STRINGSTRING
CTRB2 CTRB2 PGA3 PGA3 REN REN MMEL1 MMEL1 LVRN LVRN LOC420160 LOC420160 BLMH BLMH CTSD CTSD CPB1 CPB1 F1N9G3_CHICK F1N9G3_CHICK TMPRSS13 TMPRSS13 CPA2 CPA2 CPA1 CPA1 FURIN FURIN CPO CPO PNLIPRP1 PNLIPRP1 F1N9P4_CHICK F1N9P4_CHICK MME MME LGMN LGMN AGT AGT TMPRSS11F TMPRSS11F XPNPEP3 XPNPEP3 CTSV CTSV SLC6A18 SLC6A18 CSTB CSTB NLN NLN PREP PREP LRPAP1 LRPAP1 TMPRSS2 TMPRSS2 ACE2 ACE2 CTSC CTSC LRP11 LRP11 CPA5 CPA5 PIFO PIFO ACE ACE R4GFF1_CHICK R4GFF1_CHICK LOC100859837 LOC100859837 XPNPEP2 XPNPEP2 TMEM27 TMEM27 GASTL GASTL CST3 CST3 PNLIPRP3 PNLIPRP3 TMPRSS12 TMPRSS12 CTRC CTRC CEL CEL CELA1 CELA1 P3H2 P3H2 SELENBP1L3-2 SELENBP1L3-2 IDE IDE F5 F5 BACE2 BACE2 TLL2 TLL2 ENPEP ENPEP SPINK6 SPINK6 CTSZ CTSZ CTSH CTSH PGA5 PGA5 LOC107049865 LOC107049865 CTRL CTRL THOP1 THOP1 DPP4 DPP4 PDIA2 PDIA2 GRN GRN CLPS CLPS ENSGALP00000055248 ENSGALP00000055248 APEH APEH LRP1 LRP1 DNPEP DNPEP AGTR1 AGTR1 PEPD PEPD PRSS3 PRSS3 UVS.2L UVS.2L DNASE1 DNASE1 LOC771362 LOC771362 CTSG CTSG ERAP1 ERAP1 LOC112529919 LOC112529919 PRSS57 PRSS57 CTSS CTSS CYSP1L CYSP1L ENSGALP00000067152 ENSGALP00000067152 AGTR2 AGTR2 ENSGALP00000068914 ENSGALP00000068914 ENSGALP00000069016 ENSGALP00000069016 ENSGALP00000069448 ENSGALP00000069448 DMBT1 DMBT1 ZNF644 ZNF644 XPNPEP1 XPNPEP1 CELA2A CELA2A ENSGALP00000070361 ENSGALP00000070361 ENSGALP00000071036 ENSGALP00000071036 DENND2D DENND2D ENSGALP00000071622 ENSGALP00000071622 NPEPPS NPEPPS PCSK7 PCSK7 ENSGALP00000072973 ENSGALP00000072973 LOC101749216 LOC101749216 LOC100857834 LOC100857834 LOC100858579 LOC100858579 ENSGALP00000073762 ENSGALP00000073762 TMPRSS11D TMPRSS11D ENSGALP00000074196 ENSGALP00000074196
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTRB2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (269 aa)
PGA3Embryonic pepsinogen. (383 aa)
RENRenin; Belongs to the peptidase A1 family. (423 aa)
MMEL1Membrane metalloendopeptidase like 1. (773 aa)
LVRNAminopeptidase. (958 aa)
LOC420160Uncharacterized protein; Belongs to the peptidase C1 family. (336 aa)
BLMHBleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity; Belongs to the peptidase C1 family. (455 aa)
CTSDCathepsin D heavy chain; Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL. (398 aa)
CPB1Uncharacterized protein. (417 aa)
F1N9G3_CHICKPhospholipase A(2). (111 aa)
TMPRSS13Transmembrane serine protease 13; Belongs to the peptidase S1 family. (471 aa)
CPA2Uncharacterized protein. (508 aa)
CPA1Uncharacterized protein. (435 aa)
FURINTrans Golgi network protease furin; Belongs to the peptidase S8 family. (789 aa)
CPOCarboxypeptidase O. (379 aa)
PNLIPRP1Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (467 aa)
F1N9P4_CHICKPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (248 aa)
MMENeprilysin. (750 aa)
LGMNLegumain. (431 aa)
AGTAngiotensinogen; Belongs to the serpin family. (464 aa)
TMPRSS11FSEA domain-containing protein. (240 aa)
XPNPEP3X-prolyl aminopeptidase 3. (502 aa)
CTSVCathepsin L1 heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (353 aa)
SLC6A18Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa)
CSTBCystatin domain-containing protein; Belongs to the cystatin family. (98 aa)
NLNNeurolysin. (698 aa)
PREPUncharacterized protein. (842 aa)
LRPAP1Uncharacterized protein. (348 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (486 aa)
ACE2Angiotensin-converting enzyme. (808 aa)
CTSCPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (532 aa)
LRP11LDL receptor related protein 11. (247 aa)
CPA5Uncharacterized protein. (419 aa)
PIFOPrimary cilia formation. (198 aa)
ACEAngiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. (1281 aa)
R4GFF1_CHICKUncharacterized protein. (150 aa)
LOC100859837Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (618 aa)
XPNPEP2X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family. (681 aa)
TMEM27Collectrin domain-containing protein. (226 aa)
GASTLPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (394 aa)
CST3Cystatin; This protein binds tightly to and inhibits a variety of thiol proteases including ficin, papain, and cathepsins B, C, H, and L. Although isolated from egg white, it is also present in serum. (209 aa)
