STRINGSTRING
recql5 recql5 rnf8 rnf8 nelfe nelfe eaf1 eaf1 ell2 ell2 LOC565819 LOC565819 cdk12 cdk12 si:ch73-61d6.3 si:ch73-61d6.3 zgc:154006 zgc:154006 nelfa nelfa leo1 leo1 wdr43 wdr43 ercc6 ercc6 supt16h supt16h cbx7b cbx7b brd4 brd4 cdk13 cdk13 eaf2 eaf2 gtf2f1 gtf2f1 supt6h supt6h zmynd11 zmynd11 eapp eapp nelfcd nelfcd trim33 trim33 ccnt1 ccnt1 ccnt2b ccnt2b ccnt2a ccnt2a cbx7a cbx7a supt5h supt5h ell ell rnf168 rnf168 ENSDARP00000153522 ENSDARP00000153522 supt4h1 supt4h1 nelfb nelfb sirt6 sirt6 pwwp2b pwwp2b cdc73 cdc73 pwwp2a pwwp2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
recql5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (933 aa)
rnf8E3 ubiquitin-protein ligase rnf8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53 [...] (531 aa)
nelfeNegative elongation factor complex member E. (346 aa)
eaf1ELL-associated factor 1. (253 aa)
ell2Elongation factor, RNA polymerase II, 2. (655 aa)
LOC565819Si:ch211-13k12.2. (593 aa)
cdk12Cyclin-dependent kinase 12. (1293 aa)
si:ch73-61d6.3Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (526 aa)
zgc:154006Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (537 aa)
nelfaNegative elongation factor complex member A. (542 aa)
leo1RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development. (696 aa)
wdr43WD repeat domain 43. (650 aa)
ercc6Excision repair cross-complementation group 6. (1389 aa)
supt16hSPT16 homolog, facilitates chromatin-remodeling subunit. (1033 aa)
cbx7bChromobox homolog 7b. (239 aa)
brd4Bromodomain-containing protein 4; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and rec [...] (1444 aa)
cdk13Cyclin-dependent kinase 13. (1289 aa)
eaf2ELL-associated factor 2. (259 aa)
gtf2f1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (536 aa)
supt6hTranscription elongation factor SPT6; Transcription elongation factor which binds histone H3 and enhances transcription elongation by RNA polymerase II (RNAPII). Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. Plays an important role during early patterning and somitogenesis of the embryo. (1726 aa)
zmynd11Zinc finger, MYND-type-containing 11. (640 aa)
eappE2f-associated phosphoprotein. (307 aa)
nelfcdNegative elongation factor complex member C/D. (579 aa)
trim33E3 ubiquitin-protein ligase TRIM33; May act as an E3 ubiquitin-protein ligase and a transcriptional repressor (By similarity). Involved in the regulation of embryonic and adult hematopoiesis. Required for normal development and survival of both committed erythroid progenitor cells and posterior mesenchymal cells. (1176 aa)
ccnt1Cyclin T1; Belongs to the cyclin family. (674 aa)
ccnt2bZgc:55690 protein; Belongs to the cyclin family. (569 aa)
ccnt2aCyclin T2a; Belongs to the cyclin family. (630 aa)
cbx7aChromobox homolog 7a. (395 aa)
supt5hTranscription elongation factor SPT5; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development. Belongs to the SPT [...] (1084 aa)
ellElongation factor RNA polymerase II. (660 aa)
rnf168E3 ubiquitin-protein ligase rnf168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (474 aa)
ENSDARP00000153522PWWP domain-containing protein. (194 aa)
supt4h1Transcription elongation factor SPT4; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development (By similarity). (117 aa)
nelfbNegative elongation factor complex member B. (609 aa)
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6 (S. cerevisiae). (354 aa)
pwwp2bPWWP domain-containing 2B. (597 aa)
cdc73Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (530 aa)
pwwp2aPWWP domain-containing 2A. (691 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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