STRINGSTRING
wdr45 wdr45 pip4k2aa pip4k2aa smcr8b smcr8b C13H9orf72 C13H9orf72 tmem39b tmem39b pink1 pink1 snx4 snx4 ift88 ift88 phf23a phf23a snx30 snx30 lrsam1 lrsam1 E7FBD4_DANRE E7FBD4_DANRE tbc1d12b tbc1d12b fez1 fez1 pip4k2ab pip4k2ab Q5RJ41_DANRE Q5RJ41_DANRE scfd1 scfd1 tbc1d14 tbc1d14 lrrk2 lrrk2 pikfyve pikfyve rab3gap2 rab3gap2 nupr1a nupr1a Tbc1d12a Tbc1d12a snx7 snx7 phf23b phf23b tmem39a tmem39a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
wdr45WD repeat domain phosphoinositide-interacting protein 4; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation; Belongs to the WD repeat SVP1 family. (358 aa)
pip4k2aaSimilar to type II phosphatidylinositolphosphate kinase-alpha. (404 aa)
smcr8bGuanine nucleotide exchange protein smcr8b; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. (985 aa)
C13H9orf72Zgc:100846. (462 aa)
tmem39bTransmembrane protein 39B. (491 aa)
pink1PTEN-induced kinase 1. (574 aa)
snx4Sorting nexin 4. (434 aa)
ift88Intraflagellar transport 88 homolog. (824 aa)
phf23aPHD finger protein 23A; Acts as a negative regulator of autophagy. (296 aa)
snx30Sorting nexin-30; May be involved in several stages of intracellular trafficking. (430 aa)
lrsam1Leucine-rich repeat and sterile alpha motif-containing 1. (721 aa)
E7FBD4_DANRESi:dkey-288i20.2. (376 aa)
tbc1d12bTBC1 domain family, member 12b. (771 aa)
fez1Fasciculation and Elongation protein zeta 1 (Zygin I). (394 aa)
pip4k2abPhosphatidylinositol-5-phosphate 4-kinase, type II, alpha b. (413 aa)
Q5RJ41_DANRESi:ch211-57i17.1. (339 aa)
scfd1Sec1 family domain-containing 1; Belongs to the STXBP/unc-18/SEC1 family. (632 aa)
tbc1d14TBC1 domain family, member 14. (711 aa)
lrrk2Leucine-rich repeat kinase 2. (2532 aa)
pikfyvePhosphatidylinositol phosphate 5-kinase type III isoform d. (2075 aa)
rab3gap2RAB3 GTPase-activating protein subunit 2 (non-catalytic). (1345 aa)
nupr1aNuclear protein 1a. (76 aa)
Tbc1d12aRab-GAP TBC domain-containing protein. (153 aa)
snx7Sorting nexin 7. (435 aa)
phf23bPHD finger protein 23B; Acts as a negative regulator of autophagy. (315 aa)
tmem39aTransmembrane protein 39A. (481 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.