STRINGSTRING
CDH1 CDH1 ETS1 ETS1 NKX2-5 NKX2-5 GDF3 GDF3 CBFB CBFB GFI1B GFI1B GPER1 GPER1 TWIST2 TWIST2 SOX8 SOX8 GATA5 GATA5 WWOX WWOX SEMA3D SEMA3D ZEB1 ZEB1 TFAP2C TFAP2C SNAI1 SNAI1 TLE3 TLE3 TBX5 TBX5 LMCD1 LMCD1 LHX8 LHX8 ESR2 ESR2 EP300 EP300 WT1 WT1 SOX10 SOX10 CFC1 CFC1 TFAP2A TFAP2A CITED2 CITED2 MSX1 MSX1 GREB1 GREB1 TFAP2B TFAP2B TFCP2L1 TFCP2L1 GATA2 GATA2 GATA4 GATA4 GATA6 GATA6 IRX4 IRX4 ETV6 ETV6 PAX9 PAX9 TBX22 TBX22 TCF3 TCF3 EOMES EOMES KLF4 KLF4 FOXE3 FOXE3 TCF21 TCF21 NANOG NANOG ESRRB ESRRB SOX17 SOX17 FOXA2 FOXA2 TBX3 TBX3 TWIST1 TWIST1 SOX2 SOX2 LMO2 LMO2 HAND2 HAND2 SALL4 SALL4 PITX2 PITX2 MSX2 MSX2 KCTD1 KCTD1 TBX18 TBX18 OSR2 OSR2 FOXF1 FOXF1 ERG ERG ELF5 ELF5 RUNX1T1 RUNX1T1 FOXA1 FOXA1 ID2 ID2 MEF2C MEF2C TBX20 TBX20 TFAP2E TFAP2E LDB1 LDB1 ZIC1 ZIC1 ZIC3 ZIC3 ZFPM2 ZFPM2 SOX7 SOX7 SNAI2 SNAI2 SHOX2 SHOX2 TBX2 TBX2 LEFTY1 LEFTY1 NKX3-2 NKX3-2 HHEX HHEX RUNX1 RUNX1 KLF-4 KLF-4 ETS2 ETS2 ENSGALP00000067067 ENSGALP00000067067 DLX3 DLX3 ENSGALP00000067176 ENSGALP00000067176 ZFPM1 ZFPM1 GATA3 GATA3 NPDC1 NPDC1 ZEB2 ZEB2 RUNX3 RUNX3 BARX1 BARX1 NRIP1 NRIP1 TAL1 TAL1 ENSGALP00000073834 ENSGALP00000073834 ESR1 ESR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7. (887 aa)
ETS1Transforming protein p68/c-ets-1; Probable transcription factor. (497 aa)
NKX2-5Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter. Belongs to the NK-2 homeobox family. (294 aa)
GDF3CVg1 protein. (373 aa)
CBFBUncharacterized protein. (187 aa)
GFI1BZinc finger protein Gfi-1b; Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. (337 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
TWIST2Dermo protein. (160 aa)
SOX8Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. (470 aa)
GATA5Transcription factor GATA-5; Probably involved in bone morphogenetic protein (BMP)- mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (391 aa)
WWOXWW domain-containing oxidoreductase; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family. (414 aa)
SEMA3DSemaphorin-3D; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin; Belongs to the semaphorin family. (761 aa)
ZEB1Zinc finger E-box-binding homeobox 1; Acts as a transcriptional repressor. Positively regulates neuronal differentiation. Represses transcription by binding to the E box-containing promoter (By similarity). Binds to delta 1-crystallin enhancer core and represses lens-specific transcription. It binds as well many other non-lens specific DNA sequences. (1114 aa)
TFAP2CTranscription factor AP-2 gamma. (448 aa)
SNAI1Snail like protein. (256 aa)
TLE3TLE family member 3, transcriptional corepressor. (779 aa)
TBX5T-box transcription factor TBX5; DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. May bind to the core DNA motif of promoters. (521 aa)
LMCD1LIM and cysteine rich domains 1. (360 aa)
LHX8Uncharacterized protein. (347 aa)
ESR2Estrogen receptor beta; Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Belongs to the nuclear hormone receptor family. NR3 subfamily. (472 aa)
EP300E1A binding protein p300. (2450 aa)
WT1Uncharacterized protein. (417 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. (461 aa)
CFC1Cryptic protein; May play a role in mesoderm and/or neural patterning during gastrulation. (193 aa)
TFAP2ATF_AP-2 domain-containing protein. (437 aa)
CITED2Cited2/melanocyte specific gene-related gene 1 MRG1. (236 aa)
MSX1Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa)
GREB1Uncharacterized protein. (1937 aa)
TFAP2BTranscription factor AP-2 beta. (449 aa)
TFCP2L1Transcription factor CP2 like 1. (475 aa)
GATA2GATA-binding factor 2; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (466 aa)
GATA4Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). (410 aa)
GATA6Transcription factor GATA-6; Transcriptional activator. (387 aa)
IRX4Iroquois-class homeodomain protein IRX-4; Regulates the chamber-specific expression of myosin isoforms by activating the expression of the ventricle myosin heavy chain-1 (Vmhc1) and suppressing the expression of the atrial myosin heavy chain-1 (Amhc1) in the ventricles. May play a critical role in establishing chamber-specific gene expression in the developing heart; Belongs to the TALE/IRO homeobox family. (485 aa)
