(56 nodes) Histone deacetylase complex, and HDACs deacetylate histones network (Haplochromis burtoni)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	LOC102295870	Histone deacetylase 12. (392 aa)
	hdac4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1105 aa)
	sin3b	SIN3 transcription regulator family member B. (1268 aa)
	LOC102298768	Methyl-CpG binding domain protein 3a. (274 aa)
	phf21a	PHD finger protein 21Ab. (835 aa)
	sin3a	SIN3 transcription regulator family member Aa. (1273 aa)
	gatad2b	GATA zinc finger domain containing 2B. (649 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (827 aa)
	ENSHBUP00000007021	Uncharacterized protein. (103 aa)
	rcor3	REST corepressor 3. (555 aa)
	gatad2a	GATA zinc finger domain containing 2Ab. (666 aa)
	LOC102301628	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	hdac8	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (379 aa)
	hdac11	Histone deacetylase 11. (367 aa)
	LOC102313106	BRMS1 like transcriptional repressor b. (380 aa)
	mta2	Metastasis associated 1 family, member 2. (663 aa)
	sap30l	Sap30-like. (178 aa)
	mbd2	MBD domain-containing protein. (266 aa)
	hdac10	Histone deacetylase 10. (726 aa)
	LOC102312028	Uncharacterized protein. (262 aa)
	chd4	Uncharacterized protein. (1812 aa)
	mta1	Metastasis associated 1. (638 aa)
	LOC102313969	BRMS1 transcriptional repressor and anoikis regulator. (255 aa)
	LOC102303803	Transducin (beta)-like 1 X-linked receptor 1b. (512 aa)
	hdac9	Histone deacetylase 9b. (623 aa)
	LOC102291041	Chromodomain helicase DNA binding protein 4a. (1861 aa)
	hdac6	Histone deacetylase 6. (1102 aa)
	hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1140 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (490 aa)
	arid4b	Translocase of outer mitochondrial membrane 20. (1300 aa)
	hmg20a	High mobility group 20A. (291 aa)
	ENSHBUP00000019290	Uncharacterized protein. (890 aa)
	LOC102307082	Uncharacterized protein. (250 aa)
	LOC102297072	GATA zinc finger domain containing 2A. (736 aa)
	mbd4	Methyl-CpG binding domain protein 4. (175 aa)
	ing1	Inhibitor of growth protein. (328 aa)
	LOC102307724	Transducin beta like 1 X-linked. (534 aa)
	LOC102307377	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (951 aa)
	aire	Autoimmune regulator. (499 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (515 aa)
	hmg20b	High mobility group 20B. (299 aa)
	LOC102309746	SIN3 transcription regulator family member Ab. (1293 aa)
	suds3	SDS3 homolog, SIN3A corepressor complex component. (318 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1093 aa)
	chd5	Chromodomain helicase DNA binding protein 5. (1804 aa)
	ENSHBUP00000029451	REST corepressor 1. (447 aa)
	brms1l	Uncharacterized protein. (269 aa)
	rcor2	REST corepressor 2. (540 aa)
	wdr73	WD repeat domain 73. (382 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	LOC102310951	Chromodomain helicase DNA binding protein 3. (2129 aa)
	PHF21B	PHD finger protein 21B. (565 aa)
	ENSHBUP00000033650	MBD domain-containing protein. (177 aa)
	rest	RE1-silencing transcription factor. (972 aa)
	mxd1	MAX dimerization protein 1. (222 aa)
	mta3	Metastasis associated 1 family, member 3. (700 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHBUP00000007021	ENSHBUP00000033650	ENSHBUP00000007021	ENSHBUP00000033650	Uncharacterized protein.	MBD domain-containing protein.	0.429
ENSHBUP00000007021	HDAC1	ENSHBUP00000007021	ENSHBUP00000018206	Uncharacterized protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.724
ENSHBUP00000007021	HDAC3	ENSHBUP00000007021	ENSHBUP00000031980	Uncharacterized protein.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.724
ENSHBUP00000007021	HDAC4	ENSHBUP00000007021	ENSHBUP00000028729	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.596
ENSHBUP00000007021	LOC102295870	ENSHBUP00000007021	ENSHBUP00000001107	Uncharacterized protein.	Histone deacetylase 12.	0.589
ENSHBUP00000007021	LOC102301628	ENSHBUP00000007021	ENSHBUP00000009492	Uncharacterized protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.724
ENSHBUP00000007021	LOC102307377	ENSHBUP00000007021	ENSHBUP00000021289	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.596
ENSHBUP00000007021	LOC102309746	ENSHBUP00000007021	ENSHBUP00000026355	Uncharacterized protein.	SIN3 transcription regulator family member Ab.	0.889
ENSHBUP00000007021	LOC102313106	ENSHBUP00000007021	ENSHBUP00000011401	Uncharacterized protein.	BRMS1 like transcriptional repressor b.	0.494
ENSHBUP00000007021	LOC102313969	ENSHBUP00000007021	ENSHBUP00000015220	Uncharacterized protein.	BRMS1 transcriptional repressor and anoikis regulator.	0.494
ENSHBUP00000007021	arid4b	ENSHBUP00000007021	ENSHBUP00000018280	Uncharacterized protein.	Translocase of outer mitochondrial membrane 20.	0.943
ENSHBUP00000007021	brms1l	ENSHBUP00000007021	ENSHBUP00000030962	Uncharacterized protein.	Uncharacterized protein.	0.494
ENSHBUP00000007021	hdac10	ENSHBUP00000007021	ENSHBUP00000013678	Uncharacterized protein.	Histone deacetylase 10.	0.596
ENSHBUP00000007021	hdac11	ENSHBUP00000007021	ENSHBUP00000011130	Uncharacterized protein.	Histone deacetylase 11.	0.589
ENSHBUP00000007021	hdac4	ENSHBUP00000007021	ENSHBUP00000003723	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.596
ENSHBUP00000007021	hdac5	ENSHBUP00000007021	ENSHBUP00000018132	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.596
ENSHBUP00000007021	hdac6	ENSHBUP00000007021	ENSHBUP00000018061	Uncharacterized protein.	Histone deacetylase 6.	0.596
ENSHBUP00000007021	hdac8	ENSHBUP00000007021	ENSHBUP00000010612	Uncharacterized protein.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.724
ENSHBUP00000007021	hdac9	ENSHBUP00000007021	ENSHBUP00000016247	Uncharacterized protein.	Histone deacetylase 9b.	0.596
ENSHBUP00000007021	ing1	ENSHBUP00000007021	ENSHBUP00000020120	Uncharacterized protein.	Inhibitor of growth protein.	0.547