(5 nodes) Mixed, incl. Hyaluronic acid, and Fibronectin, type I network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FN1	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). (2526 aa)
	VCAN	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. (3559 aa)
	COL3A1	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
	DCN	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (357 aa)
	ELN	Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. (811 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COL3A1	DCN	ENSGALP00000051057	ENSGALP00000062069	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.985
COL3A1	ELN	ENSGALP00000051057	ENSGALP00000069288	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely.	0.999
COL3A1	FN1	ENSGALP00000051057	ENSGALP00000005653	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity).	0.999
COL3A1	VCAN	ENSGALP00000051057	ENSGALP00000025144	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.	0.852
DCN	COL3A1	ENSGALP00000062069	ENSGALP00000051057	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	0.985
DCN	ELN	ENSGALP00000062069	ENSGALP00000069288	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely.	0.926
DCN	FN1	ENSGALP00000062069	ENSGALP00000005653	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity).	0.835
DCN	VCAN	ENSGALP00000062069	ENSGALP00000025144	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.	0.931
ELN	COL3A1	ENSGALP00000069288	ENSGALP00000051057	Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely.	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	0.999
ELN	DCN	ENSGALP00000069288	ENSGALP00000062069	Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely.	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.926
ELN	FN1	ENSGALP00000069288	ENSGALP00000005653	Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely.	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity).	0.983
ELN	VCAN	ENSGALP00000069288	ENSGALP00000025144	Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely.	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.	0.670
FN1	COL3A1	ENSGALP00000005653	ENSGALP00000051057	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity).	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	0.999
FN1	DCN	ENSGALP00000005653	ENSGALP00000062069	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity).	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.835
FN1	ELN	ENSGALP00000005653	ENSGALP00000069288	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity).	Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely.	0.983
FN1	VCAN	ENSGALP00000005653	ENSGALP00000025144	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity).	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.	0.869
VCAN	COL3A1	ENSGALP00000025144	ENSGALP00000051057	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	0.852
VCAN	DCN	ENSGALP00000025144	ENSGALP00000062069	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.931
VCAN	ELN	ENSGALP00000025144	ENSGALP00000069288	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.	Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely.	0.670
VCAN	FN1	ENSGALP00000025144	ENSGALP00000005653	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity).	0.869