(135 nodes) Eye morphogenesis network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ahi1.L	Uncharacterized protein. (1124 aa)
	A0A1L8EK96	Uncharacterized protein. (127 aa)
	tbc1d20.1	Rab-GAP TBC domain-containing protein. (387 aa)
	A0A1L8EKH9	STAT_int domain-containing protein. (635 aa)
	A0A1L8ELS9	BHLH domain-containing protein. (214 aa)
	A0A1L8EM18	Uncharacterized protein. (2125 aa)
	sox8	HMG box domain-containing protein. (461 aa)
	Stat3.2.L	Signal transducer and activator of transcription. (760 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	bhlhe23	BHLH domain-containing protein. (214 aa)
	sp3	Uncharacterized protein. (717 aa)
	Sox8.L	HMG box domain-containing protein. (459 aa)
	A0A1L8F0V0	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (650 aa)
	crb2	Uncharacterized protein. (1472 aa)
	Crb2.L	Uncharacterized protein. (1120 aa)
	ttc8	TPR_REGION domain-containing protein. (505 aa)
	Vax1.S	Homeobox domain-containing protein. (295 aa)
	A0A1L8FDX8	Uncharacterized protein. (139 aa)
	A0A1L8FEW4	Phosphodiesterase. (855 aa)
	mfn2	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (756 aa)
	A0A1L8FFY2	Uncharacterized protein. (501 aa)
	Pax10a	Homeobox domain-containing protein. (281 aa)
	Bax.L	Uncharacterized protein. (221 aa)
	G50	Uncharacterized protein. (980 aa)
	Vax1.L	Homeobox domain-containing protein. (287 aa)
	A0A1L8FIG1	Uncharacterized protein. (137 aa)
	A0A1L8FJI6	Phosphodiesterase. (857 aa)
	Cabp4.L	Uncharacterized protein. (410 aa)
	A0A1L8FKN8	Uncharacterized protein. (183 aa)
	mfrp	Uncharacterized protein. (590 aa)
	A0A1L8FLE3	Uncharacterized protein. (501 aa)
	thy1	Ig-like domain-containing protein. (165 aa)
	Epha2.L	Uncharacterized protein. (948 aa)
	Aqp1.S	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (274 aa)
	Deltaef1	Uncharacterized protein. (1089 aa)
	gli3	Uncharacterized protein. (1565 aa)
	Calb1.S	Uncharacterized protein. (316 aa)
	A0A1L8FTV3	Uncharacterized protein. (786 aa)
	Aqp1.L	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (274 aa)
	Zeb1.S	Uncharacterized protein. (919 aa)
	ptf1a	BHLH domain-containing protein. (270 aa)
	gli3-2	Uncharacterized protein. (1568 aa)
	Rp1.L	Uncharacterized protein. (1863 aa)
	Tbc1d20.2.L	Rab-GAP TBC domain-containing protein. (388 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1206 aa)
	vsx1	Uncharacterized protein. (340 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	prdm1	Uncharacterized protein. (780 aa)
	A0A1L8G6P5	Uncharacterized protein. (774 aa)
	Jag1.L	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
	dzank1	ANK_REP_REGION domain-containing protein. (779 aa)
	Vsx1.L	Uncharacterized protein. (344 aa)
	fjx1	Uncharacterized protein. (385 aa)
	A0A1L8GDP9	Uncharacterized protein. (457 aa)
	pax6	Uncharacterized protein. (467 aa)
	A0A1L8GED0	Uncharacterized protein. (988 aa)
	faslg	TNF_2 domain-containing protein. (246 aa)
