(36 nodes) Stem cell population maintenance network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	smc3	Structural maintenance of chromosomes protein. (1223 aa)
	ctr9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1174 aa)
	mettl14	Methyltransferase like 14; Belongs to the MT-A70-like family. (460 aa)
	I3JEI7_ORENI	Nanos homolog 2; Belongs to the nanos family. (166 aa)
	Hesx1	Homeobox domain-containing protein. (138 aa)
	fezf2	FEZ family zinc finger 2. (425 aa)
	rtf1	RTF1 homolog, Paf1/RNA polymerase II complex component. (671 aa)
	piwil2	Piwi-like RNA-mediated gene silencing 2; Belongs to the argonaute family. (1072 aa)
	ENSONIP00000054390	annotation not available (96 aa)
	cdc73	Ro60, Y RNA binding protein. (530 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
	LOC100693372	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. (951 aa)
	med14	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1431 aa)
	Mcph1	Microcephalin 1. (734 aa)
	ENSONIP00000035341	T-cell acute lymphocytic leukemia protein 1 homolog. (100 aa)
	LOC109194259	T-cell acute lymphocytic leukemia 1. (447 aa)
	ENSONIP00000032312	annotation not available (279 aa)
	rif1	Replication timing regulatory factor 1. (2388 aa)
	LOC100706531	Failed axon connections homolog, metaxin like GST domain containing a. (410 aa)
	fancd2	FA complementation group D2. (1457 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
	LOC100707945	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
	sall4	Spalt-like transcription factor 4. (1082 aa)
	LOC100692547	Lin-28 homolog A. (202 aa)
	trim8	Tripartite motif containing 8b. (594 aa)
	fancc	FA complementation group C. (583 aa)
	prdm14	PR domain containing 14. (601 aa)
	lig4	DNA ligase. (910 aa)
	lsm1	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (133 aa)
	pcm1	Pericentriolar material 1. (2120 aa)
	LOC100710124	RING-type domain-containing protein. (566 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (594 aa)
	faxc	Failed axon connections homolog, metaxin like GST domain containing b. (415 aa)
	vps72	Vacuolar protein sorting 72 homolog a. (366 aa)
	dis3l2	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (1042 aa)
	EIF4ENIF1	Eukaryotic translation initiation factor 4E nuclear import factor 1. (953 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	LOC100693372	ENSONIP00000046788	ENSONIP00000044451	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins.	0.901
EIF4ENIF1	cdc73	ENSONIP00000074693	ENSONIP00000047370	Eukaryotic translation initiation factor 4E nuclear import factor 1.	Ro60, Y RNA binding protein.	0.416
EIF4ENIF1	lsm1	ENSONIP00000074693	ENSONIP00000013555	Eukaryotic translation initiation factor 4E nuclear import factor 1.	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	0.454
EIF4ENIF1	rtf1	ENSONIP00000074693	ENSONIP00000060804	Eukaryotic translation initiation factor 4E nuclear import factor 1.	RTF1 homolog, Paf1/RNA polymerase II complex component.	0.551
EIF4ENIF1	vps72	ENSONIP00000074693	ENSONIP00000003475	Eukaryotic translation initiation factor 4E nuclear import factor 1.	Vacuolar protein sorting 72 homolog a.	0.466
ENSONIP00000054390	fancd2	ENSONIP00000054390	ENSONIP00000023917	annotation not available	FA complementation group D2.	0.645
I3JEI7_ORENI	piwil2	ENSONIP00000007278	ENSONIP00000057047	Nanos homolog 2; Belongs to the nanos family.	Piwi-like RNA-mediated gene silencing 2; Belongs to the argonaute family.	0.693
I3JEI7_ORENI	sall4	ENSONIP00000007278	ENSONIP00000020852	Nanos homolog 2; Belongs to the nanos family.	Spalt-like transcription factor 4.	0.502
LOC100692547	dis3l2	ENSONIP00000020405	ENSONIP00000076718	Lin-28 homolog A.	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily.	0.494
LOC100692547	prdm14	ENSONIP00000020405	ENSONIP00000017914	Lin-28 homolog A.	PR domain containing 14.	0.640
LOC100692547	sall4	ENSONIP00000020405	ENSONIP00000020852	Lin-28 homolog A.	Spalt-like transcription factor 4.	0.630
LOC100693372	CDH2	ENSONIP00000044451	ENSONIP00000046788	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins.	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.901
Mcph1	fancd2	ENSONIP00000036318	ENSONIP00000023917	Microcephalin 1.	FA complementation group D2.	0.645
cdc73	EIF4ENIF1	ENSONIP00000047370	ENSONIP00000074693	Ro60, Y RNA binding protein.	Eukaryotic translation initiation factor 4E nuclear import factor 1.	0.416
cdc73	ctr9	ENSONIP00000047370	ENSONIP00000064063	Ro60, Y RNA binding protein.	CTR9 homolog, Paf1/RNA polymerase II complex component.	0.999
cdc73	rtf1	ENSONIP00000047370	ENSONIP00000060804	Ro60, Y RNA binding protein.	RTF1 homolog, Paf1/RNA polymerase II complex component.	0.997
cdc73	vps72	ENSONIP00000047370	ENSONIP00000003475	Ro60, Y RNA binding protein.	Vacuolar protein sorting 72 homolog a.	0.566
ctr9	cdc73	ENSONIP00000064063	ENSONIP00000047370	CTR9 homolog, Paf1/RNA polymerase II complex component.	Ro60, Y RNA binding protein.	0.999
ctr9	lsm1	ENSONIP00000064063	ENSONIP00000013555	CTR9 homolog, Paf1/RNA polymerase II complex component.	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	0.570
ctr9	rtf1	ENSONIP00000064063	ENSONIP00000060804	CTR9 homolog, Paf1/RNA polymerase II complex component.	RTF1 homolog, Paf1/RNA polymerase II complex component.	0.997