(16 nodes) Mixed, incl. MET activates PI3K/AKT signaling, and Platelet-derived growth factor alpha-receptor activity network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSGRP00000001736	Protein tyrosine phosphatase non-receptor type 11b. (526 aa)
	ENSSGRP00000012920	Growth factor receptor-bound protein 2-like. (215 aa)
	ENSSGRP00000014118	GRB2-associated binding protein 1. (334 aa)
	ENSSGRP00000014199	SHC-transforming protein 1-like. (426 aa)
	ENSSGRP00000015112	Macrophage stimulating 1 receptor b. (1281 aa)
	LOC107593936	Tyrosine-protein phosphatase non-receptor type 11-like isoform X1. (607 aa)
	ENSSGRP00000027557	Growth factor receptor-bound protein 2-A isoform X1. (255 aa)
	ENSSGRP00000027786	Platelet-derived growth factor receptor alpha-like. (1076 aa)
	ENSSGRP00000038682	Son of sevenless homolog 2-like isoform X1. (1340 aa)
	ENSSGRP00000048958	Son of sevenless homolog 1-like. (828 aa)
	LOC107599382	SHC-transforming protein 3-like. (625 aa)
	gab1	GRB2-associated-binding protein 1 isoform X1. (774 aa)
	LOC107555100	GRB2-related adapter protein 2-like. (251 aa)
	ENSSGRP00000075071	Platelet-derived growth factor receptor alpha. (1061 aa)
	LOC107561023	Growth factor receptor-binding protein 2. (221 aa)
	ENSSGRP00000103039	Tyrosine-protein phosphatase non-receptor type 11. (534 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000001736	ENSSGRP00000012920	ENSSGRP00000001736	ENSSGRP00000012920	Protein tyrosine phosphatase non-receptor type 11b.	Growth factor receptor-bound protein 2-like.	0.886
ENSSGRP00000001736	ENSSGRP00000014118	ENSSGRP00000001736	ENSSGRP00000014118	Protein tyrosine phosphatase non-receptor type 11b.	GRB2-associated binding protein 1.	0.936
ENSSGRP00000001736	ENSSGRP00000014199	ENSSGRP00000001736	ENSSGRP00000014199	Protein tyrosine phosphatase non-receptor type 11b.	SHC-transforming protein 1-like.	0.653
ENSSGRP00000001736	ENSSGRP00000015112	ENSSGRP00000001736	ENSSGRP00000015112	Protein tyrosine phosphatase non-receptor type 11b.	Macrophage stimulating 1 receptor b.	0.755
ENSSGRP00000001736	ENSSGRP00000027557	ENSSGRP00000001736	ENSSGRP00000027557	Protein tyrosine phosphatase non-receptor type 11b.	Growth factor receptor-bound protein 2-A isoform X1.	0.886
ENSSGRP00000001736	ENSSGRP00000027786	ENSSGRP00000001736	ENSSGRP00000027786	Protein tyrosine phosphatase non-receptor type 11b.	Platelet-derived growth factor receptor alpha-like.	0.578
ENSSGRP00000001736	ENSSGRP00000038682	ENSSGRP00000001736	ENSSGRP00000038682	Protein tyrosine phosphatase non-receptor type 11b.	Son of sevenless homolog 2-like isoform X1.	0.808
ENSSGRP00000001736	ENSSGRP00000048958	ENSSGRP00000001736	ENSSGRP00000048958	Protein tyrosine phosphatase non-receptor type 11b.	Son of sevenless homolog 1-like.	0.808
ENSSGRP00000001736	ENSSGRP00000075071	ENSSGRP00000001736	ENSSGRP00000075071	Protein tyrosine phosphatase non-receptor type 11b.	Platelet-derived growth factor receptor alpha.	0.578
ENSSGRP00000001736	LOC107555100	ENSSGRP00000001736	ENSSGRP00000071721	Protein tyrosine phosphatase non-receptor type 11b.	GRB2-related adapter protein 2-like.	0.703
ENSSGRP00000001736	LOC107561023	ENSSGRP00000001736	ENSSGRP00000076839	Protein tyrosine phosphatase non-receptor type 11b.	Growth factor receptor-binding protein 2.	0.886
ENSSGRP00000001736	LOC107599382	ENSSGRP00000001736	ENSSGRP00000051249	Protein tyrosine phosphatase non-receptor type 11b.	SHC-transforming protein 3-like.	0.653
ENSSGRP00000001736	gab1	ENSSGRP00000001736	ENSSGRP00000062097	Protein tyrosine phosphatase non-receptor type 11b.	GRB2-associated-binding protein 1 isoform X1.	0.936
ENSSGRP00000012920	ENSSGRP00000001736	ENSSGRP00000012920	ENSSGRP00000001736	Growth factor receptor-bound protein 2-like.	Protein tyrosine phosphatase non-receptor type 11b.	0.886
ENSSGRP00000012920	ENSSGRP00000014118	ENSSGRP00000012920	ENSSGRP00000014118	Growth factor receptor-bound protein 2-like.	GRB2-associated binding protein 1.	0.974
ENSSGRP00000012920	ENSSGRP00000014199	ENSSGRP00000012920	ENSSGRP00000014199	Growth factor receptor-bound protein 2-like.	SHC-transforming protein 1-like.	0.992
ENSSGRP00000012920	ENSSGRP00000015112	ENSSGRP00000012920	ENSSGRP00000015112	Growth factor receptor-bound protein 2-like.	Macrophage stimulating 1 receptor b.	0.838
ENSSGRP00000012920	ENSSGRP00000027557	ENSSGRP00000012920	ENSSGRP00000027557	Growth factor receptor-bound protein 2-like.	Growth factor receptor-bound protein 2-A isoform X1.	0.902
ENSSGRP00000012920	ENSSGRP00000027786	ENSSGRP00000012920	ENSSGRP00000027786	Growth factor receptor-bound protein 2-like.	Platelet-derived growth factor receptor alpha-like.	0.970
ENSSGRP00000012920	ENSSGRP00000038682	ENSSGRP00000012920	ENSSGRP00000038682	Growth factor receptor-bound protein 2-like.	Son of sevenless homolog 2-like isoform X1.	0.993