(43 nodes) Neurotrophin signaling pathway network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSGRP00000015446	Neurotrophic tyrosine kinase, receptor, type 2b. (585 aa)
	ENSSGRP00000022625	Uncharacterized protein LOC107551160. (356 aa)
	ENSSGRP00000026387	Rap guanine nucleotide exchange factor 2-like. (1518 aa)
	ENSSGRP00000027863	Rap guanine nucleotide exchange factor 6-like. (1188 aa)
	ENSSGRP00000034256	GDNF family receptor alpha-1-like. (368 aa)
	GFRA1	GDNF family receptor alpha-1-like isoform X1. (518 aa)
	LOC107556520	NTPase KAP family P-loop domain-containing protein 1-like isoform X1. (736 aa)
	ENSSGRP00000042784	BDNF/NT-3 growth factors receptor-like. (385 aa)
	ENSSGRP00000042787	Neurotrophic tyrosine kinase, receptor, type 2b. (545 aa)
	ENSSGRP00000047745	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1235 aa)
	LOC107598483	Protrudin-like isoform X1. (437 aa)
	LOC107599366	Rap guanine nucleotide exchange factor 1-like. (1099 aa)
	LOC107581544	GDNF family receptor alpha-1-like. (481 aa)
	LOC107566067	Nerve growth factor, beta. (226 aa)
	ENSSGRP00000102053	Si:dkey-253i9.4. (1266 aa)
	ENSSGRP00000097805	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1264 aa)
	ENSSGRP00000096550	High affinity nerve growth factor receptor-like. (619 aa)
	ENSSGRP00000093131	Rap guanine nucleotide exchange factor 1-like. (1080 aa)
	ENSSGRP00000091053	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1177 aa)
	NGF	Nerve growth factor, beta. (229 aa)
	LOC107554201	Nerve growth factor, beta. (229 aa)
	ENSSGRP00000089055	Rap guanine nucleotide exchange factor (GEF) 2. (1324 aa)
	ENSSGRP00000089004	Rap guanine nucleotide exchange factor (GEF) 6. (1454 aa)
	ENSSGRP00000088346	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1212 aa)
	LOC107584056	Neurotrophin-3-like. (261 aa)
	ENSSGRP00000083753	Neurotrophic tyrosine kinase, receptor, type 2a. (690 aa)
	ENSSGRP00000083118	Zinc finger, FYVE domain containing 27. (312 aa)
	ENSSGRP00000081380	Si:dkey-159a18.1. (708 aa)
	ENSSGRP00000078490	Rap guanine nucleotide exchange factor 2-like isoform X1. (1609 aa)
	ENSSGRP00000076310	LOW QUALITY PROTEIN: nerve growth factor-like. (199 aa)
	ENSSGRP00000073390	LOW QUALITY PROTEIN: NT-3 growth factor receptor-like. (782 aa)
	ENSSGRP00000073310	Neurotrophic tyrosine kinase, receptor, type 3a. (783 aa)
	LOC107556800	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2-like. (135 aa)
	ENSSGRP00000070025	Neurotrophic tyrosine kinase, receptor, type 2a. (566 aa)
	LOC107579734	Neurotrophin-3-like. (261 aa)
	ENSSGRP00000054500	Rap guanine nucleotide exchange factor 1-like. (601 aa)
	anapc7	Rap guanine nucleotide exchange factor 1-like. (1029 aa)
	ENSSGRP00000008310	NTPase, KAP family P-loop domain containing 1. (551 aa)
	ENSSGRP00000007920	annotation not available (134 aa)
	LOC107577586	Uncharacterized protein LOC107577586. (204 aa)
	ENSSGRP00000004463	Neurotrophic tyrosine kinase, receptor type 3. (397 aa)
	ENSSGRP00000002664	High affinity nerve growth factor receptor-like. (620 aa)
	ENSSGRP00000017630	Neurotrophic tyrosine kinase, receptor type 3. (530 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000002664	ENSSGRP00000008310	ENSSGRP00000002664	ENSSGRP00000008310	High affinity nerve growth factor receptor-like.	NTPase, KAP family P-loop domain containing 1.	0.447
