(54 nodes) Phosphatidylinositol-mediated signaling network (Anas platyrhynchos)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
	PITPNM3	PITPNM family member 3. (850 aa)
	PLCD1	Phosphoinositide phospholipase C. (779 aa)
	KBTBD2	Kelch repeat and BTB domain containing 2. (623 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	NYAP2	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2. (715 aa)
	PIK3C2G	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1476 aa)
	GATA3	GATA binding protein 3. (712 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1700 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (471 aa)
	EZR	Ezrin. (585 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1082 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (894 aa)
	PLCE1	Phosphoinositide phospholipase C. (1847 aa)
	PRR5	Proline rich 5. (413 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
	U3J282_ANAPP	Sec3-PIP2_bind domain-containing protein. (865 aa)
	PLCL1	Phosphoinositide phospholipase C. (1098 aa)
	GPR143	G protein-coupled receptor 143. (408 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (381 aa)
	U3I9N3_ANAPP	Uncharacterized protein. (511 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1035 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	PI4KA	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2123 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
	PI4KB	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (851 aa)
	PTAFR	Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (348 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (463 aa)
	PLCL2	Phosphoinositide phospholipase C. (1118 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	PITPNM2	Phosphatidylinositol transfer protein membrane associated 2. (1288 aa)
	EDN1	Endothelin 1. (203 aa)
	ENSAPLP00000016890	HSac2 domain-containing protein. (138 aa)
	PIRT	Phosphoinositide interacting regulator of transient receptor potential channels. (141 aa)
	ENSAPLP00000020256	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (681 aa)
	INPP5F	SAC domain-containing protein. (246 aa)
	CA8	Carbonic anhydrase 8; Belongs to the alpha-carbonic anhydrase family. (293 aa)
	PRR5L	Proline rich 5 like. (366 aa)
	NPR3	Natriuretic peptide receptor 3. (527 aa)
	PDGFRB	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1093 aa)
	ENSAPLP00000023272	SERPIN domain-containing protein; Belongs to the serpin family. (484 aa)
	C1QBP	Complement C1q binding protein. (162 aa)
	PLCD3	C2 domain-containing protein. (87 aa)
	PLCD4	Phosphoinositide phospholipase C. (643 aa)
	PLCZ1	Phosphoinositide phospholipase C. (646 aa)
	PLCH1	Phosphoinositide phospholipase C. (1704 aa)
	PLEKHA1	Pleckstrin homology domain containing A1. (411 aa)
	EXOC1	Exocyst complex component 1. (898 aa)
	PLCH2	Phosphoinositide phospholipase C. (1581 aa)
	ENSAPLP00000032201	Uncharacterized protein. (92 aa)
	ENSAPLP00000032683	G_PROTEIN_RECEP_F1_2 domain-containing protein. (585 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSF1R	PIK3CA	ENSAPLP00000012815	ENSAPLP00000012758	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.492
CSF1R	PIK3CB	ENSAPLP00000012815	ENSAPLP00000003138	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.469
CSF1R	PIK3CD	ENSAPLP00000012815	ENSAPLP00000007963	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.495
CSF1R	PIK3CG	ENSAPLP00000012815	ENSAPLP00000006296	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.495
CSF1R	PTEN	ENSAPLP00000012815	ENSAPLP00000015564	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.523
EDN1	PLCB1	ENSAPLP00000016469	ENSAPLP00000012734	Endothelin 1.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.632
EDN1	PLCB2	ENSAPLP00000016469	ENSAPLP00000002087	Endothelin 1.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.632
EDN1	PLCB4	ENSAPLP00000016469	ENSAPLP00000013480	Endothelin 1.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.570
ENSAPLP00000016890	ENSAPLP00000032201	ENSAPLP00000016890	ENSAPLP00000032201	HSac2 domain-containing protein.	Uncharacterized protein.	0.929
ENSAPLP00000016890	INPP5F	ENSAPLP00000016890	ENSAPLP00000020788	HSac2 domain-containing protein.	SAC domain-containing protein.	0.923
ENSAPLP00000020256	PLCB1	ENSAPLP00000020256	ENSAPLP00000012734	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.404
ENSAPLP00000020256	PLCB2	ENSAPLP00000020256	ENSAPLP00000002087	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.404
ENSAPLP00000032201	ENSAPLP00000016890	ENSAPLP00000032201	ENSAPLP00000016890	Uncharacterized protein.	HSac2 domain-containing protein.	0.929
ENSAPLP00000032201	INPP5F	ENSAPLP00000032201	ENSAPLP00000020788	Uncharacterized protein.	SAC domain-containing protein.	0.919
GPR143	PLCB1	ENSAPLP00000005232	ENSAPLP00000012734	G protein-coupled receptor 143.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.417
GPR143	PLCB2	ENSAPLP00000005232	ENSAPLP00000002087	G protein-coupled receptor 143.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.417
GPR143	PLCB4	ENSAPLP00000005232	ENSAPLP00000013480	G protein-coupled receptor 143.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.411
HTR2A	HTR2B	ENSAPLP00000011416	ENSAPLP00000015027	5-hydroxytryptamine receptor 2A.	5-hydroxytryptamine receptor 2B.	0.962
HTR2A	PLCB1	ENSAPLP00000011416	ENSAPLP00000012734	5-hydroxytryptamine receptor 2A.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.454
HTR2A	PLCB2	ENSAPLP00000011416	ENSAPLP00000002087	5-hydroxytryptamine receptor 2A.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.454