(36 nodes) (2018) Resveratrol Improves the Energy Sensing and Glycolipid Metabolism of Blunt Snout Bream Megalobrama amblycephala Fed High-Carbohydrate Diets by Activating the AMPK-SIRT1-PGC-1alpha Network. network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107598610	Glucose-6-phosphatase-like. (353 aa)
	LOC107551525	Elongation factor 1-alpha 2. (477 aa)
	LOC107560664	Glycogen phosphorylase, muscle form-like. (850 aa)
	PPARG-2	Peroxisome proliferator activated receptor gamma. (507 aa)
	LOC107563291	Glutamine synthetase-like. (371 aa)
	LOC107569358	Glutamine synthetase-like. (372 aa)
	LOC107554093	Glucose-6-phosphatase-like. (359 aa)
	LOC107557356	Glucose-6-phosphatase-like. (355 aa)
	ENSSGRP00000087506	Glucose-6-phosphate dehydrogenase. (425 aa)
	LOC107599231	Insulin-like. (108 aa)
	LOC107553065	Glycogen phosphorylase, brain form. (862 aa)
	LOC107600181	Insulin-like. (108 aa)
	LOC107562665	Glycogen phosphorylase, muscle form-like isoform X1. (854 aa)
	LOC107548798	Glutamine synthetase-like. (372 aa)
	LOC107548799	Glutamine synthetase-like isoform X1. (372 aa)
	LOC107565065	NAD-dependent protein deacetylase sirtuin-1-like isoform X1. (501 aa)
	LOC107591637	Elongation factor 1-alpha-like. (462 aa)
	LOC107553252	Glutamine synthetase-like. (390 aa)
	LOC107585334	Elongation factor 1-alpha 1-like. (491 aa)
	g6pc3	Glucose-6-phosphatase 3. (273 aa)
	ENSSGRP00000065033	Insulin. (175 aa)
	srebf1	Sterol regulatory element-binding transcription factor 1. (1134 aa)
	LOC107602754	Elongation factor 1-alpha 1. (462 aa)
	LOC107555380	Glutamine synthetase. (390 aa)
	LOC107561280	Insulin-like. (108 aa)
	ENSSGRP00000004729	Elongation factor 1-alpha 1-like. (89 aa)
	LOC107576494	Elongation factor 1-alpha 2-like. (515 aa)
	LOC107553219	Glycogen phosphorylase, liver form-like. (854 aa)
	LOC107589443	Elongation factor 1-alpha, somatic form-like. (462 aa)
	LOC107562394	NAD-dependent protein deacetylase sirtuin-1-like. (642 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma-like. (507 aa)
	acox1	Peroxisomal acyl-coenzyme A oxidase 1 isoform X1. (660 aa)
	ENSSGRP00000023587	Glycogen phosphorylase, muscle form-like isoform X1. (866 aa)
	ENSSGRP00000041632	acetyl-CoA carboxylase alpha. (2364 aa)
	LOC107595722	Glutamine synthetase-like. (372 aa)
	LOC107602977	Glycogen phosphorylase, liver form-like isoform X1. (854 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000023587	ENSSGRP00000065033	ENSSGRP00000023587	ENSSGRP00000065033	Glycogen phosphorylase, muscle form-like isoform X1.	Insulin.	0.506
ENSSGRP00000023587	LOC107548798	ENSSGRP00000023587	ENSSGRP00000101196	Glycogen phosphorylase, muscle form-like isoform X1.	Glutamine synthetase-like.	0.476
ENSSGRP00000023587	LOC107548799	ENSSGRP00000023587	ENSSGRP00000101317	Glycogen phosphorylase, muscle form-like isoform X1.	Glutamine synthetase-like isoform X1.	0.476
ENSSGRP00000023587	LOC107553065	ENSSGRP00000023587	ENSSGRP00000096014	Glycogen phosphorylase, muscle form-like isoform X1.	Glycogen phosphorylase, brain form.	0.901
ENSSGRP00000023587	LOC107553219	ENSSGRP00000023587	ENSSGRP00000007736	Glycogen phosphorylase, muscle form-like isoform X1.	Glycogen phosphorylase, liver form-like.	0.901
ENSSGRP00000023587	LOC107553252	ENSSGRP00000023587	ENSSGRP00000021444	Glycogen phosphorylase, muscle form-like isoform X1.	Glutamine synthetase-like.	0.474
ENSSGRP00000023587	LOC107554093	ENSSGRP00000023587	ENSSGRP00000082579	Glycogen phosphorylase, muscle form-like isoform X1.	Glucose-6-phosphatase-like.	0.485
ENSSGRP00000023587	LOC107555380	ENSSGRP00000023587	ENSSGRP00000000858	Glycogen phosphorylase, muscle form-like isoform X1.	Glutamine synthetase.	0.476
ENSSGRP00000023587	LOC107557356	ENSSGRP00000023587	ENSSGRP00000083822	Glycogen phosphorylase, muscle form-like isoform X1.	Glucose-6-phosphatase-like.	0.410
ENSSGRP00000023587	LOC107560664	ENSSGRP00000023587	ENSSGRP00000071137	Glycogen phosphorylase, muscle form-like isoform X1.	Glycogen phosphorylase, muscle form-like.	0.900
ENSSGRP00000023587	LOC107561280	ENSSGRP00000023587	ENSSGRP00000001489	Glycogen phosphorylase, muscle form-like isoform X1.	Insulin-like.	0.479
ENSSGRP00000023587	LOC107562665	ENSSGRP00000023587	ENSSGRP00000098650	Glycogen phosphorylase, muscle form-like isoform X1.	Glycogen phosphorylase, muscle form-like isoform X1.	0.900
ENSSGRP00000023587	LOC107563291	ENSSGRP00000023587	ENSSGRP00000074273	Glycogen phosphorylase, muscle form-like isoform X1.	Glutamine synthetase-like.	0.474
ENSSGRP00000023587	LOC107569358	ENSSGRP00000023587	ENSSGRP00000076508	Glycogen phosphorylase, muscle form-like isoform X1.	Glutamine synthetase-like.	0.476
ENSSGRP00000023587	LOC107595722	ENSSGRP00000023587	ENSSGRP00000044211	Glycogen phosphorylase, muscle form-like isoform X1.	Glutamine synthetase-like.	0.476
ENSSGRP00000023587	LOC107599231	ENSSGRP00000023587	ENSSGRP00000091706	Glycogen phosphorylase, muscle form-like isoform X1.	Insulin-like.	0.506
ENSSGRP00000023587	LOC107600181	ENSSGRP00000023587	ENSSGRP00000098019	Glycogen phosphorylase, muscle form-like isoform X1.	Insulin-like.	0.479
ENSSGRP00000023587	LOC107602977	ENSSGRP00000023587	ENSSGRP00000047632	Glycogen phosphorylase, muscle form-like isoform X1.	Glycogen phosphorylase, liver form-like isoform X1.	0.901
ENSSGRP00000023587	g6pc3	ENSSGRP00000023587	ENSSGRP00000057275	Glycogen phosphorylase, muscle form-like isoform X1.	Glucose-6-phosphatase 3.	0.418
ENSSGRP00000041632	ENSSGRP00000065033	ENSSGRP00000041632	ENSSGRP00000065033	acetyl-CoA carboxylase alpha.	Insulin.	0.422