STRINGSTRING
cdc20 cdc20 si:dkey-27n6.4 si:dkey-27n6.4 aurkaip1 aurkaip1 il1b il1b ENSDARP00000140829 ENSDARP00000140829 diabloa diabloa ENSDARP00000141204 ENSDARP00000141204 LOC100151049 LOC100151049 rnft2 rnft2 prkn prkn ENSDARP00000141773 ENSDARP00000141773 prelid1a prelid1a det1 det1 adgrg1-2 adgrg1-2 cln6a cln6a gramd4a gramd4a nop53 nop53 LOC110437957 LOC110437957 ENSDARP00000146183 ENSDARP00000146183 sox7 sox7 si:dkey-26m3.3 si:dkey-26m3.3 si:dkey-16p6.1-18 si:dkey-16p6.1-18 sfrp2l sfrp2l casp10 casp10 lgmn lgmn cntn2 cntn2 trib1 trib1 wu:fj30f06 wu:fj30f06 fbxw11a fbxw11a unm_hu7910 unm_hu7910 cln6b cln6b ENSDARP00000156746 ENSDARP00000156746 ENSDARP00000157149 ENSDARP00000157149 nkx3-1 nkx3-1 F1Q912_DANRE F1Q912_DANRE ENSDARP00000115194 ENSDARP00000115194 adrm1 adrm1 akirin2 akirin2 F2R F2R cidec cidec mul1b mul1b bbs7 bbs7 tmem259 tmem259 rnf217 rnf217 nrd1b nrd1b socs5b socs5b psmd14 psmd14 card9 card9 sirt1 sirt1 trib2 trib2 si:dkey-51d8.1 si:dkey-51d8.1 F6NUU8_DANRE F6NUU8_DANRE s100a10a s100a10a psmc6 psmc6 rnf139 rnf139 arih1l arih1l sh3rf1 sh3rf1 efna1a efna1a bag2 bag2 psme2 psme2 gramd4b gramd4b casp9 casp9 hpn hpn ptk2ab ptk2ab ccn1 ccn1 trib3 trib3 psmc4 psmc4 cycsb cycsb rnf144b rnf144b spon1b spon1b pdcd5 pdcd5 psmc1a psmc1a dab2 dab2 gsk3ba gsk3ba spon1a spon1a psmc3 psmc3 baxa baxa diablob diablob malt2 malt2 mul1a mul1a rnf144aa rnf144aa gclc gclc rnf14 rnf14 fbxw11b fbxw11b pdcd2 pdcd2 arl6ip5b arl6ip5b csnk1db csnk1db rhbdd1 rhbdd1 rnft1 rnft1 rchy1 rchy1 klhl40b klhl40b efna3a efna3a psme1 psme1 efna1b efna1b dnase1l4.2 dnase1l4.2 gsk3ab gsk3ab arih2 arih2 psmc2 psmc2 psmd10 psmd10 tnfb tnfb rad21a rad21a dnase1l4.1 dnase1l4.1 rnf19a rnf19a arih1 arih1 psme3 psme3 sart3 sart3 DMWD DMWD sirt2 sirt2 csnk1da csnk1da fzr1a fzr1a f3b f3b esco2 esco2 dap dap clul1 clul1 asph asph vsir vsir ccdc22 ccdc22 sfrp2 sfrp2 fn1b fn1b zyg11 zyg11 snx9a snx9a casp8 casp8 nub1 nub1 grnb grnb psmc5 psmc5 bcl2l11 bcl2l11 gba gba arl6ip5a arl6ip5a clec3ba clec3ba wdr20a wdr20a mapk9 mapk9 malt1 malt1 acer2 acer2 cop1 cop1 fbxw8 fbxw8 LOC558876 LOC558876 lpcat3 lpcat3 B0S6V5_DANRE B0S6V5_DANRE fmr1 fmr1 prr7 prr7 tnfrsf1b tnfrsf1b LOC110437942 LOC110437942 si:dkey-16p6.1 si:dkey-16p6.1 si:dkey-16p6.1-2 si:dkey-16p6.1-2 F2R-3 F2R-3 casp2 casp2 F2R-5 F2R-5 F1QD86_DANRE F1QD86_DANRE bada bada mkrn2 mkrn2 clu clu sh3d19 sh3d19 ngfra ngfra fn1a fn1a dda1 dda1 rnf144ab rnf144ab gsk3aa gsk3aa F1Q5P9_DANRE F1Q5P9_DANRE rnf19b rnf19b tp53 tp53 nrd1a nrd1a F1QPY4_DANRE F1QPY4_DANRE ankib1b ankib1b F1QLZ1_DANRE F1QLZ1_DANRE malt3 malt3 stub1 stub1 F1R571_DANRE F1R571_DANRE aifm1 aifm1 casp8ap2 casp8ap2 eif2ak3 eif2ak3 F1R3T6_DANRE F1R3T6_DANRE F1R5D8_DANRE F1R5D8_DANRE rad21b rad21b wdr20b wdr20b LOC560232 LOC560232 grna grna badb badb pcolce2b pcolce2b cflara cflara fas fas rad21l1 rad21l1 rnf180 rnf180 casp20 casp20 si:dkey-16p6.1-14 si:dkey-16p6.1-14 axin1 axin1 H0WEA7_DANRE H0WEA7_DANRE ctsc ctsc sirt6 sirt6 tank tank hip1rb hip1rb zgc:174944-3 zgc:174944-3 ripk2 ripk2 ENSDARP00000134209 ENSDARP00000134209 ENSDARP00000133818 ENSDARP00000133818 efna3b efna3b ENSDARP00000133576 