(50 nodes) Phosphatidylinositol-mediated signaling network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	W5LW37_LEPOC	Ras-GAP domain-containing protein. (183 aa)
	prr5l	Si:ch211-147k10.5. (355 aa)
	pik3ca	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1087 aa)
	LOC102684646	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	LOC107075842	PLC-beta_C domain-containing protein. (167 aa)
	pi4ka	Phosphatidylinositol 4-kinase, catalytic, alpha b; Belongs to the PI3/PI4-kinase family. (2102 aa)
	c1qbp	Complement component 1, q subcomponent binding protein. (289 aa)
	pik3c2a	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1703 aa)
	W5M5N6_LEPOC	Phosphoinositide phospholipase C. (1705 aa)
	plcl1	Phosphoinositide phospholipase C. (884 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (476 aa)
	W5MBC0_LEPOC	Neurofibromin 1b. (2820 aa)
	ca8	Carbonic anhydrase VIII; Belongs to the alpha-carbonic anhydrase family. (287 aa)
	W5MEN6_LEPOC	Phosphoinositide phospholipase C. (1409 aa)
	gab2	GRB2-associated binding protein 2. (677 aa)
	plce1	Phospholipase C, epsilon 1. (2331 aa)
	pten	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (417 aa)
	plcl2	Phosphoinositide phospholipase C. (1109 aa)
	npr3	Natriuretic peptide receptor 3. (527 aa)
	W5MJ15_LEPOC	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1075 aa)
	edn1	Endothelin 1. (200 aa)
	W5MPG8_LEPOC	Phosphatidylinositol 4-kinase, catalytic, beta; Belongs to the PI3/PI4-kinase family. (816 aa)
	LOC102693076	Transmembrane phosphatase with tensin homology. (513 aa)
	W5MQU6_LEPOC	Platelet endothelial aggregation receptor 1. (933 aa)
	plcd4	Phosphoinositide phospholipase C. (770 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (860 aa)
	nyap2	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2a. (711 aa)
	W5MU43_LEPOC	Phosphoinositide phospholipase C. (781 aa)
	gpr143	G protein-coupled receptor 143. (424 aa)
	htr2a	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (469 aa)
	plcd3	Phosphoinositide phospholipase C. (778 aa)
	LOC102683645	Peroxisome proliferator-activated receptor delta b. (438 aa)
	pik3c2b	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1588 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1285 aa)
	kbtbd2	Kelch repeat and BTB (POZ) domain containing 2. (621 aa)
	LOC102699081	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1091 aa)
	W5N7S4_LEPOC	NYAP_N domain-containing protein. (285 aa)
	W5N7Y0_LEPOC	Zgc:158659; Belongs to the PI3/PI4-kinase family. (902 aa)
	exoc1	Exocyst complex component 1. (901 aa)
	mtmr8	Myotubularin related protein 8. (694 aa)
	ogt	O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1. (1046 aa)
	PLCZ1	Phosphoinositide phospholipase C. (597 aa)
	pik3cg	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1105 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1190 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
	W5NJD2_LEPOC	G_PROTEIN_RECEP_F1_2 domain-containing protein. (374 aa)
	prr5	Proline rich 5a (renal). (404 aa)
	PIRT	Phosphoinositide interacting regulator of transient receptor potential channels. (132 aa)
	W5NP24_LEPOC	Platelet-activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (356 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102683645	ogt	ENSLOCP00000014290	ENSLOCP00000018276	Peroxisome proliferator-activated receptor delta b.	O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1.	0.405
LOC102684646	PLCB4	ENSLOCP00000002041	ENSLOCP00000020300	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.433
LOC102693076	LOC102699081	ENSLOCP00000010682	ENSLOCP00000016231	Transmembrane phosphatase with tensin homology.	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family.	0.768
LOC102693076	LOC107075842	ENSLOCP00000010682	ENSLOCP00000002289	Transmembrane phosphatase with tensin homology.	PLC-beta_C domain-containing protein.	0.538
LOC102693076	PLCB1	ENSLOCP00000010682	ENSLOCP00000020301	Transmembrane phosphatase with tensin homology.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.538
LOC102693076	PLCB2	ENSLOCP00000010682	ENSLOCP00000015843	Transmembrane phosphatase with tensin homology.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.538
LOC102693076	PLCB4	ENSLOCP00000010682	ENSLOCP00000020300	Transmembrane phosphatase with tensin homology.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.784
LOC102693076	PLCZ1	ENSLOCP00000010682	ENSLOCP00000018988	Transmembrane phosphatase with tensin homology.	Phosphoinositide phospholipase C.	0.555
LOC102693076	W5M5N6_LEPOC	ENSLOCP00000010682	ENSLOCP00000003694	Transmembrane phosphatase with tensin homology.	Phosphoinositide phospholipase C.	0.791
LOC102693076	W5MEN6_LEPOC	ENSLOCP00000010682	ENSLOCP00000006845	Transmembrane phosphatase with tensin homology.	Phosphoinositide phospholipase C.	0.791
LOC102693076	W5MJ15_LEPOC	ENSLOCP00000010682	ENSLOCP00000008374	Transmembrane phosphatase with tensin homology.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	0.692
LOC102693076	W5MU43_LEPOC	ENSLOCP00000010682	ENSLOCP00000011902	Transmembrane phosphatase with tensin homology.	Phosphoinositide phospholipase C.	0.555
LOC102693076	W5N7Y0_LEPOC	ENSLOCP00000010682	ENSLOCP00000016739	Transmembrane phosphatase with tensin homology.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.692
LOC102693076	pi4ka	ENSLOCP00000010682	ENSLOCP00000002641	Transmembrane phosphatase with tensin homology.	Phosphatidylinositol 4-kinase, catalytic, alpha b; Belongs to the PI3/PI4-kinase family.	0.792
LOC102693076	pik3c2a	ENSLOCP00000010682	ENSLOCP00000003495	Transmembrane phosphatase with tensin homology.	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family.	0.666
LOC102693076	pik3c2b	ENSLOCP00000010682	ENSLOCP00000014902	Transmembrane phosphatase with tensin homology.	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	0.666
LOC102693076	pik3c3	ENSLOCP00000010682	ENSLOCP00000011478	Transmembrane phosphatase with tensin homology.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.857
LOC102693076	pik3ca	ENSLOCP00000010682	ENSLOCP00000001277	Transmembrane phosphatase with tensin homology.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; Belongs to the PI3/PI4-kinase family.	0.692
LOC102693076	pik3cb	ENSLOCP00000010682	ENSLOCP00000005286	Transmembrane phosphatase with tensin homology.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.692
LOC102693076	pik3cg	ENSLOCP00000010682	ENSLOCP00000019486	Transmembrane phosphatase with tensin homology.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.768