STRINGSTRING
cyldl cyldl usp49 usp49 usp54b usp54b eif3f eif3f E7FC00_DANRE E7FC00_DANRE usp8 usp8 usp5 usp5 otud3 otud3 usp14 usp14 taf5l taf5l usp4 usp4 otud7b otud7b wdr48b wdr48b mindy3 mindy3 usp22 usp22 usp39 usp39 abraxas1 abraxas1 usp13 usp13 usp11 usp11 stambpa stambpa otub1a otub1a usp1 usp1 usp30 usp30 vcpip1 vcpip1 zranb1a zranb1a usp16 usp16 usp32 usp32 bap1 bap1 psmd14 psmd14 zranb1b zranb1b spata2 spata2 taf10 taf10 eny2 eny2 atxn7l3 atxn7l3 uchl3 uchl3 usp40 usp40 josd1 josd1 stambpl1 stambpl1 usp45 usp45 atxn7l2b atxn7l2b josd2 josd2 atxn7 atxn7 usp46 usp46 mindy1 mindy1 usp19 usp19 usp24 usp24 zc3h12a zc3h12a cylda cylda usp25 usp25 F8W526_DANRE F8W526_DANRE tnfaip3 tnfaip3 usp21 usp21 F1QW62_DANRE F1QW62_DANRE atxn7l2a atxn7l2a usp2a usp2a usp44 usp44 usp18 usp18 usp12a usp12a LOC100001665 LOC100001665 usp38 usp38 usp2b usp2b taf6l taf6l usp12b usp12b uchl1 uchl1 desi2 desi2 sf3b5 sf3b5 taf5 taf5 usp20 usp20 usp33 usp33 usp47 usp47 usp7 usp7 sgf29 sgf29 yod1 yod1 mindy2 mindy2 otub1b otub1b supt7l supt7l wdr48a wdr48a Usp15 Usp15 usp42 usp42 otud6b otud6b taf12 taf12 atxn7l1 atxn7l1 ENSDARP00000157149 ENSDARP00000157149 usp9 usp9 otud5a otud5a usp53b usp53b otulinb otulinb usp48 usp48 usp36 usp36 usp37 usp37 babam1 babam1 usp31 usp31 mindy4b mindy4b ENSDARP00000154050 ENSDARP00000154050 ENSDARP00000153534 ENSDARP00000153534 LOC794838 LOC794838 ENSDARP00000152229 ENSDARP00000152229 usp28 usp28 otud5b otud5b usp10 usp10 ENSDARP00000145175 ENSDARP00000145175 ENSDARP00000142992 ENSDARP00000142992 ENSDARP00000142721 ENSDARP00000142721 usp54a usp54a ENSDARP00000142408 ENSDARP00000142408 ENSDARP00000141807 ENSDARP00000141807 uchl5 uchl5 ENSDARP00000139356 ENSDARP00000139356 supt3h supt3h ENSDARP00000138881 ENSDARP00000138881 ENSDARP00000138860 ENSDARP00000138860 ENSDARP00000138685 ENSDARP00000138685 atxn3 atxn3 trrap trrap USP34 USP34 USP53 USP53 usp43a usp43a B8JJU9_DANRE B8JJU9_DANRE abraxas2 abraxas2 otud1 otud1 usp3 usp3 OTUD7A OTUD7A ENSDARP00000135851 ENSDARP00000135851 stambpb stambpb taf6 taf6 brcc3 brcc3 ENSDARP00000132612 ENSDARP00000132612 ENSDARP00000132583 ENSDARP00000132583 uimc1 uimc1 E7F4C8_DANRE E7F4C8_DANRE cyldb cyldb mysm1 mysm1 usp43b usp43b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cyldlCylindromatosis (turban tumor syndrome),-like; Belongs to the peptidase C19 family. (761 aa)
usp49Ubiquitin carboxyl-terminal hydrolase. (649 aa)
usp54bUbiquitin-specific peptidase 54b. (743 aa)
eif3fEukaryotic translation initiation factor 3, subunit F; Belongs to the eIF-3 subunit F family. (282 aa)
E7FC00_DANREAtaxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. (175 aa)
usp8Ubiquitin-specific peptidase 8; Belongs to the peptidase C19 family. (1067 aa)
usp5Ubiquitin carboxyl-terminal hydrolase. (834 aa)
otud3OTU deubiquitinase 3. (357 aa)
usp14Ubiquitin carboxyl-terminal hydrolase. (489 aa)
taf5lTAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (601 aa)
usp4Ubiquitin-specific peptidase 4 (proto-oncogene); Belongs to the peptidase C19 family. (1009 aa)
otud7bOTU deubiquitinase 7B. (917 aa)
wdr48bWD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (677 aa)
mindy3Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. (446 aa)
usp22Ubiquitin carboxyl-terminal hydrolase 22; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription (By similarity). (506 aa)
usp39Ubiquitin-specific peptidase 39. (497 aa)
abraxas1BRCA1-A complex subunit Abraxas 1; Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX [...] (391 aa)
usp13Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). (860 aa)
usp11Ubiquitin carboxyl-terminal hydrolase. (990 aa)
stambpaSTAM-binding protein-like A; Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes (By similarity). (418 aa)
otub1aUbiquitin thioesterase. (267 aa)
usp1Ubiquitin carboxyl-terminal hydrolase. (772 aa)
usp30Ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN). (491 aa)
vcpip1Valosin-containing protein (p97)/p47 complex-interacting protein 1. (1108 aa)
zranb1aZinc finger, RAN-binding domain-containing 1a. (666 aa)
