STRINGSTRING
pcna pcna rad51 rad51 H2MVD7_ORYLA H2MVD7_ORYLA rfc2 rfc2 exd2 exd2 Rad51c Rad51c rfc4 rfc4 Atm Atm ankrd12 ankrd12 blm blm ENSORLP00000027619 ENSORLP00000027619 rcbtb2 rcbtb2 meiob meiob RPA1 RPA1 rfc3 rfc3 brca1 brca1 rpa1 rpa1 rmi2 rmi2 rmi1 rmi1 LOC101165789 LOC101165789 ankrd11 ankrd11 chek1 chek1 polh polh mre11 mre11 POLE POLE uba52 uba52 polk polk dna2 dna2 kxd1 kxd1 pold1 pold1 RCBTB1 RCBTB1 H2M970_ORYLA H2M970_ORYLA ubc ubc pold2 pold2 pole2 pole2 top3a top3a rpa2 rpa2 eme1 eme1 rad51d rad51d pole4 pole4 SPIDR SPIDR pold3 pold3 exo1 exo1 pole3 pole3 xrcc2 xrcc2 ENSORLP00000044710 ENSORLP00000044710 rfc1 rfc1 palb2 palb2 gen1 gen1 Rbbp8 Rbbp8 LOC101160001 LOC101160001 slx4 slx4 brca2 brca2 rpa3 rpa3 rps27a rps27a EME2 EME2 pold4 pold4 recql4 recql4 ENSORLP00000030959 ENSORLP00000030959 rad51ap1 rad51ap1 ENSORLP00000032044 ENSORLP00000032044 ENSORLP00000033513 ENSORLP00000033513 tdrd3 tdrd3 rfc5 rfc5 kat5 kat5 mus81 mus81 ENSORLP00000036824 ENSORLP00000036824 LOC101173980 LOC101173980 rad50 rad50
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (298 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (396 aa)
H2MVD7_ORYLADNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (308 aa)
rfc2Replication factor C (activator 1) 2. (355 aa)
exd2Exonuclease 3'-5' domain containing 2. (623 aa)
Rad51cRAD51 paralog C. (307 aa)
rfc4Replication factor C (activator 1) 4. (355 aa)
AtmUncharacterized protein. (147 aa)
ankrd12Ankyrin repeat domain 12. (1906 aa)
blmUncharacterized protein. (1393 aa)
ENSORLP00000027619TAN domain-containing protein. (321 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
meiobMethionine sulfoxide reductase B1b. (462 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (655 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
brca1Uncharacterized protein. (1292 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (598 aa)
rmi2RecQ mediated genome instability 2. (140 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (648 aa)
LOC101165789Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (589 aa)
ankrd11Ankyrin repeat domain 11. (2833 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (454 aa)
polhPolymerase (DNA directed), eta. (708 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (694 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1100 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
polkPolymerase (DNA directed) kappa. (871 aa)
dna2DNA replication helicase/nuclease 2. (1396 aa)
kxd1KxDL motif containing 1. (184 aa)
pold1DNA polymerase. (1107 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
H2M970_ORYLAUbiquitin-like domain-containing protein. (129 aa)
ubcUbiquitin B. (782 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (524 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1034 aa)
rpa2Replication protein A2. (280 aa)
eme1Essential meiotic structure-specific endonuclease 1. (459 aa)
rad51dRAD51 paralog D. (332 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (124 aa)
SPIDRScaffold protein involved in DNA repair. (885 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (441 aa)
exo1Exonuclease 1. (749 aa)
pole3CBFD_NFYB_HMF domain-containing protein. (148 aa)
xrcc2X-ray repair cross complementing 2. (313 aa)
ENSORLP00000044710annotation not available (829 aa)
rfc1Replication factor C subunit 1. (1152 aa)
palb2PALB2_WD40 domain-containing protein. (1311 aa)
gen1Uncharacterized protein. (876 aa)
Rbbp8SAE2 domain-containing protein. (78 aa)
LOC101160001ANK_REP_REGION domain-containing protein. (658 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1590 aa)
brca2BRCA2 DNA repair associated. (3161 aa)
rpa3Replication protein A3. (122 aa)
rps27aRibosomal protein S27a. (195 aa)
EME2ERCC4 domain-containing protein. (443 aa)
pold4Si:dkey-28b4.7. (108 aa)
recql4RecQ helicase-like 4. (1546 aa)
ENSORLP00000030959Uncharacterized protein. (229 aa)
rad51ap1RAD51 associated protein 1. (315 aa)
ENSORLP00000032044Reverse transcriptase domain-containing protein. (488 aa)
ENSORLP00000033513DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (398 aa)
tdrd3Tudor domain containing 3. (799 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (580 aa)
mus81MUS81 structure-specific endonuclease subunit. (656 aa)
ENSORLP00000036824Uncharacterized protein. (311 aa)
LOC101173980Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (269 aa)
rad50RAD50 homolog, double strand break repair protein. (1311 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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