ETV6Uncharacterized protein. (451 aa)
PAX9Paired box protein Pax-9. (341 aa)
TBX22T-box transcription factor Tbx22. (489 aa)
TCF3BHLH domain-containing protein. (682 aa)
EOMEST-box_assoc domain-containing protein. (661 aa)
KLF4Uncharacterized protein. (111 aa)
FOXE3Forkhead box protein D3; Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri- implantation stages of embryogenesis. (386 aa)
TCF21BHLH domain-containing protein. (179 aa)
NANOGHomeobox protein NANOG; Transcription factor required for the maintenance of pluripotency and self-renewal of embryonic stem cells. Belongs to the Nanog homeobox family. (308 aa)
ESRRBEstrogen related receptor beta. (454 aa)
SOX17Uncharacterized protein. (410 aa)
FOXA2Fork-head domain-containing protein. (438 aa)
TBX3T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa)
TWIST1CTwist. (190 aa)
SOX2Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
LMO2LIM domain only 2. (216 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud. (216 aa)
SALL4Uncharacterized protein. (1108 aa)
PITX2Pituitary homeobox 2; May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis. (333 aa)
MSX2Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Binds to DNA (By similarity). Morphogenetic role; Belongs to the Msh homeobox family. (259 aa)
KCTD1Potassium channel tetramerization domain containing 1. (816 aa)
TBX18Uncharacterized protein. (589 aa)
OSR2Uncharacterized protein. (412 aa)
FOXF1Forkhead box F1. (407 aa)
ERGTranscriptional regulator Erg; Acts as a transcriptional activator. (485 aa)
ELF5E74 like ETS transcription factor 5. (258 aa)
RUNX1T1Uncharacterized protein. (604 aa)
FOXA1Forkhead box A1. (442 aa)
ID2Transcriptional regulator Id2. (134 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
TBX20T-box transcription factor TBX20; Acts as a transcriptional regulator involved in heart developmental processes. (440 aa)
TFAP2ETranscription factor AP-2 epsilon. (541 aa)
LDB1LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. (416 aa)
ZIC1Zinc finger protein ZIC 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). (444 aa)
ZIC3Zinc finger protein Zic3. (464 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1151 aa)
SOX7Uncharacterized protein. (377 aa)
SNAI2Uncharacterized protein. (258 aa)
SHOX2Short stature homeobox 2. (316 aa)
TBX2T-box transcription factor 2. (693 aa)
LEFTY1Left-right determination factor. (362 aa)
NKX3-2Homeobox domain-containing protein. (275 aa)
HHEXHematopoietically-expressed homeobox protein HHEX; Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. (320 aa)
RUNX1Runt-related transcription factor. (472 aa)
KLF-4Uncharacterized protein. (481 aa)
ETS2Protein C-ets-2; Probable transcription factor; Belongs to the ETS family. (479 aa)
ENSGALP00000067067Homeobox domain-containing protein. (190 aa)
DLX3Homeobox domain-containing protein. (451 aa)
ENSGALP00000067176TGF_BETA_2 domain-containing protein. (115 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1079 aa)
GATA3GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
NPDC1POU domain, class 5, transcription factor 3; Required for the maintenance of pluripotency and self-renewal of embryonic stem cells. Transcriptional activator that binds the DNA consensus sequence 5'-ATGCAAAT-3'; Belongs to the POU transcription factor family. (427 aa)
ZEB2Smad-interacting protein 1. (1214 aa)
RUNX3RUNX family transcription factor 3. (607 aa)
BARX1Homeobox protein BarH-like 1b; Transcription factor which is involved with the serum response factor (SRF) in the smooth muscle cell-specific transcription of the beta-tropomyosin gene in the upper digestive organs and their attached arteries; Belongs to the BAR homeobox family. (346 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
TAL1T-cell acute lymphocytic leukemia protein 1 homolog; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. (396 aa)
ENSGALP00000073834Uncharacterized protein. (1340 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (651 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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