	Atf4.S	BZIP domain-containing protein. (342 aa)
	A0A1L8GI58	Uncharacterized protein. (933 aa)
	fjx1-2	Uncharacterized protein. (386 aa)
	pax6-2	Uncharacterized protein. (467 aa)
	Th.L	BH4_AAA_HYDROXYL_2 domain-containing protein. (454 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	Rpgrip1l.L	C2 domain-containing protein. (1243 aa)
	Faslg.L	TNF_2 domain-containing protein. (248 aa)
	A0A1L8GN74	Uncharacterized protein. (1390 aa)
	Atf4.L	BZIP domain-containing protein. (343 aa)
	A0A1L8GSA8	Uncharacterized protein. (1053 aa)
	A0A1L8GSF2	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (512 aa)
	A0A1L8GSW8	Uncharacterized protein. (2869 aa)
	stra6	Uncharacterized protein. (639 aa)
	nr2e3	Uncharacterized protein. (404 aa)
	A0A1L8GTC8	TPR_REGION domain-containing protein. (516 aa)
	A0A1L8GTF9	Uncharacterized protein. (645 aa)
	tspan12	Tetraspanin. (296 aa)
	Frs2.S	IRS-type PTB domain-containing protein. (509 aa)
	A0A1L8GY48	BH4_AAA_HYDROXYL_2 domain-containing protein. (487 aa)
	frs2	IRS-type PTB domain-containing protein. (518 aa)
	tspan12-2	Tetraspanin. (304 aa)
	A0A1L8GZU0	Uncharacterized protein. (509 aa)
	stra6-2	Uncharacterized protein. (639 aa)
	Nr2e3.L	Uncharacterized protein. (403 aa)
	A0A1L8H0J8	Uncharacterized protein. (2883 aa)
	A0A1L8H163	Uncharacterized protein. (1053 aa)
	nectin3	Uncharacterized protein. (524 aa)
	phactr4	Phosphatase and actin regulator. (694 aa)
	Nf1.S	Uncharacterized protein. (2774 aa)
	Fat3.S	Uncharacterized protein. (3417 aa)
	A0A1L8HAZ0	Uncharacterized protein. (1286 aa)
	col8a1-2	C1q domain-containing protein. (731 aa)
	phactr4-2	Phosphatase and actin regulator. (709 aa)
	nectin3-2	Uncharacterized protein. (524 aa)
	Alcam.L	Uncharacterized protein. (573 aa)
	nf1	Uncharacterized protein. (2759 aa)
	vax2	Homeobox domain-containing protein. (294 aa)
	kdr	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1326 aa)
	A0A1L8HLB9	Uncharacterized protein. (4670 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	Rorb.S	Uncharacterized protein. (458 aa)
	gas1	Uncharacterized protein. (299 aa)
	ntrk2	Tyrosine-protein kinase receptor. (807 aa)
	agtpbp1	Uncharacterized protein. (1226 aa)
	Rpgrip1.S	C2 domain-containing protein. (1285 aa)
	A0A1L8HRR4	Nipped-B protein. (1728 aa)
	A0A1L8HTZ2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
	A0A1L8HU09	Uncharacterized protein. (1875 aa)
	Tdrd7.L	Uncharacterized protein. (1089 aa)
	agtpbp1-2	Uncharacterized protein. (1225 aa)
	rorb	Uncharacterized protein. (458 aa)
	gas1-2	Uncharacterized protein. (284 aa)
	Ntrk2.S	Tyrosine-protein kinase receptor. (821 aa)
	A0A1L8HZD2	BZIP domain-containing protein. (266 aa)
	Rpgrip1.L	C2 domain-containing protein. (1230 aa)
	foxn4	Fork-head domain-containing protein. (505 aa)
	nipbl	Nipped-B protein. (2844 aa)
	Mfsd2a.S	Uncharacterized protein. (526 aa)
	mfsd2a	LOC100101290 protein. (524 aa)
