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| atg101 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Belongs to the ATG101 family. (218 aa) | ||||
| smcr8b | Guanine nucleotide exchange protein smcr8b; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. (985 aa) | ||||
| vcp | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa) | ||||
| rae1 | mRNA export factor; Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Belongs to the WD repeat rae1 family. (368 aa) | ||||
| bcl2l1 | Bcl-XL-like protein 1. (238 aa) | ||||
| atg13 | Autophagy-related protein 13; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. (503 aa) | ||||
| hnrnpa1b | Heterogeneous nuclear ribonucleoprotein A1b. (403 aa) | ||||
| rcc1 | Regulator of chromosome condensation 1. (418 aa) | ||||
| srsf2a | Serine and arginine-rich-splicing factor 2a. (225 aa) | ||||
| grnb | Granulin b. (729 aa) | ||||
| puraa | Purine-rich element-binding protein Aa. (287 aa) | ||||
| wdr41 | WD repeat domain 41. (449 aa) | ||||
| hnrnpub | Heterogeneous nuclear ribonucleoprotein Ub. (796 aa) | ||||
| ulk1b | Unc-51-like autophagy-activating kinase 1. (1011 aa) | ||||
| grna | Granulin a. (1049 aa) | ||||
| adarb2 | Adenosine deaminase RNA-specific B2 (inactive). (739 aa) | ||||
| bcl2a | B-cell leukemia/lymphoma 2. (228 aa) | ||||
| sf1 | Splicing factor 1. (663 aa) | ||||
| alyref | Aly/REF export factor. (291 aa) | ||||
| hnrnpk | Heterogeneous nuclear ribonucleoprotein K. (429 aa) | ||||