(63 nodes) Positive regulation of epithelial to mesenchymal transition network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107594427	Lymphoid enhancer-binding factor 1-like. (371 aa)
	ENSSGRP00000037912	Transforming growth factor beta-1-like. (376 aa)
	LOC107569721	Midkine-B-like. (147 aa)
	ENSSGRP00000029869	SMAD family member 4b. (484 aa)
	ENSSGRP00000029484	annotation not available (269 aa)
	LOC107566293	Bone morphogenetic protein 2-like. (424 aa)
	LOC107551196	TGF-beta receptor type-2-like. (562 aa)
	LOC107587364	Disabled homolog 2-like isoform X1. (783 aa)
	LOC107569139	TGF-beta receptor type-2-like. (667 aa)
	ENSSGRP00000023695	Lysyl oxidase homolog 2B-like. (662 aa)
	Lef1	Lymphoid enhancer-binding factor 1. (343 aa)
	ENSSGRP00000022575	SMAD family member 4a. (499 aa)
	ENSSGRP00000019785	Transforming growth factor beta receptor 2a. (511 aa)
	tgfb2	Transforming growth factor beta-2. (411 aa)
	ENSSGRP00000010396	SMAD family member 4b. (464 aa)
	LOC107597220	Disabled homolog 2-like isoform X1. (805 aa)
	ENSSGRP00000009499	annotation not available (76 aa)
	LOC107559658	Mothers against decapentaplegic homolog 4 isoform X1. (550 aa)
	LOC107577119	Bone morphogenetic protein 2-like. (424 aa)
	ENSSGRP00000006399	annotation not available (125 aa)
	LOC107580862	BMP and activin membrane-bound inhibitor homolog. (148 aa)
	ENSSGRP00000004828	Bone morphogenetic protein 2-like. (346 aa)
	LOC107594963	Serine/threonine-protein kinase mTOR-like. (2549 aa)
	ENSSGRP00000003135	annotation not available (218 aa)
	LOC107549411	BMP and activin membrane-bound inhibitor homolog. (261 aa)
	LOC107587415	Lysyl oxidase-like protein 2/3/4. (637 aa)
	LOC107549932	Regulator of cell cycle RGCC-like. (167 aa)
	ENSSGRP00000104891	Mothers against decapentaplegic homolog 4-like. (571 aa)
	LOC107560118	Midkine-B-like. (169 aa)
	glipr2	Golgi-associated plant pathogenesis-related protein 1. (154 aa)
	tgfb3	Transforming growth factor beta-3. (381 aa)
	LOC107553706	Lysyl oxidase-like protein 2/3/4. (737 aa)
	ENSSGRP00000098989	Mothers against decapentaplegic homolog 4-like. (169 aa)
	ENSSGRP00000094876	Lysyl oxidase-like protein 2/3/4. (610 aa)
	LOC107589304	Transforming growth factor beta-1-like. (381 aa)
	ENSSGRP00000094346	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b. (162 aa)
	LOC107553608	Disabled homolog 2-like isoform X1. (683 aa)
	ENSSGRP00000089846	Transforming growth factor beta-3-like. (138 aa)
	ENSSGRP00000089801	Bone morphogenetic protein 4. (193 aa)
	ENSSGRP00000089762	Si:dkey-222b8.1. (527 aa)
	ENSSGRP00000084345	annotation not available (69 aa)
	LOC107554637	Midkine-B-like. (146 aa)
	LOC107566715	BMP and activin membrane-bound inhibitor homolog. (257 aa)
	LOC107592299	Zinc finger protein 703-like. (590 aa)
	BMP4	Bone morphogenetic protein 4-like. (400 aa)
	ENSSGRP00000076473	Si:dkey-90m5.4. (203 aa)
	ENSSGRP00000076363	Mothers against decapentaplegic homolog 4-like isoform X1. (573 aa)
	ENSSGRP00000073907	Interleukin-1 beta-like. (260 aa)
	LOC107589143	Transforming growth factor beta-2-like. (414 aa)
	LOC107549763	Regulator of cell cycle RGCC-like. (123 aa)
	LOC107561610	Disabled homolog 2-like isoform X1. (684 aa)
	LOC107598564	Transforming growth factor beta-1-like. (376 aa)
	ENSSGRP00000057455	annotation not available (242 aa)
	LOC107573058	Transforming growth factor beta-1. (380 aa)
	LOC107559986	Midkine-B-like. (147 aa)