ENSDARP00000133576 LOC101882060 LOC101882060 fgf2 fgf2 LOC108183680 LOC108183680 ankib1a ankib1a axin2 axin2 clpxa clpxa agbl4-2 agbl4-2 wdr48a wdr48a ENSDARP00000131837 ENSDARP00000131837 zer1 zer1 ptk2aa ptk2aa F1Q7D8_DANRE F1Q7D8_DANRE clec3bb clec3bb psme4a psme4a SH3RF3 SH3RF3 tmem130 tmem130 agbl4 agbl4 LOC101884563 LOC101884563 nupr1a nupr1a ENSDARP00000130165 ENSDARP00000130165 zgc:174944 zgc:174944 tmtc3 tmtc3 X1WE09_DANRE X1WE09_DANRE fzr1b fzr1b clpxb clpxb X1WC06_DANRE X1WC06_DANRE hip1 hip1 psme4b psme4b R4GEZ5_DANRE R4GEZ5_DANRE ptk2ba ptk2ba LOC100004321 LOC100004321 zgc:173709 zgc:173709 cyfip2 cyfip2 disc1 disc1 mbpb mbpb s100a10b s100a10b usp5 usp5 zc3h12a zc3h12a F1QGE7_DANRE F1QGE7_DANRE cflarb cflarb pidd1 pidd1 F1QV96_DANRE F1QV96_DANRE fbxo22 fbxo22 uacab uacab gsk3bb gsk3bb pcolceb pcolceb ist1 ist1 csnk1e csnk1e prelid1b prelid1b psmc1b psmc1b snx9b snx9b ctsh ctsh ptk2bb ptk2bb klhl40a klhl40a wdr48b wdr48b pycard pycard trim32 trim32 casp22 casp22 faslg faslg B8JJU9_DANRE B8JJU9_DANRE fbln1 fbln1 hspbp1 hspbp1 socs9 socs9 ENSDARP00000136668 ENSDARP00000136668 ENSDARP00000136722 ENSDARP00000136722 Wu:fy63c09 Wu:fy63c09 ENSDARP00000137135 ENSDARP00000137135 ENSDARP00000137199 ENSDARP00000137199 socs5a socs5a LOC108183940 LOC108183940 ogt.1 ogt.1 ENSDARP00000138564 ENSDARP00000138564 plgrkt plgrkt ogt.2 ogt.2 ENSDARP00000138756 ENSDARP00000138756 f3a f3a tfap4 tfap4 LOC108184002 LOC108184002 zgc:153993 zgc:153993 fadd fadd tnip1 tnip1 sh3rf2 sh3rf2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdc20Cell division cycle 20 homolog. (496 aa)
si:dkey-27n6.4Si:dkey-27n6.4. (1304 aa)
aurkaip1Aurora kinase A-interacting protein 1. (209 aa)
il1bInterleukin-1. (284 aa)
ENSDARP00000140829Si:dkey-261j11.2. (1223 aa)
diabloaDiablo, IAP-binding mitochondrial protein a. (265 aa)
ENSDARP00000141204Si:dkey-22a18.2. (1290 aa)
LOC100151049Lysosomal protein transmembrane 5. (215 aa)
rnft2Ring finger protein, transmembrane 2. (486 aa)
prknE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (458 aa)
ENSDARP00000141773Si:ch211-171l17.14. (1214 aa)
prelid1aPRELI domain-containing 1a. (210 aa)
det1DET1 partner of COP1 E3 ubiquitin ligase. (563 aa)
adgrg1-2Adhesion G protein-coupled receptor G1. (513 aa)
cln6aCLN6 transmembrane ER protein a. (298 aa)
gramd4aGRAM domain-containing 4a. (610 aa)
nop53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (473 aa)
LOC110437957CARD domain-containing protein. (201 aa)
ENSDARP00000146183Si:ch211-204c21.1. (697 aa)
sox7SRY-box transcription factor 7. (390 aa)
si:dkey-26m3.3Si:dkey-26m3.3. (1220 aa)
si:dkey-16p6.1-18Si:dkey-16p6.1. (1205 aa)
sfrp2lSecreted frizzled-related protein 2-like. (333 aa)
casp10Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (548 aa)
lgmnLegumain. (438 aa)
cntn2Contactin 2. (1040 aa)
trib1Tribbles pseudokinase 1. (349 aa)
wu:fj30f06Uncharacterized protein. (258 aa)
fbxw11aF-box and WD repeat domain-containing 11a. (562 aa)
unm_hu7910Un-named hu7910. (600 aa)
cln6bCLN6 transmembrane ER protein b. (310 aa)
ENSDARP00000156746RBR-type E3 ubiquitin transferase. (304 aa)
ENSDARP00000157149WD_REPEATS_REGION domain-containing protein. (519 aa)
