STRINGSTRING
vangl2 vangl2 cdh2 cdh2 mmp2 mmp2 prickle2a prickle2a itgb3a itgb3a itgb3b itgb3b itga5 itga5 vangl1 vangl1 itgb1b.2 itgb1b.2 derl1 derl1 itgb1a itgb1a tbx1 tbx1 derl3 derl3 itgav itgav gapdhs gapdhs acta1b acta1b prickle1a prickle1a derl2 derl2 gapdh gapdh vtnb vtnb vtna vtna ryk ryk itgb5 itgb5 pxnb pxnb eea1 eea1 sec24b sec24b prickle1b prickle1b lamp1b lamp1b itgb1b.1 itgb1b.1 pxdn pxdn wnt5b wnt5b prickle2b prickle2b itgb1b itgb1b wnt5a wnt5a fzd6 fzd6 pxna pxna
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
vangl2Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
mmp2Matrix metalloproteinase 2. (657 aa)
prickle2aPrickle homolog 2a. (869 aa)
itgb3aIntegrin beta; Belongs to the integrin beta chain family. (785 aa)
itgb3bIntegrin beta; Belongs to the integrin beta chain family. (790 aa)
itga5Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Belongs to the integrin alpha chain family. (1053 aa)
vangl1Vang-like protein. (527 aa)
itgb1b.2Integrin beta; Belongs to the integrin beta chain family. (613 aa)
derl1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (261 aa)
itgb1aIntegrin beta; Belongs to the integrin beta chain family. (798 aa)
tbx1T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa)
derl3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (247 aa)
itgavIntegrin, alpha V; Belongs to the integrin alpha chain family. (1045 aa)
gapdhsGlyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. (335 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
prickle1aPrickle homolog 1a. (793 aa)
derl2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
vtnbVitronectin b. (449 aa)
vtnaVitronectin a. (514 aa)
rykReceptor-like tyrosine kinase. (604 aa)
itgb5Integrin beta; Belongs to the integrin beta chain family. (823 aa)
pxnbPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (525 aa)
eea1Early endosome antigen 1. (1398 aa)
sec24bSEC24 homolog B, COPII coat complex component. (1184 aa)
prickle1bPrickle homolog 1b. (863 aa)
lamp1bLysosomal-associated membrane protein 1b. (253 aa)
itgb1b.1Integrin beta; Belongs to the integrin beta chain family. (787 aa)
pxdnPeroxidasin. (1460 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
prickle2bPrickle homolog 2b. (840 aa)
itgb1bIntegrin beta; Belongs to the integrin beta chain family. (521 aa)
wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
fzd6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (617 aa)
pxnaPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (532 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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