(13 nodes) Gamma-carboxyglutamic acid-rich (GLA) domain superfamily network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102345355	Uncharacterized protein. (276 aa)
	F10	Coagulation factor X. (475 aa)
	F7	Coagulation factor VII. (439 aa)
	PROZ	Protein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family. (431 aa)
	LOC102358409	Uncharacterized protein. (534 aa)
	PRRG1	Gla domain-containing protein. (232 aa)
	F9	Coagulation factor IX. (453 aa)
	PRRG3	Proline rich and Gla domain 3. (237 aa)
	GAS6	Uncharacterized protein. (681 aa)
	PROS1	Protein S. (677 aa)
	PROC	Uncharacterized protein. (444 aa)
	PRRG4	Proline rich and Gla domain 4. (229 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (618 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F10	F2	ENSLACP00000001289	ENSLACP00000021404	Coagulation factor X.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.822
F10	LOC102358409	ENSLACP00000001289	ENSLACP00000009670	Coagulation factor X.	Uncharacterized protein.	0.554
F2	F10	ENSLACP00000021404	ENSLACP00000001289	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor X.	0.822
F2	F7	ENSLACP00000021404	ENSLACP00000001961	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor VII.	0.821
F2	F9	ENSLACP00000021404	ENSLACP00000012201	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor IX.	0.801
F2	LOC102358409	ENSLACP00000021404	ENSLACP00000009670	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.983
F2	PROC	ENSLACP00000021404	ENSLACP00000017436	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.829
F2	PROZ	ENSLACP00000021404	ENSLACP00000003598	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Protein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family.	0.802
F7	F2	ENSLACP00000001961	ENSLACP00000021404	Coagulation factor VII.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.821
F7	LOC102358409	ENSLACP00000001961	ENSLACP00000009670	Coagulation factor VII.	Uncharacterized protein.	0.556
F9	F2	ENSLACP00000012201	ENSLACP00000021404	Coagulation factor IX.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.801
F9	LOC102358409	ENSLACP00000012201	ENSLACP00000009670	Coagulation factor IX.	Uncharacterized protein.	0.563
LOC102358409	F10	ENSLACP00000009670	ENSLACP00000001289	Uncharacterized protein.	Coagulation factor X.	0.554
LOC102358409	F2	ENSLACP00000009670	ENSLACP00000021404	Uncharacterized protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.983
LOC102358409	F7	ENSLACP00000009670	ENSLACP00000001961	Uncharacterized protein.	Coagulation factor VII.	0.556
LOC102358409	F9	ENSLACP00000009670	ENSLACP00000012201	Uncharacterized protein.	Coagulation factor IX.	0.563
LOC102358409	PROC	ENSLACP00000009670	ENSLACP00000017436	Uncharacterized protein.	Uncharacterized protein.	0.555
LOC102358409	PROS1	ENSLACP00000009670	ENSLACP00000016613	Uncharacterized protein.	Protein S.	0.846
LOC102358409	PROZ	ENSLACP00000009670	ENSLACP00000003598	Uncharacterized protein.	Protein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family.	0.572
PROC	F2	ENSLACP00000017436	ENSLACP00000021404	Uncharacterized protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.829