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fumC fumC ilvB-1 ilvB-1 DVU_0361 DVU_0361 DVU_0390 DVU_0390 DVU_0414 DVU_0414 icd icd ldh ldh ilvN-1 ilvN-1 glcB glcB acs acs DVU_0841 DVU_0841 DVU_0964 DVU_0964 DVU_1064 DVU_1064 ilvB-2 ilvB-2 ilvN-2 ilvN-2 ilvC ilvC porA porA porB porB DVU_1914 DVU_1914 DVU_1944 DVU_1944 DVU_1945 DVU_1945 DVU_1946 DVU_1946 DVU_1947 DVU_1947 sucCD sucCD DVU_2250 DVU_2250 DVU_2251 DVU_2251 pyk pyk DVU_2674 DVU_2674 DVU_2739 DVU_2739 acsA acsA DVU_2970 DVU_2970 leuA leuA leuC leuC leuD leuD leuB leuB poR poR pta pta ackA ackA DVU_3047 DVU_3047 DVU_3065 DVU_3065 DVU_3066 DVU_3066 ilvE ilvE aspB aspB frdC frdC fdrA fdrA frdB frdB DVU_3264 DVU_3264 DVU_3265 DVU_3265 DVU_3293 DVU_3293 DVU_3294 DVU_3294 putA putA DVU_3347 DVU_3347 DVU_3348 DVU_3348 DVU_3349 DVU_3349 DVU_3350 DVU_3350 ilvD ilvD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa)
ilvB-1Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to SP:P08142; match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118. (563 aa)
DVU_0361Acetolactate synthase III, small subunit, putative; Identified by match to protein family HMM PF01842. (107 aa)
DVU_0390Glycolate oxidase, subunit GlcD, putative; Identified by match to protein family HMM PF01565; match to protein family HMM PF02913. (460 aa)
DVU_0414NADP-dependent malic enzyme-related protein; Identified by match to protein family HMM PF00390; match to protein family HMM PF03949. (439 aa)
icdIsocitrate dehydrogenase, NADP-dependent; Identified by match to protein family HMM PF00180; match to protein family HMM TIGR00183. (380 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (309 aa)
ilvN-1Acetolactate synthase, small subunit; Identified by similarity to SP:P37252; match to protein family HMM PF01842; match to protein family HMM TIGR00119. (159 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (729 aa)
acsacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (648 aa)
DVU_0841Aspartate aminotransferase, putative; Identified by similarity to GP:15826454; match to protein family HMM PF00155. (393 aa)
DVU_0964Identified by match to protein family HMM PF00208. (997 aa)
DVU_1064Aconitate hydratase, putative; Identified by match to protein family HMM PF00330; match to protein family HMM PF00694; match to protein family HMM TIGR01342. (642 aa)
ilvB-2Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to SP:P00893; match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118. (563 aa)
ilvN-2Acetolactate synthase, small subunit; Identified by similarity to SP:P00894; match to protein family HMM PF01842; match to protein family HMM TIGR00119. (162 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
porAPyruvate ferredoxin oxidoreductase, alpha subunit; Identified by similarity to GP:43498; match to protein family HMM PF01558; match to protein family HMM PF01855. (578 aa)
porBPyruvate ferredoxin oxidoreductase, beta subunit; Identified by similarity to GP:1565184. (284 aa)
DVU_19142-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. (538 aa)
DVU_1944Pyruvate ferredoxin oxidoreductase, iron-sulfur binding subunit, putative; Identified by match to protein family HMM PF00037. (90 aa)
DVU_1945Pyruvate ferredoxin oxidoreductase, alpha subunit, putative; Identified by match to protein family HMM PF01855. (382 aa)
DVU_1946Pyruvate ferredoxin oxidoreductase, beta subunit, putative; Identified by match to protein family HMM PF02775. (276 aa)
DVU_1947Pyruvate ferredoxin oxidoreductase, gamma subunit, putative; Identified by match to protein family HMM PF01558. (207 aa)
sucCDsuccinyl-CoA synthase, beta/alpha subunits; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (709 aa)
DVU_2250Identified by match to protein family HMM PF00501. (551 aa)
DVU_2251Identified by match to protein family HMM PF01381. (186 aa)
pykPyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (469 aa)
DVU_2674Succinate dehydrogenase and fumarate reductase iron-sulfur protein; Identified by match to protein family HMM PF00037; match to protein family HMM PF00111; match to protein family HMM TIGR00384; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (239 aa)
DVU_2739Pyruvate phosphate dikinase, PEP/pyruvate binding domain protein; Identified by similarity to SP:O29548; match to protein family HMM PF00391; match to protein family HMM PF01326. (945 aa)
acsAacetoacetyl-CoA synthase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (661 aa)
DVU_2970Acetyltransferase, GNAT family; Identified by match to protein family HMM PF00583; match to protein family HMM PF02629; match to protein family HMM TIGR01369. (898 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (509 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily. (419 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (167 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (357 aa)
poRPyruvate-ferredoxin oxidoreductase; Identified by similarity to GP:1770208; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855. (1215 aa)
ptaPhosphate acetyltransferase; Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family. (704 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
DVU_3047Aminotransferase, class IV; Identified by match to protein family HMM PF01063. (315 aa)
DVU_3065Identified by match to protein family HMM PF00501. (550 aa)
DVU_3066Identified by match to protein family HMM PF01381. (189 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa)
aspBAspartate aminotransferase; Identified by similarity to SP:P23034; match to protein family HMM PF00155. (390 aa)
frdCFumarate reductase, cytochrome b subunit; Identified by similarity to SP:P17413. (216 aa)
fdrAFumarate reductase, flavoprotein subunit; Identified by similarity to GP:13160058; match to protein family HMM PF00890; match to protein family HMM PF02910; match to protein family HMM TIGR01812. (612 aa)
frdBFumarate reductase, iron-sulfur protein; Identified by similarity to SP:P17596; match to protein family HMM PF00037; match to protein family HMM TIGR00384. (247 aa)
DVU_3264Tartrate dehydratase alpha subunit, putative; Identified by similarity to SP:P05847; match to protein family HMM PF05681; match to protein family HMM TIGR00722. (279 aa)
DVU_3265Tartrate dehydratase beta subunit, putative; Identified by match to protein family HMM PF05683; match to protein family HMM TIGR00723. (183 aa)
DVU_3293Thiamine pyrophosphate-requiring enzyme; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. (547 aa)
DVU_3294Aldehyde dehydrogenase (NADP) family protein; Identified by match to protein family HMM PF00171. (464 aa)
putAProline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1006 aa)
DVU_3347Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by match to protein family HMM PF01558. (182 aa)
DVU_3348Pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit, putative. (245 aa)
DVU_3349Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain protein; Identified by match to protein family HMM PF01855. (357 aa)
DVU_3350Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037. (77 aa)
ilvDDihydroxy-acid dehydratase; Identified by similarity to SP:P51785; match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. (554 aa)
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
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