STRINGSTRING
FGF18 FGF18 NRAS NRAS UBA52 UBA52 CSDE1 CSDE1 PIK3R1 PIK3R1 SHC1 SHC1 FNDC3A FNDC3A PLCG1 PLCG1 MAPK1 MAPK1 PIK3CA PIK3CA MAPK3 MAPK3 MKNK2 MKNK2 FGF8 FGF8 Ubc Ubc FGFR3 FGFR3 Frs2 Frs2 FGF1 FGF1 Ppp2ca Ppp2ca Fgf23 Fgf23 H920_02493 H920_02493 RPS27A RPS27A Mknk1 Mknk1 KRAS KRAS FGF5 FGF5 HRAS HRAS SPRY3 SPRY3 PPP2CB PPP2CB SPRY2 SPRY2 FNDC3B FNDC3B ENSFDAP00000009348 ENSFDAP00000009348 GAB1 GAB1 SOS1 SOS1 FGF20 FGF20 FRS3 FRS3 GRB2 GRB2 Fgf4 Fgf4 CBL CBL ENSFDAP00000002920 ENSFDAP00000002920 GALNT3 GALNT3 FGF9 FGF9 Ppp2r1a Ppp2r1a FGF17 FGF17 FGF16 FGF16 BRAF BRAF PTPN11 PTPN11 ENSFDAP00000000144 ENSFDAP00000000144 Fgf2 Fgf2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
UBA52KxDL motif containing 1. (232 aa)
CSDE1Cold shock domain-containing protein E1. (798 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
SHC1SHC-transforming protein 1. (583 aa)
FNDC3AFibronectin type-III domain-containing protein 3A. (1198 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2. (459 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
UbcPolyubiquitin-B. (235 aa)
FGFR3Fibroblast growth factor receptor 3. (748 aa)
Frs2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Ppp2caSerine/threonine-protein phosphatase. (275 aa)
Fgf23Fibroblast growth factor 23. (129 aa)
H920_02493Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
Mknk1MAP kinase-interacting serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (415 aa)
KRASGTPase HRas. (189 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (315 aa)
HRASHRas proto-oncogene, GTPase. (191 aa)
SPRY3Protein sprouty like protein 3. (288 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
SPRY2Protein sprouty like protein 2. (315 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1206 aa)
ENSFDAP00000009348annotation not available (427 aa)
GAB1GRB2-associated-binding protein 1. (698 aa)
SOS1Son of sevenless like protein 1. (1289 aa)
FGF20Fibroblast growth factor 20. (184 aa)
FRS3Fibroblast growth factor receptor substrate 3. (486 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
Fgf4Fibroblast growth factor 4. (52 aa)
CBLE3 ubiquitin-protein ligase CBL. (851 aa)
ENSFDAP00000002920annotation not available (87 aa)
GALNT3Polypeptide N-acetylgalactosaminyltransferase. (633 aa)
FGF9Fibroblast growth factor 9. (208 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (573 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
BRAFSerine/threonine-protein kinase B-raf. (740 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (600 aa)
ENSFDAP00000000144annotation not available (263 aa)
Fgf2Fibroblast growth factor 2. (129 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.