(17 nodes) Mixed, incl. Interleukin-17, and interleukin-17 receptor activity network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL17RD	Interleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity). (741 aa)
	IL13	Interleukin-13. (138 aa)
	IL2	Interleukin; Belongs to the IL-15/IL-21 family. (143 aa)
	IL17F	Uncharacterized protein. (169 aa)
	IL17A	Uncharacterized protein. (169 aa)
	IL4	Interleukin 4. (136 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (136 aa)
	IL3	Uncharacterized protein. (138 aa)
	IL17C	Interleukin 17C. (189 aa)
	IL9	Interleukin-9. (138 aa)
	IL17B	Interleukin 17B. (172 aa)
	KK34	Uncharacterized protein. (169 aa)
	LITAF	Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines. (148 aa)
	IL17RA	SEFIR domain-containing protein. (978 aa)
	ENSGALP00000071126	IL17_R_N domain-containing protein. (232 aa)
	CSF2	Uncharacterized protein. (144 aa)
	IL9R	Fibronectin type-III domain-containing protein. (481 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSF2	IL13	ENSGALP00000071385	ENSGALP00000010986	Uncharacterized protein.	Interleukin-13.	0.859
CSF2	IL17A	ENSGALP00000071385	ENSGALP00000026862	Uncharacterized protein.	Uncharacterized protein.	0.697
CSF2	IL2	ENSGALP00000071385	ENSGALP00000019308	Uncharacterized protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.885
CSF2	IL3	ENSGALP00000071385	ENSGALP00000039188	Uncharacterized protein.	Uncharacterized protein.	0.858
CSF2	IL4	ENSGALP00000071385	ENSGALP00000039130	Uncharacterized protein.	Interleukin 4.	0.842
CSF2	IL5	ENSGALP00000071385	ENSGALP00000039137	Uncharacterized protein.	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.	0.859
CSF2	IL9	ENSGALP00000071385	ENSGALP00000050876	Uncharacterized protein.	Interleukin-9.	0.783
CSF2	KK34	ENSGALP00000071385	ENSGALP00000055860	Uncharacterized protein.	Uncharacterized protein.	0.704
CSF2	LITAF	ENSGALP00000071385	ENSGALP00000066763	Uncharacterized protein.	Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines.	0.842
ENSGALP00000071126	IL17B	ENSGALP00000071126	ENSGALP00000053084	IL17_R_N domain-containing protein.	Interleukin 17B.	0.528
ENSGALP00000071126	IL17C	ENSGALP00000071126	ENSGALP00000043267	IL17_R_N domain-containing protein.	Interleukin 17C.	0.647
ENSGALP00000071126	IL17F	ENSGALP00000071126	ENSGALP00000026861	IL17_R_N domain-containing protein.	Uncharacterized protein.	0.626
ENSGALP00000071126	IL17RA	ENSGALP00000071126	ENSGALP00000070182	IL17_R_N domain-containing protein.	SEFIR domain-containing protein.	0.555
ENSGALP00000071126	IL17RD	ENSGALP00000071126	ENSGALP00000008813	IL17_R_N domain-containing protein.	Interleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity).	0.646
IL13	CSF2	ENSGALP00000010986	ENSGALP00000071385	Interleukin-13.	Uncharacterized protein.	0.859
IL13	IL17A	ENSGALP00000010986	ENSGALP00000026862	Interleukin-13.	Uncharacterized protein.	0.893
IL13	IL17B	ENSGALP00000010986	ENSGALP00000053084	Interleukin-13.	Interleukin 17B.	0.474
IL13	IL17F	ENSGALP00000010986	ENSGALP00000026861	Interleukin-13.	Uncharacterized protein.	0.595
IL13	IL2	ENSGALP00000010986	ENSGALP00000019308	Interleukin-13.	Interleukin; Belongs to the IL-15/IL-21 family.	0.899
IL13	IL3	ENSGALP00000010986	ENSGALP00000039188	Interleukin-13.	Uncharacterized protein.	0.859