STRINGSTRING
rxrgb rxrgb pck2 pck2 acsl4a acsl4a tnfrsf1a tnfrsf1a mapk8b mapk8b chuk chuk acsl4b acsl4b nfkbiab nfkbiab prkag1 prkag1 LOC100334818 LOC100334818 pck1 pck1 slc2a1a slc2a1a akt2 akt2 tnfa tnfa ikbkg ikbkg g6pc3 g6pc3 socs3a socs3a acsl1a acsl1a prkab1b prkab1b traf2a traf2a prkcq prkcq ptpn11b ptpn11b cd36 cd36 tradd tradd npy npy acsl2 acsl2 irs2a irs2a adipor1b adipor1b pomca pomca prkab1a prkab1a stk11 stk11 irs1 irs1 lepr lepr rxraa rxraa ptpn11a ptpn11a cpt1b cpt1b cpt1aa cpt1aa prkaa1 prkaa1 prkaa2 prkaa2 acacb acacb acsbg1 acsbg1 adipoqa adipoqa g6pca.2 g6pca.2 nfkbie nfkbie pomcb pomcb stat3 stat3 socs3b socs3b mapk9 mapk9 tnfrsf1b tnfrsf1b jak2b jak2b mtor mtor pparaa pparaa acsbg2 acsbg2 acsl1b acsl1b nfkbiaa nfkbiaa irs4a irs4a lepa lepa akt3b akt3b acsl3b acsl3b lepb lepb adipor1a adipor1a prkag3b prkag3b agrp agrp g6pca.1 g6pca.1 slc2a1b slc2a1b ikbkb ikbkb prkag2b prkag2b acsl5 acsl5 cpt1cb cpt1cb prkag2a prkag2a rxrba rxrba cpt1ab cpt1ab pparab pparab acsl3a acsl3a g6pcb g6pcb akt1 akt1 adipor2 adipor2 jak2a jak2a rela rela mapk10 mapk10 nfkb1 nfkb1 irs2b irs2b akt3a akt3a akt2l akt2l adipoqb adipoqb traf2b traf2b mapk8a mapk8a Acsl6 Acsl6
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rxrgbRetinoic acid receptor RXR-gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity). (452 aa)
pck2Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (636 aa)
acsl4aAcyl-CoA synthetase long chain family member 4a. (706 aa)
tnfrsf1aTumor necrosis factor receptor superfamily, member 1a. (389 aa)
mapk8bMitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. (384 aa)
chukInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa)
acsl4bAcyl-CoA synthetase long chain family member 4b. (671 aa)
nfkbiabNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (312 aa)
prkag1Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (330 aa)
LOC100334818MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (484 aa)
pck1Phosphoenolpyruvate carboxykinase 1 (soluble). (630 aa)
slc2a1aFacilitated glucose transporter 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (488 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
tnfaTumor necrosis factor a (TNF superfamily, member 2). (234 aa)
ikbkgInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (586 aa)
g6pc3Glucose-6-phosphatase 3; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity); Belongs to the glucose-6-phosphatase family. (339 aa)
socs3aSuppressor of cytokine-signaling 3a. (207 aa)
acsl1aAcyl-CoA synthetase long chain family member 1a. (697 aa)
prkab1bProtein kinase, AMP-activated, beta 1 non-catalytic subunit, b. (260 aa)
traf2aTNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (575 aa)
prkcqProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (713 aa)
ptpn11bTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (592 aa)
cd36CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (465 aa)
traddTumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd. (293 aa)
npyC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (96 aa)
acsl2Acyl-CoA synthetase long chain family member 2. (685 aa)
irs2aInsulin receptor substrate 2a. (1032 aa)
adipor1bAdiponectin receptor 1b. (329 aa)
pomcaPro-opiomelanocortin protein. (222 aa)
prkab1aProtein kinase, AMP-activated, beta 1 non-catalytic subunit, a. (268 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
irs1Insulin receptor substrate 1. (1099 aa)
leprLeptin receptor. (1065 aa)
rxraaRetinoic acid receptor RXR-alpha-A; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription. The high affinity ligand for rxrs is 9-cis retinoic acid. In the absence of ligand, the rar/rxr heterodimer [...] (458 aa)
