(47 nodes) Regulation of macroautophagy network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2Y204_CIOIN	Uncharacterized protein. (246 aa)
	F6VK85_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (754 aa)
	LOC100179496	Sec1 family domain-containing protein 1; Belongs to the STXBP/unc-18/SEC1 family. (622 aa)
	F6W2R0_CIOIN	Uncharacterized protein. (249 aa)
	LOC100186582	Phosphoinositide 3-kinase regulatory subunit 4. (1337 aa)
	H2XJF2_CIOIN	Phosphatidylinositol 3-kinase catalytic subunit type 3. (931 aa)
	F6WU40_CIOIN	Ricin B-type lectin domain-containing protein. (789 aa)
	F6XUD5_CIOIN	Aminotran_1_2 domain-containing protein. (477 aa)
	F6V9F0_CIOIN	Aminotran_1_2 domain-containing protein. (343 aa)
	LOC100179839	Sorting nexin-4-like. (441 aa)
	F7A9G9_CIOIN	RING-type domain-containing protein. (966 aa)
	LOC100187265	Uncharacterized protein. (949 aa)
	F6UTD4_CIOIN	Vps5 domain-containing protein. (96 aa)
	F6U6A2_CIOIN	PX domain-containing protein. (255 aa)
	F6WPI9_CIOIN	FPL domain-containing protein. (803 aa)
	F7BL69_CIOIN	WD_REPEATS_REGION domain-containing protein. (598 aa)
	Zf(ring)-19	Uncharacterized protein. (722 aa)
	F6PQM2_CIOIN	PIPK domain-containing protein. (152 aa)
	F6PQJ9_CIOIN	PIPK domain-containing protein. (165 aa)
	F6ZAD3_CIOIN	Rap-GAP domain-containing protein. (1434 aa)
	F6T7E5_CIOIN	Uncharacterized protein. (478 aa)
	LOC100180438	Polymerase delta-interacting protein 2-like. (376 aa)
	F6R4D8_CIOIN	Rab-GAP TBC domain-containing protein. (590 aa)
	F6WN54_CIOIN	Uncharacterized protein. (965 aa)
	F6ZLD5_CIOIN	Protein kinase domain-containing protein. (164 aa)
	F6WK69_CIOIN	WD_REPEATS_REGION domain-containing protein. (805 aa)
	F6V7C2_CIOIN	Protein kinase domain-containing protein. (521 aa)
	Zf(fyve)-6	Uncharacterized protein. (1125 aa)
	F6SLD6_CIOIN	Deacetylase sirtuin-type domain-containing protein. (737 aa)
	Htt	Uncharacterized protein. (639 aa)
	LOC100179621	Short coiled-coil protein B-like. (120 aa)
	LOC100182401	Beclin 1-associated autophagy-related key regulator. (512 aa)
	LOC100178802	Transcription elongation factor SPT5. (1047 aa)
	H2XM17_CIOIN	FAT domain-containing protein. (187 aa)
	LOC100182592	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like. (202 aa)
	H2XMA8_CIOIN	Uncharacterized protein. (446 aa)
	H2XMY5_CIOIN	Uncharacterized protein. (281 aa)
	H2XPH2_CIOIN	DUF3385 domain-containing protein. (265 aa)
	H2XSM3_CIOIN	Uncharacterized protein. (291 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (268 aa)
	H2XV25_CIOIN	Uncharacterized protein. (652 aa)
	H2XWT8_CIOIN	Uncharacterized protein. (206 aa)
	H2XXY3_CIOIN	Uncharacterized protein. (1316 aa)
	H2XY78_CIOIN	Uncharacterized protein. (207 aa)
	H2Y066_CIOIN	Uncharacterized protein. (361 aa)
	LOC101242365	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (98 aa)
	H2Y0W5_CIOIN	FATC domain-containing protein. (201 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6R4D8_CIOIN	H2XXY3_CIOIN	ENSCINP00000018006	ENSCINP00000034517	Rab-GAP TBC domain-containing protein.	Uncharacterized protein.	0.474
F6SLD6_CIOIN	F6ZAD3_CIOIN	ENSCINP00000027486	ENSCINP00000014731	Deacetylase sirtuin-type domain-containing protein.	Rap-GAP domain-containing protein.	0.505
F6SLD6_CIOIN	LOC100182592	ENSCINP00000027486	ENSCINP00000030777	Deacetylase sirtuin-type domain-containing protein.	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like.	0.400
F6SLD6_CIOIN	atg5	ENSCINP00000027486	ENSCINP00000033358	Deacetylase sirtuin-type domain-containing protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.660
F6T7E5_CIOIN	F6WK69_CIOIN	ENSCINP00000015711	ENSCINP00000022500	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.812
F6T7E5_CIOIN	F6ZAD3_CIOIN	ENSCINP00000015711	ENSCINP00000014731	Uncharacterized protein.	Rap-GAP domain-containing protein.	0.424
F6U6A2_CIOIN	F6UTD4_CIOIN	ENSCINP00000011285	ENSCINP00000011281	PX domain-containing protein.	Vps5 domain-containing protein.	0.543
F6U6A2_CIOIN	LOC100179839	ENSCINP00000011285	ENSCINP00000009207	PX domain-containing protein.	Sorting nexin-4-like.	0.870
F6UTD4_CIOIN	F6U6A2_CIOIN	ENSCINP00000011281	ENSCINP00000011285	Vps5 domain-containing protein.	PX domain-containing protein.	0.543
F6UTD4_CIOIN	LOC100179839	ENSCINP00000011281	ENSCINP00000009207	Vps5 domain-containing protein.	Sorting nexin-4-like.	0.859
F6VK85_CIOIN	F6ZAD3_CIOIN	ENSCINP00000002868	ENSCINP00000014731	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Rap-GAP domain-containing protein.	0.623
F6VK85_CIOIN	H2XM17_CIOIN	ENSCINP00000002868	ENSCINP00000030699	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	FAT domain-containing protein.	0.943
F6VK85_CIOIN	H2XPH2_CIOIN	ENSCINP00000002868	ENSCINP00000031555	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DUF3385 domain-containing protein.	0.929
F6VK85_CIOIN	H2XV25_CIOIN	ENSCINP00000002868	ENSCINP00000033509	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.888
F6VK85_CIOIN	H2XWT8_CIOIN	ENSCINP00000002868	ENSCINP00000034122	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.925
F6VK85_CIOIN	H2Y066_CIOIN	ENSCINP00000002868	ENSCINP00000035300	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.929
F6VK85_CIOIN	H2Y0W5_CIOIN	ENSCINP00000002868	ENSCINP00000035549	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	FATC domain-containing protein.	0.893
F6VK85_CIOIN	LOC100187265	ENSCINP00000002868	ENSCINP00000009399	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.666
F6WK69_CIOIN	F6T7E5_CIOIN	ENSCINP00000022500	ENSCINP00000015711	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.812
F6WN54_CIOIN	H2XXY3_CIOIN	ENSCINP00000018722	ENSCINP00000034517	Uncharacterized protein.	Uncharacterized protein.	0.996