usp16Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. (815 aa)
usp32Ubiquitin-specific peptidase 32; Belongs to the peptidase C19 family. (1585 aa)
bap1Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity). (755 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
zranb1bUbiquitin thioesterase zranb1-B; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. May play a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). (716 aa)
spata2Spermatogenesis-associated protein 2; Bridging factor that mediates the recruitment of cyld to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of cyld. (550 aa)
taf10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (181 aa)
eny2Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...] (95 aa)
atxn7l3Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. (367 aa)
uchl3Ubiquitin carboxyl-terminal hydrolase. (230 aa)
usp40Ubiquitin-specific peptidase 40; Belongs to the peptidase C19 family. (1263 aa)
josd1Josephin domain-containing 1. (235 aa)
stambpl1STAM-binding protein-like 1. (420 aa)
usp45Ubiquitin carboxyl-terminal hydrolase 45; May be involved in the maintenance of photoreceptor function. Belongs to the peptidase C19 family. (803 aa)
atxn7l2bAtaxin 7-like 2b. (666 aa)
josd2Josephin domain-containing 2. (184 aa)
atxn7Ataxin 7. (866 aa)
usp46Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity (By similarity). (370 aa)
mindy1Ubiquitin carboxyl-terminal hydrolase MINDY-1; Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. May play a regulatory role at the level of protein turnover; Belongs to the MINDY deubiquitinase family. FAM63 subfamily. (520 aa)
usp19Ubiquitin-specific peptidase 19. (1478 aa)
usp24Ubiquitin-specific peptidase 24. (1648 aa)
zc3h12aZinc finger CCCH-type-containing 12A. (367 aa)
cyldaCylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (951 aa)
usp25Ubiquitin-specific peptidase 25; Belongs to the peptidase C19 family. (1072 aa)
F8W526_DANRESi:dkey-30h22.11. (683 aa)
tnfaip3Tumor necrosis factor, alpha-induced protein 3. (756 aa)
usp21Ubiquitin carboxyl-terminal hydrolase. (404 aa)
F1QW62_DANRESi:ch211-165f21.4; Belongs to the peptidase C19 family. (595 aa)
atxn7l2aAtaxin 7-like 2a. (722 aa)
usp2aUbiquitin carboxyl-terminal hydrolase. (394 aa)
usp44Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key role in the spindle assembly checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity). (695 aa)
usp18Ubiquitin-specific peptidase 18; Belongs to the peptidase C19 family. (337 aa)
usp12aUbiquitin carboxyl-terminal hydrolase 12A; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity. (371 aa)
LOC100001665OTU deubiquitinase with linear linkage-specificity a. (858 aa)
usp38Ubiquitin-specific peptidase 38; Belongs to the peptidase C19 family. (1014 aa)
usp2bUbiquitin carboxyl-terminal hydrolase. (398 aa)
taf6lTAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (641 aa)
usp12bUbiquitin carboxyl-terminal hydrolase. (383 aa)
uchl1Ubiquitin carboxyl-terminal hydrolase. (218 aa)
desi2Deubiquitinase DESI2; Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'- linked polyubiquitin chains. (196 aa)
sf3b5Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
taf5TAF5 RNA polymerase II, TATA box-binding protein (TBP)-associated factor. (756 aa)
usp20Ubiquitin carboxyl-terminal hydrolase 20; Deubiquitinating enzyme involved in beta-2 adrenergic receptor (adrb2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (adrb2). Plays a central role in adrb2 recycling and resensitization after prolonged agonist stimulation by constitutively binding adrb2, mediating deubiquitination of adrb2 and inhibiting lysosomal trafficking of adrb2. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the pe [...] (911 aa)
usp33Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the ne [...] (897 aa)
usp47Ubiquitin-specific peptidase 47; Belongs to the peptidase C19 family. (1354 aa)
usp7Ubiquitin-specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1110 aa)
sgf29SAGA complex-associated factor 29. (293 aa)
yod1Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. A [...] (301 aa)
