(21 nodes) Nicotinate and nicotinamide metabolism network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (311 aa)
	QPRT	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (296 aa)
	nadk2	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. (433 aa)
	LOC103462093	Muscle-specific beta 1 integrin binding protein 2. (206 aa)
	LOC103462087	Nicotinamide nucleotide transhydrogenase 2. (1014 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (385 aa)
	naprt	Nicotinate phosphoribosyltransferase. (608 aa)
	LOC103473658	Nicotinamide nucleotide transhydrogenase. (1096 aa)
	sirt5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (326 aa)
	nadk	NAD kinase a. (361 aa)
	nampt	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (505 aa)
	LOC103479788	Nicotinamide riboside kinase 2. (202 aa)
	LOC103479795	NAD kinase b. (491 aa)
	LOC103479319	Nicotinamide-nucleotide adenylyltransferase. (265 aa)
	LOC103470104	Nicotinamide riboside kinase 1. (224 aa)
	nmnat1	Nicotinamide-nucleotide adenylyltransferase. (285 aa)
	LOC103466083	Si:dkey-103i16.6. (445 aa)
	LOC103464095	Uncharacterized protein. (197 aa)
	LOC103479463	Sirtuin 6. (339 aa)
	nmnat2	Nicotinamide nucleotide adenylyltransferase 2. (307 aa)
	LOC103465472	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (494 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103462087	LOC103466083	ENSPREP00000012612	ENSPREP00000025749	Nicotinamide nucleotide transhydrogenase 2.	Si:dkey-103i16.6.	0.902
LOC103462087	LOC103473658	ENSPREP00000012612	ENSPREP00000014070	Nicotinamide nucleotide transhydrogenase 2.	Nicotinamide nucleotide transhydrogenase.	0.901
LOC103462087	LOC103479319	ENSPREP00000012612	ENSPREP00000020926	Nicotinamide nucleotide transhydrogenase 2.	Nicotinamide-nucleotide adenylyltransferase.	0.910
LOC103462087	LOC103479463	ENSPREP00000012612	ENSPREP00000026036	Nicotinamide nucleotide transhydrogenase 2.	Sirtuin 6.	0.901
LOC103462087	LOC103479795	ENSPREP00000012612	ENSPREP00000020208	Nicotinamide nucleotide transhydrogenase 2.	NAD kinase b.	0.934
LOC103462087	nadk	ENSPREP00000012612	ENSPREP00000015673	Nicotinamide nucleotide transhydrogenase 2.	NAD kinase a.	0.934
LOC103462087	nadk2	ENSPREP00000012612	ENSPREP00000010415	Nicotinamide nucleotide transhydrogenase 2.	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	0.926
LOC103462087	nmnat1	ENSPREP00000012612	ENSPREP00000023066	Nicotinamide nucleotide transhydrogenase 2.	Nicotinamide-nucleotide adenylyltransferase.	0.910
LOC103462087	nmnat2	ENSPREP00000012612	ENSPREP00000028650	Nicotinamide nucleotide transhydrogenase 2.	Nicotinamide nucleotide adenylyltransferase 2.	0.908
LOC103462087	sirt2	ENSPREP00000012612	ENSPREP00000012959	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.900
LOC103462087	sirt4	ENSPREP00000012612	ENSPREP00000003147	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.900
LOC103462087	sirt5	ENSPREP00000012612	ENSPREP00000014162	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.901
LOC103462093	LOC103465472	ENSPREP00000012341	ENSPREP00000030128	Muscle-specific beta 1 integrin binding protein 2.	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.	0.915
LOC103462093	LOC103479319	ENSPREP00000012341	ENSPREP00000020926	Muscle-specific beta 1 integrin binding protein 2.	Nicotinamide-nucleotide adenylyltransferase.	0.933
LOC103462093	QPRT	ENSPREP00000012341	ENSPREP00000005046	Muscle-specific beta 1 integrin binding protein 2.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.924
LOC103462093	nampt	ENSPREP00000012341	ENSPREP00000017169	Muscle-specific beta 1 integrin binding protein 2.	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.	0.920
LOC103462093	naprt	ENSPREP00000012341	ENSPREP00000013654	Muscle-specific beta 1 integrin binding protein 2.	Nicotinate phosphoribosyltransferase.	0.938
LOC103462093	nmnat1	ENSPREP00000012341	ENSPREP00000023066	Muscle-specific beta 1 integrin binding protein 2.	Nicotinamide-nucleotide adenylyltransferase.	0.933
LOC103462093	nmnat2	ENSPREP00000012341	ENSPREP00000028650	Muscle-specific beta 1 integrin binding protein 2.	Nicotinamide nucleotide adenylyltransferase 2.	0.932
LOC103464095	LOC103465472	ENSPREP00000025979	ENSPREP00000030128	Uncharacterized protein.	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.	0.915