(19 nodes) Cellular response to vascular endothelial growth factor stimulus network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	ENSFHEP00000003609	Growth arrest-specific 1a. (259 aa)
	ccbe1	Collagen and calcium binding EGF domains 1. (397 aa)
	gab1	GRB2-associated binding protein 1. (872 aa)
	LOC105940119	Neuropilin; Belongs to the neuropilin family. (939 aa)
	ENSFHEP00000009221	Uncharacterized protein. (268 aa)
	itgb1bp1	Integrin beta-1-binding protein 1. (288 aa)
	vegfb	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (256 aa)
	flt1	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1273 aa)
	pgf	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (136 aa)
	LOC105928007	Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (202 aa)
	ENSFHEP00000017921	Growth arrest-specific 1b. (243 aa)
	mapkapk2	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily. (403 aa)
	xbp1	X-box binding protein 1. (312 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	LOC105915295	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (203 aa)
	LOC105928008	Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (202 aa)
	nrp1	Neuropilin; Belongs to the neuropilin family. (924 aa)
	LOC105932547	Sprouty RTK signaling antagonist 2. (347 aa)
	ENSFHEP00000033800	PH domain-containing protein. (365 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000003609	ENSFHEP00000009221	ENSFHEP00000003609	ENSFHEP00000009221	Growth arrest-specific 1a.	Uncharacterized protein.	0.950
ENSFHEP00000003609	ENSFHEP00000017921	ENSFHEP00000003609	ENSFHEP00000017921	Growth arrest-specific 1a.	Growth arrest-specific 1b.	0.908
ENSFHEP00000009221	ENSFHEP00000003609	ENSFHEP00000009221	ENSFHEP00000003609	Uncharacterized protein.	Growth arrest-specific 1a.	0.950
ENSFHEP00000009221	ENSFHEP00000017921	ENSFHEP00000009221	ENSFHEP00000017921	Uncharacterized protein.	Growth arrest-specific 1b.	0.905
ENSFHEP00000017921	ENSFHEP00000003609	ENSFHEP00000017921	ENSFHEP00000003609	Growth arrest-specific 1b.	Growth arrest-specific 1a.	0.908
ENSFHEP00000017921	ENSFHEP00000009221	ENSFHEP00000017921	ENSFHEP00000009221	Growth arrest-specific 1b.	Uncharacterized protein.	0.905
ENSFHEP00000033800	flt1	ENSFHEP00000033800	ENSFHEP00000014928	PH domain-containing protein.	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.556
LOC105915295	LOC105928008	ENSFHEP00000029059	ENSFHEP00000031937	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family.	0.905
LOC105915295	mapkapk2	ENSFHEP00000029059	ENSFHEP00000019691	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family.	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.	0.991
LOC105928007	mapkapk2	ENSFHEP00000016442	ENSFHEP00000019691	Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family.	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.	0.986
LOC105928008	LOC105915295	ENSFHEP00000031937	ENSFHEP00000029059	Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family.	0.905
LOC105928008	mapkapk2	ENSFHEP00000031937	ENSFHEP00000019691	Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family.	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.	0.986
LOC105940119	flt1	ENSFHEP00000007820	ENSFHEP00000014928	Neuropilin; Belongs to the neuropilin family.	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.694
LOC105940119	nrp1	ENSFHEP00000007820	ENSFHEP00000032633	Neuropilin; Belongs to the neuropilin family.	Neuropilin; Belongs to the neuropilin family.	0.577
LOC105940119	pgf	ENSFHEP00000007820	ENSFHEP00000015131	Neuropilin; Belongs to the neuropilin family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.628
LOC105940119	vegfa	ENSFHEP00000007820	ENSFHEP00000026266	Neuropilin; Belongs to the neuropilin family.	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	0.610
LOC105940119	vegfb	ENSFHEP00000007820	ENSFHEP00000013275	Neuropilin; Belongs to the neuropilin family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.580
flt1	ENSFHEP00000033800	ENSFHEP00000014928	ENSFHEP00000033800	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	PH domain-containing protein.	0.556
flt1	LOC105940119	ENSFHEP00000014928	ENSFHEP00000007820	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Neuropilin; Belongs to the neuropilin family.	0.694
flt1	gab1	ENSFHEP00000014928	ENSFHEP00000006359	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	GRB2-associated binding protein 1.	0.556