(56 nodes) Mixed, incl. Myofibril assembly, and Skeletal muscle cell differentiation network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UNC45B	Unc-45 myosin chaperone B. (929 aa)
	MYPN	Myopalladin. (991 aa)
	CSRP3	Uncharacterized protein. (194 aa)
	MYOM3	Myomesin 3. (1373 aa)
	DUPD1	Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. (214 aa)
	MYOZ1	Myozenin 1. (278 aa)
	KLHL40	Kelch like family member 40. (587 aa)
	ANKRD2	Ankyrin repeat domain 2 protein. (334 aa)
	LMOD2	Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function (By similarity); Belongs to the tropomodulin family. (552 aa)
	ASB15	Ankyrin repeat and SOCS box containing 15. (590 aa)
	NRAP	Nebulin related anchoring protein. (1736 aa)
	BEST3	Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (669 aa)
	MYOM2	M-protein, striated muscle; Is a structural constituent of myofibrillar M-band in striated muscle. (1450 aa)
	KLHL34	Kelch like family member 34. (595 aa)
	METTL21EP	Uncharacterized protein. (256 aa)
	LMOD3	Leiomodin 3. (524 aa)
	POPDC2	Uncharacterized protein. (356 aa)
	LSMEM1	Leucine rich single-pass membrane protein 1. (158 aa)
	TMEM8C	Uncharacterized protein. (220 aa)
	MUSTN1	Musculoskeletal embryonic nuclear protein 1; May be involved in the development and regeneration of the musculoskeletal system; Belongs to the MUSTANG family. (78 aa)
	XIRP1	Xin actin-binding repeat-containing protein 1; Protects actin filaments from depolymerization (By similarity). Involved in cardiac morphogenesis. (2563 aa)
	MYOD1	Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (299 aa)
	MYOG	Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (227 aa)
	KLHL33	BTB domain-containing protein. (782 aa)
	MYH1D	Myosin-1B; Muscle contraction. (1940 aa)
	MYF5	Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (258 aa)
	MYOT	Myotilin. (513 aa)
	PAX7	PAX7 protein. (524 aa)
	TMEM182	Transmembrane protein 182. (233 aa)
	MEF2D	MADS-box domain-containing protein. (570 aa)
	NEBL-2	Uncharacterized protein. (334 aa)
	CAPN3	Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (810 aa)
	ACTN2	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (923 aa)
	NEBL	Nebulette. (668 aa)
	SYNPO2L	Synaptopodin 2 like. (1080 aa)
	MYOM1	Uncharacterized protein. (1671 aa)
	PAX3	Paired-box transcription factor protein PAX3. (484 aa)
	MLIP	Uncharacterized protein. (372 aa)
	MYOZ2	Uncharacterized protein. (263 aa)
	SMYD1	Uncharacterized protein. (491 aa)
	PPP1R3A	Protein phosphatase 1 regulatory subunit 3A. (1088 aa)
	NEBL1	Uncharacterized protein. (2613 aa)
	MEF2B	Myocyte enhancer factor 2B. (398 aa)
	DUSP22AL	DSPc domain-containing protein. (180 aa)
	MYBPC2	Myosin-binding protein C, fast-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. (254 aa)
	MYOZ3	Myozenin 3. (241 aa)
	CORO6	Coronin; Belongs to the WD repeat coronin family. (698 aa)
	DYSF	Uncharacterized protein. (2110 aa)
	ENSGALP00000068828	Uncharacterized protein. (185 aa)
	SMPX	Uncharacterized protein. (88 aa)
	ENSGALP00000070799	SH3 domain-containing protein. (249 aa)
	MYF6	Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. (341 aa)
	MEF2A	Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Mediates cellular functions in skeletal and cardiac muscle development. (545 aa)
	FBXO40	F-box protein 40. (707 aa)
	ENSGALP00000073678	Uncharacterized protein. (419 aa)
	SCO1	SCO cytochrome c oxidase assembly protein 1. (558 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN2	CAPN3	ENSGALP00000054549	ENSGALP00000053715	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family.	0.476
ACTN2	CSRP3	ENSGALP00000054549	ENSGALP00000006426	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Uncharacterized protein.	0.694
ACTN2	LMOD2	ENSGALP00000054549	ENSGALP00000014297	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function (By similarity); Belongs to the tropomodulin family.	0.421
ACTN2	MYBPC2	ENSGALP00000054549	ENSGALP00000067253	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Myosin-binding protein C, fast-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.	0.533
ACTN2	MYF6	ENSGALP00000054549	ENSGALP00000070971	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.	0.447
ACTN2	MYH1D	ENSGALP00000054549	ENSGALP00000041897	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Myosin-1B; Muscle contraction.	0.725
ACTN2	MYOD1	ENSGALP00000054549	ENSGALP00000038684	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.447
ACTN2	MYOG	ENSGALP00000054549	ENSGALP00000039912	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).	0.435
ACTN2	MYOM1	ENSGALP00000054549	ENSGALP00000055845	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Uncharacterized protein.	0.431
ACTN2	MYOM2	ENSGALP00000054549	ENSGALP00000026310	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	M-protein, striated muscle; Is a structural constituent of myofibrillar M-band in striated muscle.	0.676
ACTN2	MYOT	ENSGALP00000054549	ENSGALP00000043545	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Myotilin.	0.688
ACTN2	MYOZ1	ENSGALP00000054549	ENSGALP00000008383	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Myozenin 1.	0.917
ACTN2	MYOZ2	ENSGALP00000054549	ENSGALP00000058841	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Uncharacterized protein.	0.786
ACTN2	MYOZ3	ENSGALP00000054549	ENSGALP00000067568	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Myozenin 3.	0.562
ACTN2	MYPN	ENSGALP00000054549	ENSGALP00000006242	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Myopalladin.	0.702
ACTN2	NEBL	ENSGALP00000054549	ENSGALP00000055172	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Nebulette.	0.454
ACTN2	NEBL-2	ENSGALP00000054549	ENSGALP00000047472	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Uncharacterized protein.	0.454
ACTN2	NEBL1	ENSGALP00000054549	ENSGALP00000065371	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Uncharacterized protein.	0.791
ACTN2	NRAP	ENSGALP00000054549	ENSGALP00000014482	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Nebulin related anchoring protein.	0.549
ACTN2	SMPX	ENSGALP00000054549	ENSGALP00000070524	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Uncharacterized protein.	0.559