nkx3-1NK3 homeobox 1. (214 aa)
F1Q912_DANRESi:dkey-261p22.1. (1179 aa)
ENSDARP00000115194Si:ch211-22k7.9. (1232 aa)
adrm1Proteasomal ubiquitin receptor ADRM1; Functions as a proteasomal ubiquitin receptor. Promotes the deubiquitinating activity associated with the 26S proteasome (By similarity); Belongs to the ADRM1 family. (411 aa)
akirin2Akirin 2. (180 aa)
F2RSi:dkey-163m14.2. (462 aa)
cidecCell death-inducing DFFA-like effector c. (239 aa)
mul1bMitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
bbs7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
tmem259Transmembrane protein 259. (694 aa)
rnf217RBR-type E3 ubiquitin transferase. (543 aa)
nrd1bNardilysin b (N-arginine dibasic convertase); Belongs to the peptidase M16 family. (1061 aa)
socs5bSuppressor of cytokine signaling 5-like. (557 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
card9Caspase recruitment domain family, member 9. (534 aa)
sirt1Sirtuin 1. (710 aa)
trib2Tribbles pseudokinase 2. (207 aa)
si:dkey-51d8.1Si:dkey-51d8.1. (1218 aa)
F6NUU8_DANRESi:dkey-196n19.2. (1166 aa)
s100a10aProtein S100; Belongs to the S-100 family. (102 aa)
psmc6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa)
rnf139Ring finger protein 139. (664 aa)
arih1lE3 ubiquitin-protein ligase arih1l; E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 ube2l3. (533 aa)
sh3rf1E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway; Belongs to the SH3RF family. (880 aa)
efna1aEphrin-A1a; Belongs to the ephrin family. (222 aa)
bag2BCL2-associated athanogene 2. (208 aa)
psme2Proteasome activator subunit 2. (244 aa)
gramd4bGRAM domain-containing 4b. (612 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa)
hpnNovel protein similar to H.sapiens HPN, hepsin (Transmembrane protease, serine 1) (HPN); Belongs to the peptidase S1 family. (425 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
ccn1Cellular communication network factor 1. (369 aa)
trib3Tribbles pseudokinase 3. (348 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
cycsbCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (104 aa)
rnf144bRBR-type E3 ubiquitin transferase. (312 aa)
spon1bSpondin 1b. (804 aa)
pdcd5Programmed cell death 5. (128 aa)
psmc1aProteasome (Prosome, macropain) 26S subunit, ATPase, 1a; Belongs to the AAA ATPase family. (440 aa)
dab2DAB adaptor protein 2. (589 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
spon1aSpondin 1a. (808 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (404 aa)
baxaBCL2-associated X, apoptosis regulator a. (192 aa)
diablobDiablo, IAP-binding mitochondrial protein b. (247 aa)
malt2MALT paracaspase 2. (806 aa)
mul1aMitochondrial ubiquitin ligase activator of nfkb 1-A; E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. (341 aa)
rnf144aaProbable E3 ubiquitin-protein ligase RNF144A-A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes ube2l3 and ube2l6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (293 aa)
gclcGlutamate-cysteine ligase, catalytic subunit. (631 aa)
rnf14RBR-type E3 ubiquitin transferase. (459 aa)
fbxw11bF-box and WD repeat domain-containing 11b. (531 aa)
