(56 nodes) ERAD pathway, and Domain present in ubiquitin-regulatory proteins network (Esox lucius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105014174	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (244 aa)
	ubac2	UBA domain containing 2. (376 aa)
	LOC105006106	Uncharacterized protein; Belongs to the AAA ATPase family. (806 aa)
	LOC105029882	AUP1 lipid droplet regulating VLDL assembly factor. (422 aa)
	cptp	UBX domain protein 10. (287 aa)
	UBXN4	UBX domain protein 4. (517 aa)
	AMFR	Autocrine motility factor receptor b. (632 aa)
	ubxn7	UBX domain protein 7. (541 aa)
	sel1l3	Uncharacterized protein. (1134 aa)
	sel1l	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (803 aa)
	faf1	Fas (TNFRSF6) associated factor 1. (664 aa)
	ngly1	N-glycanase 1. (645 aa)
	LOC105010167	RING-CH-type domain-containing protein. (916 aa)
	atxn3	Ataxin 3. (348 aa)
	yod1	YOD1 deubiquitinase. (387 aa)
	nsfl1c	NSFL1 (p97) cofactor (p47). (376 aa)
	hm13	Histocompatibility (minor) 13. (426 aa)
	ube2g2	Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (205 aa)
	lrp2bp	LRP2 binding protein. (349 aa)
	LOC105023562	Si:dkey-24p1.6. (817 aa)
	ube4b	Ubiquitination factor E4B, UFD2 homolog (S. cerevisiae). (1384 aa)
	ubxn2a	UBX domain protein 2A. (250 aa)
	LOC105024238	Membrane-associated ring finger (C3HC4) 6. (904 aa)
	ENSELUP00000014517	Zgc:136908; Belongs to the AAA ATPase family. (766 aa)
	ube4a	Ubiquitination factor E4A (UFD2 homolog, yeast). (1075 aa)
	LOC105030866	Zgc:153738. (750 aa)
	plaa	Phospholipase A2-activating protein. (798 aa)
	ubxn6	UBX domain protein 6. (439 aa)
	ubl7	Ubiquitin-like 7b (bone marrow stromal cell-derived). (390 aa)
	ENSELUP00000017572	Autocrine motility factor receptor a. (479 aa)
	rnf139	Ring finger protein 139. (669 aa)
	ubxn8	UBX domain-containing protein. (277 aa)
	ENSELUP00000018960	UBA domain-containing protein. (215 aa)
	faf2	Fas associated factor family member 2. (445 aa)
	ubxn11	UBX domain protein 11. (499 aa)
	svip	Si:ch73-147o17.1. (80 aa)
	syvn1	Synovial apoptosis inhibitor 1, synoviolin. (623 aa)
	LOC105020003	AAA domain-containing protein. (757 aa)
	rnf145	Ring finger protein 145b. (754 aa)
	derl1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (252 aa)
	spata5l1	Spermatogenesis associated 5-like 1. (777 aa)
	chfr	Checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase. (682 aa)
	ubxn1	UBX domain protein 1. (342 aa)
	vcpkmt	Valosin containing protein lysine (K) methyltransferase. (225 aa)
	ufd1	Ubiquitin fusion degradation protein 1 homolog. (309 aa)
	Nploc4	NPL4 homolog, ubiquitin recognition factor. (594 aa)
	erlec1	Endoplasmic reticulum lectin 1. (498 aa)
	LOC105025565	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	LOC105031458	Ubiquilin 4. (590 aa)
	derl2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (254 aa)
	katnal2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (536 aa)
	os9	OS9 endoplasmic reticulum lectin. (665 aa)
	ENSELUP00000038484	ASPSCR1 tether for SLC2A4, UBX domain containing. (472 aa)
	Fignl1	Uncharacterized protein. (184 aa)
	SPATA5	Spermatogenesis associated 5. (935 aa)
	LOC105015884	Zmp:0000000662. (840 aa)

Your Current Organism:

Esox lucius

NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMFR	ENSELUP00000014517	ENSELUP00000004246	ENSELUP00000014517	Autocrine motility factor receptor b.	Zgc:136908; Belongs to the AAA ATPase family.	0.766
AMFR	ENSELUP00000018960	ENSELUP00000004246	ENSELUP00000018960	Autocrine motility factor receptor b.	UBA domain-containing protein.	0.460
AMFR	Fignl1	ENSELUP00000004246	ENSELUP00000039498	Autocrine motility factor receptor b.	Uncharacterized protein.	0.456
AMFR	LOC105006106	ENSELUP00000004246	ENSELUP00000000987	Autocrine motility factor receptor b.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.766
AMFR	LOC105010167	ENSELUP00000004246	ENSELUP00000008391	Autocrine motility factor receptor b.	RING-CH-type domain-containing protein.	0.635
AMFR	LOC105014174	ENSELUP00000004246	ENSELUP00000000302	Autocrine motility factor receptor b.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.889
AMFR	LOC105020003	ENSELUP00000004246	ENSELUP00000023343	Autocrine motility factor receptor b.	AAA domain-containing protein.	0.456
AMFR	LOC105023562	ENSELUP00000004246	ENSELUP00000012629	Autocrine motility factor receptor b.	Si:dkey-24p1.6.	0.839
AMFR	LOC105024238	ENSELUP00000004246	ENSELUP00000013893	Autocrine motility factor receptor b.	Membrane-associated ring finger (C3HC4) 6.	0.635
AMFR	LOC105025565	ENSELUP00000004246	ENSELUP00000033218	Autocrine motility factor receptor b.	Valosin containing protein; Belongs to the AAA ATPase family.	0.766
AMFR	LOC105029882	ENSELUP00000004246	ENSELUP00000002963	Autocrine motility factor receptor b.	AUP1 lipid droplet regulating VLDL assembly factor.	0.524
AMFR	LOC105030866	ENSELUP00000004246	ENSELUP00000015096	Autocrine motility factor receptor b.	Zgc:153738.	0.456
AMFR	LOC105031458	ENSELUP00000004246	ENSELUP00000033787	Autocrine motility factor receptor b.	Ubiquilin 4.	0.460
AMFR	Nploc4	ENSELUP00000004246	ENSELUP00000032698	Autocrine motility factor receptor b.	NPL4 homolog, ubiquitin recognition factor.	0.551
AMFR	SPATA5	ENSELUP00000004246	ENSELUP00000041432	Autocrine motility factor receptor b.	Spermatogenesis associated 5.	0.766
AMFR	derl1	ENSELUP00000004246	ENSELUP00000024313	Autocrine motility factor receptor b.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.954
AMFR	derl2	ENSELUP00000004246	ENSELUP00000034470	Autocrine motility factor receptor b.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.889
AMFR	erlec1	ENSELUP00000004246	ENSELUP00000033021	Autocrine motility factor receptor b.	Endoplasmic reticulum lectin 1.	0.888
AMFR	faf1	ENSELUP00000004246	ENSELUP00000007307	Autocrine motility factor receptor b.	Fas (TNFRSF6) associated factor 1.	0.551
AMFR	faf2	ENSELUP00000004246	ENSELUP00000020533	Autocrine motility factor receptor b.	Fas associated factor family member 2.	0.627