mindy2MINDY lysine 48 deubiquitinase 2. (625 aa)
otub1bUbiquitin thioesterase. (266 aa)
supt7lSuppressor of Ty 7 (S. cerevisiae)-like. (414 aa)
wdr48aWD repeat domain 48a. (524 aa)
Usp15DUSP domain-containing protein. (143 aa)
usp42Ubiquitin-specific peptidase 42; Belongs to the peptidase C19 family. (1168 aa)
otud6bDeubiquitinase OTUD6B; Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of different cellular processes. (293 aa)
taf12TAF12 RNA polymerase II, TATA box-binding protein (TBP)-associated factor. (162 aa)
atxn7l1Ataxin 7-like 1. (385 aa)
ENSDARP00000157149WD_REPEATS_REGION domain-containing protein. (519 aa)
usp9Ubiquitin-specific peptidase 9; Belongs to the peptidase C19 family. (2551 aa)
otud5aOTU domain-containing protein 5-A; Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (By similarity). (560 aa)
usp53bUbiquitin-specific peptidase 53b. (391 aa)
otulinbOTU deubiquitinase with linear linkage-specificity b. (409 aa)
usp48Ubiquitin-specific peptidase 48; Belongs to the peptidase C19 family. (1092 aa)
usp36Ubiquitin-specific peptidase 36; Belongs to the peptidase C19 family. (1104 aa)
usp37Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of APC/C target proteins, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex (By similarity); Belongs to the peptidase C19 family. (935 aa)
babam1BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cl [...] (370 aa)
usp31Ubiquitin-specific peptidase 31; Belongs to the peptidase C19 family. (1303 aa)
mindy4bMINDY family member 4B. (362 aa)
ENSDARP00000154050Reverse transcriptase domain-containing protein. (1080 aa)
ENSDARP00000153534Reverse transcriptase domain-containing protein. (1174 aa)
LOC794838DUF862 domain-containing protein. (198 aa)
ENSDARP00000152229USP domain-containing protein; Belongs to the peptidase C19 family. (141 aa)
usp28Ubiquitin-specific peptidase 28; Belongs to the peptidase C19 family. (1223 aa)
otud5bOTU deubiquitinase 5b. (537 aa)
usp10Ubiquitin carboxyl-terminal hydrolase. (898 aa)
ENSDARP00000145175USP domain-containing protein; Belongs to the peptidase C19 family. (338 aa)
ENSDARP00000142992Si:cabz01101003.1. (269 aa)
ENSDARP00000142721Ubiquitin carboxyl-terminal hydrolase. (519 aa)
usp54aUbiquitin-specific peptidase 54a. (1497 aa)
ENSDARP00000142408Si:ch73-223f5.2; Belongs to the peptidase C19 family. (592 aa)
ENSDARP00000141807Reverse transcriptase domain-containing protein. (1330 aa)
uchl5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
ENSDARP00000139356Reverse transcriptase domain-containing protein. (877 aa)
supt3hSPT3 homolog, SAGA and STAGA complex component. (380 aa)
ENSDARP00000138881Reverse transcriptase domain-containing protein. (1322 aa)
ENSDARP00000138860Si:ch211-149k12.3. (1259 aa)
ENSDARP00000138685Reverse transcriptase domain-containing protein. (1323 aa)
atxn3Ataxin 3. (311 aa)
trrapTransformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3841 aa)
USP34Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (2805 aa)
USP53USP domain-containing protein. (934 aa)
usp43aUbiquitin-specific peptidase 43a; Belongs to the peptidase C19 family. (1122 aa)
B8JJU9_DANRESi:dkey-206d17.12. (626 aa)
abraxas2Abraxas 2, BRISC complex subunit. (426 aa)
otud1OTU deubiquitinase 1. (412 aa)
usp3Ubiquitin carboxyl-terminal hydrolase. (524 aa)
OTUD7ASi:dkey-37f18.2. (943 aa)
ENSDARP00000135851Reverse transcriptase domain-containing protein. (1279 aa)
stambpbSTAM-binding protein b. (421 aa)
taf6TAF6 RNA polymerase II, TATA box-binding protein (TBP)-associated factor. (636 aa)
brcc3BRCA1/BRCA2-containing complex, subunit 3. (261 aa)
ENSDARP00000132612Reverse transcriptase domain-containing protein. (1307 aa)
ENSDARP00000132583Reverse transcriptase domain-containing protein. (1271 aa)
uimc1Uncharacterized protein. (524 aa)
E7F4C8_DANREReverse transcriptase domain-containing protein. (793 aa)
cyldbCylindromatosis (turban tumor syndrome), b. (694 aa)
mysm1Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). (822 aa)
usp43bUbiquitin-specific peptidase 43b; Belongs to the peptidase C19 family. (1183 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.