pdcd2Programmed cell death 2. (358 aa)
arl6ip5bPRA1 family protein. (190 aa)
csnk1dbCasein kinase I isoform delta-B; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity). (409 aa)
rhbdd1Rhomboid domain-containing 1. (335 aa)
rnft1E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. (419 aa)
rchy1Ring finger and CHY zinc finger domain-containing 1. (264 aa)
klhl40bKelch-like protein 40b; ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development ; Belongs to the KLHL40 family. (618 aa)
efna3aEphrin-A3a; Belongs to the ephrin family. (220 aa)
psme1Proteasome activator subunit 1. (248 aa)
efna1bEphrin A-L1; Belongs to the ephrin family. (229 aa)
dnase1l4.2Deoxyribonuclease; Belongs to the DNase I family. (282 aa)
gsk3abGlycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (440 aa)
arih2RBR-type E3 ubiquitin transferase. (492 aa)
psmc2Proteasome (Prosome, macropain) 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
psmd10Proteasome 26S subunit, non-ATPase, 10. (226 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
rad21aDouble-strand-break repair protein rad21 homolog A; Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post- replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expressio [...] (643 aa)
dnase1l4.1Deoxyribonuclease 1-like 4, tandem duplicate 1. (288 aa)
rnf19aRBR-type E3 ubiquitin transferase. (913 aa)
arih1E3 ubiquitin-protein ligase arih1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin- protein ligase activity is activated upon binding to neddylated cullin- RING ubiquitin ligase com [...] (527 aa)
psme3Proteasome activator subunit 3. (256 aa)
sart3Squamous cell carcinoma antigen recognized by T-cells 3; U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. May also function as a substrate targeting factor for deubiquitinases and mediate the deubiquitination of components of the spliceosome and histones (By similarity). (951 aa)
DMWDZmp:0000000529. (684 aa)
sirt2NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (By similarity). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter. Thereby con [...] (379 aa)
csnk1daCasein kinase I isoform delta-A; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity). (403 aa)
fzr1aFizzy/cell division cycle 20 related 1 (Drosophila). (495 aa)
f3bCoagulation factor IIIb. (288 aa)
esco2N-acetyltransferase ESCO2; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (By similarity). Essential for early development. (609 aa)
dapDeath-associated protein. (105 aa)
clul1Clusterin; Belongs to the clusterin family. (466 aa)
asphAspartate beta-hydroxylase. (472 aa)
vsirV-set immunoregulatory receptor. (275 aa)
ccdc22Coiled-coil domain-containing protein 22; May be involved in regulation of NF-kappa-B signaling. May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity). (639 aa)
sfrp2Secreted frizzled-related protein 2. (294 aa)
fn1bFibronectin 1b. (2500 aa)
zyg11Protein zyg-11 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex zyg11-cul2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation. (746 aa)
snx9aSorting nexin. (562 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