ENSSGRP00000002664	ENSSGRP00000054500	ENSSGRP00000002664	ENSSGRP00000054500	High affinity nerve growth factor receptor-like.	Rap guanine nucleotide exchange factor 1-like.	0.439
ENSSGRP00000002664	ENSSGRP00000076310	ENSSGRP00000002664	ENSSGRP00000076310	High affinity nerve growth factor receptor-like.	LOW QUALITY PROTEIN: nerve growth factor-like.	0.978
ENSSGRP00000002664	ENSSGRP00000093131	ENSSGRP00000002664	ENSSGRP00000093131	High affinity nerve growth factor receptor-like.	Rap guanine nucleotide exchange factor 1-like.	0.439
ENSSGRP00000002664	ENSSGRP00000096550	ENSSGRP00000002664	ENSSGRP00000096550	High affinity nerve growth factor receptor-like.	High affinity nerve growth factor receptor-like.	0.900
ENSSGRP00000002664	LOC107554201	ENSSGRP00000002664	ENSSGRP00000089981	High affinity nerve growth factor receptor-like.	Nerve growth factor, beta.	0.975
ENSSGRP00000002664	LOC107556520	ENSSGRP00000002664	ENSSGRP00000039145	High affinity nerve growth factor receptor-like.	NTPase KAP family P-loop domain-containing protein 1-like isoform X1.	0.447
ENSSGRP00000002664	LOC107566067	ENSSGRP00000002664	ENSSGRP00000112267	High affinity nerve growth factor receptor-like.	Nerve growth factor, beta.	0.979
ENSSGRP00000002664	LOC107579734	ENSSGRP00000002664	ENSSGRP00000056184	High affinity nerve growth factor receptor-like.	Neurotrophin-3-like.	0.945
ENSSGRP00000002664	LOC107584056	ENSSGRP00000002664	ENSSGRP00000088041	High affinity nerve growth factor receptor-like.	Neurotrophin-3-like.	0.945
ENSSGRP00000002664	LOC107599366	ENSSGRP00000002664	ENSSGRP00000049175	High affinity nerve growth factor receptor-like.	Rap guanine nucleotide exchange factor 1-like.	0.439
ENSSGRP00000002664	NGF	ENSSGRP00000002664	ENSSGRP00000090083	High affinity nerve growth factor receptor-like.	Nerve growth factor, beta.	0.979
ENSSGRP00000002664	anapc7	ENSSGRP00000002664	ENSSGRP00000051146	High affinity nerve growth factor receptor-like.	Rap guanine nucleotide exchange factor 1-like.	0.439
ENSSGRP00000004463	ENSSGRP00000008310	ENSSGRP00000004463	ENSSGRP00000008310	Neurotrophic tyrosine kinase, receptor type 3.	NTPase, KAP family P-loop domain containing 1.	0.447
ENSSGRP00000004463	ENSSGRP00000054500	ENSSGRP00000004463	ENSSGRP00000054500	Neurotrophic tyrosine kinase, receptor type 3.	Rap guanine nucleotide exchange factor 1-like.	0.439
ENSSGRP00000004463	ENSSGRP00000076310	ENSSGRP00000004463	ENSSGRP00000076310	Neurotrophic tyrosine kinase, receptor type 3.	LOW QUALITY PROTEIN: nerve growth factor-like.	0.548
ENSSGRP00000004463	ENSSGRP00000093131	ENSSGRP00000004463	ENSSGRP00000093131	Neurotrophic tyrosine kinase, receptor type 3.	Rap guanine nucleotide exchange factor 1-like.	0.439
ENSSGRP00000004463	LOC107554201	ENSSGRP00000004463	ENSSGRP00000089981	Neurotrophic tyrosine kinase, receptor type 3.	Nerve growth factor, beta.	0.766
ENSSGRP00000004463	LOC107556520	ENSSGRP00000004463	ENSSGRP00000039145	Neurotrophic tyrosine kinase, receptor type 3.	NTPase KAP family P-loop domain-containing protein 1-like isoform X1.	0.447
ENSSGRP00000004463	LOC107566067	ENSSGRP00000004463	ENSSGRP00000112267	Neurotrophic tyrosine kinase, receptor type 3.	Nerve growth factor, beta.	0.839