(18 nodes) AKT phosphorylates targets in the nucleus, and rDNA heterochromatin network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	setd7	SET domain containing 7, histone lysine methyltransferase. (363 aa)
	sgk2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (387 aa)
	sirt1	Sirtuin 1. (677 aa)
	LOC103474746	Fork-head domain-containing protein. (389 aa)
	LOC103477833	Forkhead box O6 a. (721 aa)
	foxo3	Forkhead box O3b. (644 aa)
	LOC103474789	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	prmt1	Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (383 aa)
	LOC103476681	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC103471660	Forkhead box O4. (623 aa)
	LOC103473069	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (422 aa)
	SGK1	Non-specific serine/threonine protein kinase. (623 aa)
	LOC103471967	Forkhead box O6 b. (743 aa)
	LOC103475003	Forkhead box O1 a. (664 aa)
	LOC103458349	Fork-head domain-containing protein. (604 aa)
	LOC103478672	Uncharacterized protein; Belongs to the protein kinase superfamily. (366 aa)
	LOC103470003	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	foxo1	Fork-head domain-containing protein. (638 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103458349	LOC103470003	ENSPREP00000024684	ENSPREP00000030956	Fork-head domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.971
LOC103458349	LOC103471967	ENSPREP00000024684	ENSPREP00000020462	Fork-head domain-containing protein.	Forkhead box O6 b.	0.905
LOC103458349	LOC103473069	ENSPREP00000024684	ENSPREP00000014458	Fork-head domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.757
LOC103458349	LOC103474746	ENSPREP00000024684	ENSPREP00000006009	Fork-head domain-containing protein.	Fork-head domain-containing protein.	0.435
LOC103458349	LOC103474789	ENSPREP00000024684	ENSPREP00000008269	Fork-head domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.971
LOC103458349	LOC103476681	ENSPREP00000024684	ENSPREP00000012589	Fork-head domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.971
LOC103458349	LOC103478672	ENSPREP00000024684	ENSPREP00000026869	Fork-head domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.736
LOC103458349	SGK1	ENSPREP00000024684	ENSPREP00000016570	Fork-head domain-containing protein.	Non-specific serine/threonine protein kinase.	0.757
LOC103458349	foxo3	ENSPREP00000024684	ENSPREP00000007444	Fork-head domain-containing protein.	Forkhead box O3b.	0.902
LOC103458349	prmt1	ENSPREP00000024684	ENSPREP00000009284	Fork-head domain-containing protein.	Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.913
LOC103458349	setd7	ENSPREP00000024684	ENSPREP00000001051	Fork-head domain-containing protein.	SET domain containing 7, histone lysine methyltransferase.	0.908
LOC103458349	sgk2	ENSPREP00000024684	ENSPREP00000001264	Fork-head domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.757
LOC103458349	sirt1	ENSPREP00000024684	ENSPREP00000003960	Fork-head domain-containing protein.	Sirtuin 1.	0.986
LOC103470003	LOC103458349	ENSPREP00000030956	ENSPREP00000024684	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.971
LOC103470003	LOC103471660	ENSPREP00000030956	ENSPREP00000012847	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O4.	0.901
LOC103470003	LOC103471967	ENSPREP00000030956	ENSPREP00000020462	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O6 b.	0.933
LOC103470003	LOC103473069	ENSPREP00000030956	ENSPREP00000014458	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.571
LOC103470003	LOC103474746	ENSPREP00000030956	ENSPREP00000006009	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.400
LOC103470003	LOC103474789	ENSPREP00000030956	ENSPREP00000008269	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.400
LOC103470003	LOC103475003	ENSPREP00000030956	ENSPREP00000020928	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O1 a.	0.971