	LOC107564227	Serine/threonine-protein kinase mTOR. (2552 aa)
	LOC107584374	BMP and activin membrane-bound inhibitor homolog. (261 aa)
	LOC107550085	Mothers against decapentaplegic homolog 4-like isoform X1. (571 aa)
	LOC107598937	Transforming growth factor beta-2-like. (411 aa)
	LOC107591185	Midkine-B-like. (155 aa)
	ENSSGRP00000040243	Transforming growth factor beta-2-like. (444 aa)
	LOC107600517	TGF-beta receptor type-2-like isoform X1. (558 aa)
	LOC107601951	Phospholipase A2 inhibitor-like. (327 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	ENSSGRP00000010396	ENSSGRP00000078686	ENSSGRP00000010396	Bone morphogenetic protein 4-like.	SMAD family member 4b.	0.649
BMP4	ENSSGRP00000022575	ENSSGRP00000078686	ENSSGRP00000022575	Bone morphogenetic protein 4-like.	SMAD family member 4a.	0.649
BMP4	ENSSGRP00000029869	ENSSGRP00000078686	ENSSGRP00000029869	Bone morphogenetic protein 4-like.	SMAD family member 4b.	0.649
BMP4	ENSSGRP00000076363	ENSSGRP00000078686	ENSSGRP00000076363	Bone morphogenetic protein 4-like.	Mothers against decapentaplegic homolog 4-like isoform X1.	0.619
BMP4	ENSSGRP00000089762	ENSSGRP00000078686	ENSSGRP00000089762	Bone morphogenetic protein 4-like.	Si:dkey-222b8.1.	0.619
BMP4	ENSSGRP00000098989	ENSSGRP00000078686	ENSSGRP00000098989	Bone morphogenetic protein 4-like.	Mothers against decapentaplegic homolog 4-like.	0.649
BMP4	ENSSGRP00000104891	ENSSGRP00000078686	ENSSGRP00000104891	Bone morphogenetic protein 4-like.	Mothers against decapentaplegic homolog 4-like.	0.619
BMP4	LOC107550085	ENSSGRP00000078686	ENSSGRP00000045624	Bone morphogenetic protein 4-like.	Mothers against decapentaplegic homolog 4-like isoform X1.	0.619
BMP4	LOC107559658	ENSSGRP00000078686	ENSSGRP00000007947	Bone morphogenetic protein 4-like.	Mothers against decapentaplegic homolog 4 isoform X1.	0.649
ENSSGRP00000003135	ENSSGRP00000010396	ENSSGRP00000003135	ENSSGRP00000010396	annotation not available	SMAD family member 4b.	0.649
ENSSGRP00000003135	ENSSGRP00000022575	ENSSGRP00000003135	ENSSGRP00000022575	annotation not available	SMAD family member 4a.	0.649
ENSSGRP00000003135	ENSSGRP00000029869	ENSSGRP00000003135	ENSSGRP00000029869	annotation not available	SMAD family member 4b.	0.649
ENSSGRP00000003135	ENSSGRP00000076363	ENSSGRP00000003135	ENSSGRP00000076363	annotation not available	Mothers against decapentaplegic homolog 4-like isoform X1.	0.619
ENSSGRP00000003135	ENSSGRP00000089762	ENSSGRP00000003135	ENSSGRP00000089762	annotation not available	Si:dkey-222b8.1.	0.619
ENSSGRP00000003135	ENSSGRP00000098989	ENSSGRP00000003135	ENSSGRP00000098989	annotation not available	Mothers against decapentaplegic homolog 4-like.	0.649
ENSSGRP00000003135	ENSSGRP00000104891	ENSSGRP00000003135	ENSSGRP00000104891	annotation not available	Mothers against decapentaplegic homolog 4-like.	0.619
ENSSGRP00000003135	LOC107550085	ENSSGRP00000003135	ENSSGRP00000045624	annotation not available	Mothers against decapentaplegic homolog 4-like isoform X1.	0.619
ENSSGRP00000003135	LOC107559658	ENSSGRP00000003135	ENSSGRP00000007947	annotation not available	Mothers against decapentaplegic homolog 4 isoform X1.	0.649
ENSSGRP00000004828	ENSSGRP00000010396	ENSSGRP00000004828	ENSSGRP00000010396	Bone morphogenetic protein 2-like.	SMAD family member 4b.	0.619
ENSSGRP00000004828	ENSSGRP00000022575	ENSSGRP00000004828	ENSSGRP00000022575	Bone morphogenetic protein 2-like.	SMAD family member 4a.	0.619