	foxn4-2	Forkhead box protein FoxN4. (506 aa)
	sp3-2	LOC100037013 protein. (724 aa)
	fgf2-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	vax2-2	Vax2 protein. (302 aa)
	Calb1	Calbindin D28k. (260 aa)
	X-Delta-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (642 aa)
	aldh1a3	RALDH3; Belongs to the aldehyde dehydrogenase family. (512 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	alcam	MGC84135 protein. (570 aa)
	mfn2-2	MGC81251 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (756 aa)
	ctnnb1-2	Ctnnb1-prov protein. (781 aa)
	mfap2	Mfap2-prov protein. (193 aa)
	tbc1d20.1-2	MGC52691 protein. (412 aa)
	dll1-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	Pax10b	Paired box 10b. (281 aa)
	prdm1-2	Uncharacterized protein. (780 aa)
	mfsd2b	Uncharacterized protein. (511 aa)
	ift172	Uncharacterized protein. (1749 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EKH9	A0A1L8FKN8	A0A1L8EKH9	A0A1L8FKN8	STAT_int domain-containing protein.	Uncharacterized protein.	0.498
A0A1L8EKH9	Faslg.L	A0A1L8EKH9	A0A1L8GN18	STAT_int domain-containing protein.	TNF_2 domain-containing protein.	0.436
A0A1L8EKH9	prdm1	A0A1L8EKH9	A0A1L8G300	STAT_int domain-containing protein.	Uncharacterized protein.	0.483
A0A1L8EKH9	prdm1-2	A0A1L8EKH9	A0A1L8G929	STAT_int domain-containing protein.	Uncharacterized protein.	0.483
A0A1L8EM18	gli3	A0A1L8EM18	A0A1L8FRV1	Uncharacterized protein.	Uncharacterized protein.	0.402
A0A1L8EM18	gli3-2	A0A1L8EM18	A0A1L8FWR2	Uncharacterized protein.	Uncharacterized protein.	0.402
A0A1L8FDX8	A0A1L8GSW8	A0A1L8FDX8	A0A1L8GSW8	Uncharacterized protein.	Uncharacterized protein.	0.735
A0A1L8FDX8	A0A1L8H0J8	A0A1L8FDX8	A0A1L8H0J8	Uncharacterized protein.	Uncharacterized protein.	0.735
A0A1L8FDX8	mfap2	A0A1L8FDX8	Q8AVW2	Uncharacterized protein.	Mfap2-prov protein.	0.817
A0A1L8FFY2	ctnnb1	A0A1L8FFY2	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.426
A0A1L8FFY2	ctnnb1-2	A0A1L8FFY2	Q7ZX35	Uncharacterized protein.	Ctnnb1-prov protein.	0.426
A0A1L8FFY2	nectin3	A0A1L8FFY2	A0A1L8H791	Uncharacterized protein.	Uncharacterized protein.	0.909
A0A1L8FFY2	nectin3-2	A0A1L8FFY2	A0A1L8HEG6	Uncharacterized protein.	Uncharacterized protein.	0.909
A0A1L8FIG1	A0A1L8GSW8	A0A1L8FIG1	A0A1L8GSW8	Uncharacterized protein.	Uncharacterized protein.	0.735
A0A1L8FIG1	A0A1L8H0J8	A0A1L8FIG1	A0A1L8H0J8	Uncharacterized protein.	Uncharacterized protein.	0.735
A0A1L8FIG1	mfap2	A0A1L8FIG1	Q8AVW2	Uncharacterized protein.	Mfap2-prov protein.	0.817
A0A1L8FKN8	A0A1L8EKH9	A0A1L8FKN8	A0A1L8EKH9	Uncharacterized protein.	STAT_int domain-containing protein.	0.498
A0A1L8FKN8	Ntrk2.S	A0A1L8FKN8	A0A1L8HZ01	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.536
A0A1L8FKN8	Stat3.2.L	A0A1L8FKN8	A0A1L8ERP4	Uncharacterized protein.	Signal transducer and activator of transcription.	0.586
A0A1L8FKN8	fgf2	A0A1L8FKN8	A0A1L8HLX5	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.549