(114 nodes) Cellular senescence network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RBL2	RB transcriptional corepressor like 2. (1176 aa)
	MAPK13	Mitogen-activated protein kinase 13. (158 aa)
	TSC1	TSC complex subunit 1. (1158 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (344 aa)
	CALML4	Calmodulin like 4. (195 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2613 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	FOXO1	Forkhead box O1. (678 aa)
	MAPK12	Mitogen-activated protein kinase. (361 aa)
	MAPK11	Mitogen-activated protein kinase. (361 aa)
	U3IA71_ANAPP	MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (189 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (510 aa)
	MYBL2	MYB proto-oncogene like 2. (723 aa)
	E2F3	E2F_CC-MB domain-containing protein. (226 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1210 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (748 aa)
	HUS1	Checkpoint protein; Belongs to the HUS1 family. (277 aa)
	VDAC3	Voltage dependent anion channel 3. (296 aa)
	RAD1	RAD1 checkpoint DNA exonuclease. (281 aa)
	U3IGX0_ANAPP	Uncharacterized protein. (463 aa)
	SMAD3	Mothers against decapentaplegic homolog. (426 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (405 aa)
	RB1	RB transcriptional corepressor 1. (855 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	CDC25A	Cell division cycle 25A. (434 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (608 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	MCU	Mitochondrial calcium uniporter. (354 aa)
	U3INX3_ANAPP	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
	NRAS	Uncharacterized protein. (189 aa)
	CAPN2	Calpain 2; Belongs to the peptidase C2 family. (700 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (339 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	FBXW11	F-box and WD repeat domain containing 11. (563 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
	MDM2	Uncharacterized protein. (423 aa)
	FOXO3	Fork-head domain-containing protein. (665 aa)
	FOXM1	Forkhead box M1. (800 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	PIK3R2	Uncharacterized protein. (731 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (392 aa)
	E2F1	E2F transcription factor 1. (388 aa)
	TGFB3	Transforming growth factor beta 3. (458 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	VDAC2	Voltage dependent anion channel 2. (296 aa)
	CXCL8-3	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
	ATM	Non-specific serine/threonine protein kinase. (2967 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2182 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (384 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (676 aa)
	RASSF5	Ras association domain family member 5. (255 aa)
	PPID	Peptidylprolyl isomerase D. (370 aa)
	LIN52	Lin-52 DREAM MuvB core complex component. (112 aa)
	CHEK1	Checkpoint kinase 1. (435 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2699 aa)
	VDAC1	Voltage dependent anion channel 1. (283 aa)
	TRAF3IP2	Uncharacterized protein. (392 aa)
	TRPM7	Transient receptor potential cation channel subfamily M member 7. (1821 aa)
	MAPKAPK2	MAPK activated protein kinase 2. (397 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (464 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	CAPN11	Uncharacterized protein; Belongs to the peptidase C2 family. (800 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1. (100 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	E2F5	E2F transcription factor 5. (359 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (291 aa)
	RRAS2	RAS related 2. (203 aa)
	E2F4	E2F_TDP domain-containing protein. (97 aa)
	MAP2K3	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (348 aa)
	ATR	Uncharacterized protein. (125 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (998 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (507 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (575 aa)
	CCND1	Cyclin_C domain-containing protein. (153 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	IL6	Uncharacterized protein. (350 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (371 aa)
	GATA4	GATA-N domain-containing protein. (261 aa)
	MRE11	MRE11 homolog, double strand break repair nuclease. (230 aa)
	ETS1	ETS proto-oncogene 1, transcription factor. (491 aa)
	LIN54-2	Uncharacterized protein. (59 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (572 aa)
	NFATC2	Nuclear factor of activated T cells 2. (930 aa)
	HIPK1	Homeodomain interacting protein kinase 1. (1608 aa)
	NFATC1	Nuclear factor of activated T cells 1. (907 aa)
	MRAS	Muscle RAS oncogene homolog. (208 aa)
	CXCL8-5	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (277 aa)
	ENSAPLP00000025322	ANK_REP_REGION domain-containing protein. (136 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2677 aa)
	CXCL8-6	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (155 aa)
	SLC25A4	Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (455 aa)
	ENSAPLP00000027723	calpain_III domain-containing protein. (76 aa)
	SQSTM1	Uncharacterized protein. (77 aa)
	PPP3R1	Uncharacterized protein. (170 aa)
	SLC25A5	Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (442 aa)
	SLC25A6	Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (331 aa)
	SIRT1	Sirtuin 1. (777 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (238 aa)
	CDKN1A-2	Uncharacterized protein. (182 aa)
	CCND3	Cyclin_C domain-containing protein; Belongs to the cyclin family. (321 aa)
	HIPK4	Homeodomain interacting protein kinase 4. (561 aa)
	RHEB	Ras homolog, mTORC1 binding. (184 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (335 aa)
	NFATC3	Nuclear factor of activated T cells 3. (1123 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (350 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT3	ENSAPLP00000016229	ENSAPLP00000011266	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	CDKN1A-2	ENSAPLP00000016229	ENSAPLP00000031755	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.944
AKT1	FOXO1	ENSAPLP00000016229	ENSAPLP00000003516	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O1.	0.972
AKT1	FOXO3	ENSAPLP00000016229	ENSAPLP00000011053	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.971
AKT1	MAPK1	ENSAPLP00000016229	ENSAPLP00000005723	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.925
AKT1	MDM2	ENSAPLP00000016229	ENSAPLP00000010914	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.970
AKT1	MTOR	ENSAPLP00000016229	ENSAPLP00000007032	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.967
AKT1	PIK3CA	ENSAPLP00000016229	ENSAPLP00000012758	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.966
AKT1	PIK3CB	ENSAPLP00000016229	ENSAPLP00000003138	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.970
AKT1	PIK3CD	ENSAPLP00000016229	ENSAPLP00000007963	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.948
AKT1	PIK3R1	ENSAPLP00000016229	ENSAPLP00000017936	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.944
AKT1	PIK3R2	ENSAPLP00000016229	ENSAPLP00000011511	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.944
AKT1	PTEN	ENSAPLP00000016229	ENSAPLP00000015564	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.610
AKT1	RHEB	ENSAPLP00000016229	ENSAPLP00000032408	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ras homolog, mTORC1 binding.	0.416
AKT1	TSC1	ENSAPLP00000016229	ENSAPLP00000001959	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	TSC complex subunit 1.	0.970
AKT1	U3IGX0_ANAPP	ENSAPLP00000016229	ENSAPLP00000006492	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.944
AKT1	ZFP36L1	ENSAPLP00000016229	ENSAPLP00000032425	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	ZFP36 ring finger protein like 1.	0.425
AKT1	ZFP36L2	ENSAPLP00000016229	ENSAPLP00000023834	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	ZFP36 ring finger protein like 2.	0.421
AKT3	AKT1	ENSAPLP00000011266	ENSAPLP00000016229	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT3	CDKN1A-2	ENSAPLP00000011266	ENSAPLP00000031755	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.944