ptpn11aTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
cpt1bCarnitine palmitoyltransferase 1B (muscle). (770 aa)
cpt1aaCarnitine palmitoyltransferase 1Aa (liver); Belongs to the carnitine/choline acetyltransferase family. (774 aa)
prkaa1Non-specific serine/threonine protein kinase. (573 aa)
prkaa2Non-specific serine/threonine protein kinase. (553 aa)
acacbAcetyl-CoA carboxylase beta. (2386 aa)
acsbg1Acyl-CoA synthetase bubblegum family member 1. (674 aa)
adipoqaAdiponectin, C1Q and collagen domain-containing, a. (263 aa)
g6pca.2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
nfkbieNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon. (343 aa)
pomcbProopiomelanocortin b. (215 aa)
stat3Signal transducer and activator of transcription. (806 aa)
socs3bSuppressor of cytokine-signaling 3b. (210 aa)
mapk9Mitogen-activated protein kinase. (421 aa)
tnfrsf1bTumor necrosis factor receptor superfamily, member 1B. (425 aa)
jak2bTyrosine-protein kinase. (1126 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
pparaaPeroxisome proliferator-activated receptor alpha a. (470 aa)
acsbg2Acyl-CoA synthetase bubblegum family member 2. (794 aa)
acsl1bAcyl-CoA synthetase long chain family member 1b. (697 aa)
nfkbiaaNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (310 aa)
irs4aInsulin receptor substrate 4a. (1051 aa)
lepaPutative leptin. (166 aa)
akt3bNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
acsl3bAcyl-CoA synthetase long chain family member 3b. (711 aa)
lepbLeptin b. (119 aa)
adipor1aAdiponectin receptor 1a. (375 aa)
prkag3bProtein kinase, AMP-activated, gamma 3b non-catalytic subunit. (342 aa)
agrpAgouti-related neuropeptide. (126 aa)
g6pca.1Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (352 aa)
slc2a1bSolute carrier family 2 member 1b; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (489 aa)
ikbkbInhibitor of nuclear factor kappa B kinase subunit beta. (779 aa)
prkag2bProtein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (533 aa)
acsl5Acyl-CoA synthetase long chain family member 5. (681 aa)
cpt1cbCarnitine palmitoyltransferase 1Cb; Belongs to the carnitine/choline acetyltransferase family. (780 aa)
prkag2aProtein kinase, AMP-activated, gamma 2 non-catalytic subunit a. (330 aa)
rxrbaRetinoic acid receptor RXR-beta-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity); Belongs to the nuclear hormone receptor family. NR2 subfamily. (471 aa)
cpt1abCarnitine palmitoyltransferase 1Ab (liver); Belongs to the carnitine/choline acetyltransferase family. (774 aa)
pparabPeroxisome proliferator-activated receptor alpha b. (459 aa)
acsl3aAcyl-CoA synthetase long chain family member 3a. (713 aa)
g6pcbGlucose-6-phosphatase b, catalytic subunit. (363 aa)
akt1Non-specific serine/threonine protein kinase. (247 aa)
adipor2Novel protein similar to vertebrate adiponectin receptor 2 (ADIPOR2). (358 aa)
jak2aTyrosine-protein kinase. (1095 aa)
relaV-rel avian reticuloendotheliosis viral oncogene homolog A. (455 aa)
mapk10Mitogen-activated protein kinase. (472 aa)
nfkb1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (540 aa)
irs2bInsulin receptor substrate 2b. (1062 aa)
akt3aNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
akt2lV-akt murine thymoma viral oncogene homolog 2,-like. (478 aa)
adipoqbAdiponectin, C1Q and collagen domain-containing, b. (299 aa)
traf2bTNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
mapk8aMitogen-activated protein kinase. (427 aa)
Acsl6AMP-binding domain-containing protein. (198 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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