nub1Negative regulator of ubiquitin-like proteins 1. (580 aa)
grnbGranulin b. (729 aa)
psmc5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
bcl2l11BCL2-like 11. (176 aa)
gbaGlucosylceramidase. (518 aa)
arl6ip5aPRA1 family protein. (190 aa)
clec3baC-type lectin domain family 3, member Ba. (197 aa)
wdr20aWD repeat domain 20a. (596 aa)
mapk9Mitogen-activated protein kinase. (421 aa)
malt1MALT paracaspase 1. (768 aa)
acer2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (277 aa)
cop1Novel protein similar to vertebrate ring finger and WD repeat domain 2 (RFWD2, zgc:163067). (694 aa)
fbxw8F-box and WD repeat domain-containing 8. (627 aa)
LOC558876RBR-type E3 ubiquitin transferase. (436 aa)
lpcat3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (465 aa)
B0S6V5_DANRESi:dkey-10c21.1. (254 aa)
fmr1FMRP translational regulator 1. (569 aa)
prr7Proline-rich 7 (synaptic). (245 aa)
tnfrsf1bTumor necrosis factor receptor superfamily, member 1B. (425 aa)
LOC110437942RBR-type E3 ubiquitin transferase. (397 aa)
si:dkey-16p6.1Si:dkey-16p6.1. (1205 aa)
si:dkey-16p6.1-2Si:dkey-16p6.1. (1220 aa)
F2R-3Si:dkey-163m14.4. (438 aa)
casp2Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (399 aa)
F2R-5Si:dkey-163m14.6. (411 aa)
F1QD86_DANRESi:ch211-212k18.15. (269 aa)
badaBCL2-associated agonist of cell death a. (145 aa)
mkrn2Probable E3 ubiquitin-protein ligase makorin-2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Inhibits neurogenesis and axis formation during embryonic development by modulating the phosphatidylinositol 3-kinase (PI3K) pathway. Acts downstream of PI3K and akt1 to up-regulate gsk3b mRNA expression. (414 aa)
cluClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
sh3d19SH3 domain-containing 19. (958 aa)
ngfraNerve growth factor receptor a (TNFR superfamily, member 16). (346 aa)
fn1aFibronectin 1a. (2480 aa)
dda1DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with cul4a and WD repeat proteins (By similarity); Belongs to the DDA1 family. (104 aa)
rnf144abProbable E3 ubiquitin-protein ligase RNF144A-B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes ube2l3 and ube2l6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (294 aa)
gsk3aaGlycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (462 aa)
F1Q5P9_DANRESi:ch211-214b16.4. (1489 aa)
rnf19bE3 ubiquitin-protein ligase RNF19B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death. (702 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
nrd1aNardilysin a (N-arginine dibasic convertase); Belongs to the peptidase M16 family. (1091 aa)
F1QPY4_DANRESi:ch211-214b16.3. (1330 aa)
ankib1bRBR-type E3 ubiquitin transferase. (1074 aa)
F1QLZ1_DANRESi:ch211-226o13.1. (1145 aa)
malt3MALT paracaspase 3. (627 aa)
stub1STIP1 homology and U-Box-containing protein 1. (287 aa)
F1R571_DANRESi:dkey-13n15.11. (1319 aa)
aifm1Apoptosis-inducing factor mitochondrion-associated 1. (750 aa)
casp8ap2Caspase 8-associated protein 2. (1995 aa)
eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1099 aa)
F1R3T6_DANRERBR-type E3 ubiquitin transferase. (611 aa)
F1R5D8_DANRESi:ch211-76m11.5. (1162 aa)
rad21bRAD21 cohesin complex component b. (637 aa)