PNLIPRP3Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (341 aa)
TMPRSS12Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (277 aa)
CTRCPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (267 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (555 aa)
CELA1Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (456 aa)
P3H2Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (By similarity). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position (By similarity). (694 aa)
SELENBP1L3-2Uncharacterized protein. (447 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (964 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (2025 aa)
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (633 aa)
TLL2Metalloendopeptidase. (978 aa)
ENPEPAminopeptidase. (943 aa)
SPINK6Serine peptidase inhibitor, Kazal type 6. (115 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (325 aa)
CTSHUncharacterized protein; Belongs to the peptidase C1 family. (403 aa)
PGA5Pepsin A; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent; Belongs to the peptidase A1 family. (382 aa)
LOC107049865Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (248 aa)
CTRLPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (413 aa)
THOP1Thimet oligopeptidase 1. (685 aa)
DPP4Uncharacterized protein; Belongs to the peptidase S9B family. (760 aa)
PDIA2Protein disulfide isomerase family A member 2. (539 aa)
GRNUncharacterized protein. (287 aa)
CLPSColipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. (115 aa)
ENSGALP00000055248Peptidase S1 domain-containing protein. (109 aa)
APEHPeptidase_S9 domain-containing protein. (739 aa)
LRP1Low-density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an alpha-2-macroglobulin receptor. Belongs to the LDLR family. (4583 aa)
DNPEPUncharacterized protein; Belongs to the peptidase M18 family. (568 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. (359 aa)
PEPDAMP_N domain-containing protein. (497 aa)
PRSS3Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (259 aa)
UVS.2LMetalloendopeptidase. (281 aa)
DNASE1Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (By similarity). Binds specifically to G-actin and blocks actin polymerization (By similarity). (282 aa)
LOC771362Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (447 aa)
CTSGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
ERAP1Aminopeptidase. (929 aa)
LOC112529919Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (268 aa)
PRSS57Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (488 aa)
CTSSUncharacterized protein; Belongs to the peptidase C1 family. (508 aa)
CYSP1LUncharacterized protein. (228 aa)
ENSGALP00000067152BPTI/Kunitz inhibitor domain-containing protein. (134 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (372 aa)
ENSGALP00000068914Peptidase S1 domain-containing protein. (165 aa)
ENSGALP00000069016Peptidase S1 domain-containing protein. (179 aa)
ENSGALP00000069448Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (409 aa)
DMBT1Uncharacterized protein. (539 aa)
ZNF644Zinc finger protein 644. (1198 aa)
XPNPEP1X-prolyl aminopeptidase 1; Belongs to the peptidase M24B family. (623 aa)
CELA2APeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (323 aa)
ENSGALP00000070361Uncharacterized protein. (250 aa)
ENSGALP00000071036Uncharacterized protein. (355 aa)
DENND2DDENN domain containing 2D. (625 aa)
ENSGALP00000071622Peptidase S1 domain-containing protein. (451 aa)
NPEPPSAminopeptidase puromycin sensitive. (1113 aa)
PCSK7P/Homo B domain-containing protein. (799 aa)
ENSGALP00000072973BPTI/Kunitz inhibitor domain-containing protein. (62 aa)
LOC101749216Kazal-like domain-containing protein. (73 aa)
LOC100857834Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (374 aa)
LOC100858579Peptidase S1 domain-containing protein. (243 aa)
ENSGALP00000073762Peptidase S1 domain-containing protein. (182 aa)
TMPRSS11DPeptidase S1 domain-containing protein. (68 aa)
ENSGALP00000074196Peptidase S1 domain-containing protein. (101 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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