23 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	git2	MGC80878 protein. (759 aa)
	grb2	Uncharacterized protein. (229 aa)
	itgb4	Integrin beta. (1770 aa)
	itgb4-2	Integrin beta. (1770 aa)
	grb2-2	Uncharacterized protein. (229 aa)
	egfr	Receptor protein-tyrosine kinase. (1208 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	Esr1.S	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	mmut	B12-binding domain-containing protein. (758 aa)
	Cdh3.S	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	arhgef7	Uncharacterized protein. (818 aa)
	PR-2	Uncharacterized protein. (730 aa)
	Git1	Uncharacterized protein. (737 aa)
	arhgef7-2	Uncharacterized protein. (802 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
	Cdk6.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (319 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
	Gapdh.S	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	actl6a	Baf53a-pending-prov protein; Belongs to the actin family. (429 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	pgr	Progesterone receptor. (732 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdh3.S	Esr1.S	A0A1L8GET9	A0A1L8G265	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.563
Cdh3.S	Gapdh.S	A0A1L8GET9	Q7ZY52	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Glyceraldehyde-3-phosphate dehydrogenase.	0.763
Cdh3.S	actl6a	A0A1L8GET9	Q7ZYI5	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Baf53a-pending-prov protein; Belongs to the actin family.	0.931
Cdh3.S	cdh1	A0A1L8GET9	A0A1L8GKV4	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.903
Cdh3.S	cdh3	A0A1L8GET9	A0A1L8GKW6	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.901
Cdh3.S	egfr	A0A1L8GET9	A0A1L8FRS8	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Receptor protein-tyrosine kinase.	0.880
Cdh3.S	egfr-2	A0A1L8GET9	A0A1L8FWP8	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Receptor protein-tyrosine kinase.	0.880
Cdh3.S	esr1	A0A1L8GET9	Q6W5G7	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.563
Cdh3.S	gapdh	A0A1L8GET9	Q8AY70	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Glyceraldehyde-3-phosphate dehydrogenase.	0.763
Cdh3.S	itgb4	A0A1L8GET9	A0A1L8EMZ9	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Integrin beta.	0.469
Cdh3.S	itgb4-2	A0A1L8GET9	A0A1L8EUE6	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Integrin beta.	0.469
Cdk6.L	Esr1.S	A0A310UAR3	A0A1L8G265	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.401
Cdk6.L	actl6a	A0A310UAR3	Q7ZYI5	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Baf53a-pending-prov protein; Belongs to the actin family.	0.572
Cdk6.L	esr1	A0A310UAR3	Q6W5G7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.401
Esr1.S	Cdh3.S	A0A1L8G265	A0A1L8GET9	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.563
Esr1.S	Cdk6.L	A0A1L8G265	A0A310UAR3	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.401
Esr1.S	Gapdh.S	A0A1L8G265	Q7ZY52	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Glyceraldehyde-3-phosphate dehydrogenase.	0.515
Esr1.S	PR-2	A0A1L8G265	A0A1L8HB48	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein.	0.937
Esr1.S	actl6a	A0A1L8G265	Q7ZYI5	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Baf53a-pending-prov protein; Belongs to the actin family.	0.686
Esr1.S	cdh1	A0A1L8G265	A0A1L8GKV4	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.565