wdr20bWD repeat domain 20b. (612 aa)
LOC560232Si:ch211-22k7.9. (1205 aa)
grnaGranulin a. (1049 aa)
badbBCL2-associated agonist of cell death b. (147 aa)
pcolce2bProcollagen C-endopeptidase enhancer 2b. (413 aa)
cflaraCASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family. (461 aa)
fasFas cell surface death receptor. (293 aa)
rad21l1RAD21 cohesin complex component-like 1. (546 aa)
rnf180Ring finger protein 180. (458 aa)
casp20Caspase 20, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (347 aa)
si:dkey-16p6.1-14Si:dkey-16p6.1. (1234 aa)
axin1Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa)
H0WEA7_DANRESi:dkey-56m15.2. (1260 aa)
ctscCathepsin C; Belongs to the peptidase C1 family. (455 aa)
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6 (S. cerevisiae). (354 aa)
tankTRAF family member-associated NFKB activator. (348 aa)
hip1rbHuntingtin-interacting protein 1-related b. (1065 aa)
zgc:174944-3Zgc:174944. (1104 aa)
ripk2Receptor-interacting serine-threonine kinase 2. (457 aa)
ENSDARP00000134209Si:ch1073-82l19.1. (732 aa)
ENSDARP00000133818Si:dkey-190j3.2. (1057 aa)
efna3bEphrin-A3b; Belongs to the ephrin family. (219 aa)
ENSDARP00000133576Si:ch211-227e10.3. (1158 aa)
LOC101882060Si:dkey-237g15.2. (1278 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
LOC108183680Si:dkeyp-4c4.2. (1173 aa)
ankib1aAnkyrin repeat and IBR domain-containing protein 1; Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. (1060 aa)
axin2Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. (812 aa)
clpxaCaseinolytic mitochondrial matrix peptidase chaperone subunit Xa. (624 aa)
agbl4-2ATP/GTP-binding protein-like 4. (202 aa)
wdr48aWD repeat domain 48a. (524 aa)
ENSDARP00000131837Si:dkey-279j5.1. (1301 aa)
zer1Zyg-11-related, cell cycle regulator. (774 aa)
ptk2aaProtein tyrosine kinase 2aa. (977 aa)
F1Q7D8_DANRESi:ch211-127b6.2. (1370 aa)
clec3bbC-type lectin domain family 3, member Bb. (200 aa)
psme4aProteasome activator complex subunit 4A; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved [...] (1876 aa)
SH3RF3Si:ch211-124n19.2. (602 aa)
tmem130Transmembrane protein 130. (318 aa)
agbl4ATP/GTP-binding protein-like 4. (225 aa)
LOC101884563Si:dkey-193i10.4. (1206 aa)
nupr1aNuclear protein 1a. (76 aa)
ENSDARP00000130165Si:dkey-31n13.4. (1142 aa)
zgc:174944Zgc:174944. (1180 aa)
tmtc3Transmembrane O-mannosyltransferase targeting cadherins 3. (932 aa)
X1WE09_DANRESi:dkey-23k10.2. (1074 aa)
fzr1bFizzy/cell division cycle 20-related 1b. (485 aa)
clpxbCaseinolytic mitochondrial matrix peptidase chaperone subunit Xb. (618 aa)
X1WC06_DANRESi:dkey-114l24.2. (205 aa)
hip1Huntingtin-interacting protein 1. (1046 aa)
psme4bProteasome activator complex subunit 4B; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved [...] (1845 aa)
R4GEZ5_DANRESi:zfos-364h11.2. (1175 aa)
ptk2baProtein tyrosine kinase 2 beta, a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (933 aa)
LOC100004321BCL2-associated X, apoptosis regulator a. (197 aa)
zgc:173709Si:dkey-156k2.3. (1310 aa)
cyfip2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1252 aa)
disc1DISC1 scaffold protein. (994 aa)
mbpbMyelin basic protein b. (133 aa)
