' exoribonuclease 1. (1499 aa)
	A0A1I8NBL1	Nucleolar protein 6. (1296 aa)
	A0A1I8NBQ4	Uncharacterized protein. (863 aa)
	A0A1I8NBZ7	Uncharacterized protein. (253 aa)
	A0A1I8NEI9	WD_REPEATS_REGION domain-containing protein. (787 aa)
	A0A1I8NFW0	S4 RNA-binding domain-containing protein. (181 aa)
	A0A1I8NGM3	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (480 aa)
	A0A1I8NHT7	Uncharacterized protein. (64 aa)
	A0A1I8NIB3	Uncharacterized protein. (1384 aa)
	T1P9R9_MUSDO	Protein kinase; Belongs to the protein kinase superfamily. (336 aa)
	T1PAV1_MUSDO	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
	T1PF30_MUSDO	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (674 aa)
	T1PGH7_MUSDO	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (652 aa)
	T1PGT4_MUSDO	Ribosomal protein L7Ae/L30e/S12e/Gadd47. (160 aa)
	T1PHP6_MUSDO	ATPase family associated protein. (1011 aa)

Your Current Organism:

Musca domestica

NCBI taxonomy Id: 7370
Other names: house fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1I8M0T2	A0A1I8MEB2	A0A1I8M0T2	A0A1I8MEB2	Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.	0.900
A0A1I8M0T2	A0A1I8MIX0	A0A1I8M0T2	A0A1I8MIX0	Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	Uncharacterized protein.	0.911
A0A1I8M0T2	A0A1I8N0Q0	A0A1I8M0T2	A0A1I8N0Q0	Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.	0.900
A0A1I8M0T2	A0A1I8N9H2	A0A1I8M0T2	A0A1I8N9H2	Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	Alba domain-containing protein.	0.915
A0A1I8M0T2	A0A1I8NBQ4	A0A1I8M0T2	A0A1I8NBQ4	Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	Uncharacterized protein.	0.900
A0A1I8M192	A0A1I8MAH2	A0A1I8M192	A0A1I8MAH2	Exonuclease domain-containing protein.	Exonuclease domain-containing protein.	0.938
A0A1I8M192	A0A1I8MDY0	A0A1I8M192	A0A1I8MDY0	Exonuclease domain-containing protein.	Exonuclease domain-containing protein.	0.938
A0A1I8M192	A0A1I8ML51	A0A1I8M192	A0A1I8ML51	Exonuclease domain-containing protein.	Uncharacterized protein.	0.422
A0A1I8M192	A0A1I8N6P3	A0A1I8M192	A0A1I8N6P3	Exonuclease domain-containing protein.	Exonuclease domain-containing protein.	0.938
A0A1I8M2M1	A0A1I8M4P7	A0A1I8M2M1	A0A1I8M4P7	Brix domain-containing protein.	Uncharacterized protein.	0.998
A0A1I8M2M1	A0A1I8M4R9	A0A1I8M2M1	A0A1I8M4R9	Brix domain-containing protein.	Uncharacterized protein.	0.991
A0A1I8M2M1	A0A1I8M4V9	A0A1I8M2M1	A0A1I8M4V9	Brix domain-containing protein.	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	0.402
A0A1I8M2M1	A0A1I8M889	A0A1I8M2M1	A0A1I8M889	Brix domain-containing protein.	Uncharacterized protein.	0.997
A0A1I8M2M1	A0A1I8MAS3	A0A1I8M2M1	A0A1I8MAS3	Brix domain-containing protein.	Bms1-type G domain-containing protein.	0.995
A0A1I8M2M1	A0A1I8MBT6	A0A1I8M2M1	A0A1I8MBT6	Brix domain-containing protein.	PUA domain-containing protein.	0.431
A0A1I8M2M1	A0A1I8MET4	A0A1I8M2M1	A0A1I8MET4	Brix domain-containing protein.	Uncharacterized protein.	0.869
A0A1I8M2M1	A0A1I8MHE7	A0A1I8M2M1	A0A1I8MHE7	Brix domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.986
A0A1I8M2M1	A0A1I8MIF6	A0A1I8M2M1	A0A1I8MIF6	Brix domain-containing protein.	PINc domain-containing protein.	0.972
A0A1I8M2M1	A0A1I8MJH9	A0A1I8M2M1	A0A1I8MJH9	Brix domain-containing protein.	RIO domain-containing protein.	0.795
A0A1I8M2M1	A0A1I8MJK6	A0A1I8M2M1	A0A1I8MJK6	Brix domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.983