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atg101 atg101 smcr8b smcr8b vcp vcp rae1 rae1 bcl2l1 bcl2l1 atg13 atg13 hnrnpa1b hnrnpa1b rcc1 rcc1 srsf2a srsf2a grnb grnb puraa puraa wdr41 wdr41 hnrnpub hnrnpub ulk1b ulk1b grna grna adarb2 adarb2 bcl2a bcl2a sf1 sf1 alyref alyref hnrnpk hnrnpk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
atg101Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Belongs to the ATG101 family. (218 aa)
smcr8bGuanine nucleotide exchange protein smcr8b; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. (985 aa)
vcpTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa)
rae1mRNA export factor; Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Belongs to the WD repeat rae1 family. (368 aa)
bcl2l1Bcl-XL-like protein 1. (238 aa)
atg13Autophagy-related protein 13; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. (503 aa)
hnrnpa1bHeterogeneous nuclear ribonucleoprotein A1b. (403 aa)
rcc1Regulator of chromosome condensation 1. (418 aa)
srsf2aSerine and arginine-rich-splicing factor 2a. (225 aa)
grnbGranulin b. (729 aa)
puraaPurine-rich element-binding protein Aa. (287 aa)
wdr41WD repeat domain 41. (449 aa)
hnrnpubHeterogeneous nuclear ribonucleoprotein Ub. (796 aa)
ulk1bUnc-51-like autophagy-activating kinase 1. (1011 aa)
grnaGranulin a. (1049 aa)
adarb2Adenosine deaminase RNA-specific B2 (inactive). (739 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
sf1Splicing factor 1. (663 aa)
alyrefAly/REF export factor. (291 aa)
hnrnpkHeterogeneous nuclear ribonucleoprotein K. (429 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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