s100a10bProtein S100; Belongs to the S-100 family. (100 aa)
usp5Ubiquitin carboxyl-terminal hydrolase. (834 aa)
zc3h12aZinc finger CCCH-type-containing 12A. (367 aa)
F1QGE7_DANRESi:ch211-196h16.4. (1057 aa)
cflarbCASP8 and FADD-like apoptosis regulator b. (178 aa)
pidd1P53-induced death domain protein 1. (942 aa)
F1QV96_DANRESi:dkey-250l23.4. (363 aa)
fbxo22Novel protein with F-box domain. (385 aa)
uacabUveal autoantigen with coiled-coil domains and ankyrin repeats b. (1371 aa)
gsk3bbGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa)
pcolcebSimilar to procollagen C-endopeptidase enhancer. (538 aa)
ist1IST1 factor-associated with ESCRT-III. (354 aa)
csnk1eCasein kinase 1, epsilon; Belongs to the protein kinase superfamily. (417 aa)
prelid1bPRELI domain-containing 1b. (199 aa)
psmc1bProteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa)
snx9bSorting nexin. (581 aa)
ctshCathepsin H; Belongs to the peptidase C1 family. (330 aa)
ptk2bbProtein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1004 aa)
klhl40aKelch-like protein 40a; ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development ; Belongs to the KLHL40 family. (612 aa)
wdr48bWD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (677 aa)
pycardApoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa- dependent apoptosis. In innate immune response acts as an integral adapter in the assembly of NLRP1 inflammasomes which activate caspases caspa and caspb leading to processing and secretion of the proinflammatory cytokine il1b. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved [...] (203 aa)
trim32Tripartite motif-containing 32. (663 aa)
casp22Caspase 22, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (376 aa)
faslgFas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (268 aa)
B8JJU9_DANRESi:dkey-206d17.12. (626 aa)
fbln1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (679 aa)
hspbp1HSPA (heat shock 70kDa)-binding protein, cytoplasmic cochaperone 1. (334 aa)
socs9Suppressor of cytokine-signaling 9. (497 aa)
ENSDARP00000136668Ncstrn_small domain-containing protein. (599 aa)
ENSDARP00000136722Si:dkeyp-35e5.5. (1232 aa)
Wu:fy63c09Uncharacterized protein. (698 aa)
ENSDARP00000137135Si:ch211-196f19.1. (1052 aa)
ENSDARP00000137199Si:dkey-165o8.2. (1233 aa)
socs5aSuppressor of cytokine-signaling 5a. (528 aa)
LOC108183940Si:ch211-258f1.3. (1229 aa)
ogt.1O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1. (1062 aa)
ENSDARP00000138564Si:ch211-268b14.2. (1144 aa)
plgrktPlasminogen receptor, C-terminal lysine transmembrane protein. (149 aa)
ogt.2O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1. (1102 aa)
ENSDARP00000138756Si:ch211-223g7.6. (1057 aa)
f3aCoagulation factor IIIa. (294 aa)
tfap4Transcription factor AP-4 (activating enhancer-binding protein 4). (335 aa)
LOC108184002Si:dkey-14o6.1. (1238 aa)
zgc:153993Zgc:153993 protein. (204 aa)
faddFas (tnfrsf6)-associated via death domain. (192 aa)
tnip1TNFAIP3-interacting protein 1. (653 aa)
sh3rf2SH3 domain-containing ring finger 2. (769 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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