STRINGSTRING
CXCR4 CXCR4 AMHR2 AMHR2 CCR9 CCR9 CCR8L CCR8L TGFBR2 TGFBR2 IL12RB2 IL12RB2 IL12A IL12A CHRDL1 CHRDL1 WFIKKN2 WFIKKN2 CSF1R CSF1R CER1 CER1 ACKR2 ACKR2 LOC107052104 LOC107052104 IL22RA1 IL22RA1 OSMR OSMR LIFR LIFR NOG NOG CSF3R CSF3R IL12B IL12B LRRC32 LRRC32 TSKU TSKU WFIKKN1 WFIKKN1 IL20RB IL20RB IL6ST IL6ST IL17F IL17F CSF2RA CSF2RA FZD4 FZD4 CHRDL2 CHRDL2 IL1RL1 IL1RL1 LOC418667 LOC418667 IFNGR1 IFNGR1 CCR6 CCR6 LEPR LEPR BMPR1B BMPR1B TGFB3 TGFB3 GREM1 GREM1 CCR10 CCR10 CXCR7 CXCR7 IL5RA IL5RA CXCR5 CXCR5 COPS5 COPS5 SOSTDC1 SOSTDC1 IL18R1 IL18R1 NOG2 NOG2 GHR GHR ACVR1 ACVR1 CCR8 CCR8 CCR7 CCR7 ENG ENG TNFRSF1A TNFRSF1A CHRD CHRD IL13RA2 IL13RA2 BMPER BMPER CCR4 CCR4 KIT KIT SOST SOST CCR5 CCR5 IL2RG IL2RG CXCR1 CXCR1 TGFBR1 TGFBR1 IL10RA IL10RA IFNAR1 IFNAR1 TNFRSF8 TNFRSF8 IL11RA IL11RA TNFRSF1B TNFRSF1B IL6R IL6R IL2RB IL2RB CX3CR1 CX3CR1 IL2RA IL2RA KLHL20 KLHL20 NBL1 NBL1 BMPR2 BMPR2 IL13RA1 IL13RA1 GMSRAL GMSRAL TNFRSF11A TNFRSF11A IL1R2 IL1R2 CD74 CD74 TWSG1 TWSG1 CD4 CD4 LOC112530337 LOC112530337 CNTFR CNTFR IL12RB1 IL12RB1 LOC101749641 LOC101749641 CRLF2 CRLF2 CRLF1 CRLF1 ACVRL1 ACVRL1 IL20RA IL20RA HAX1 HAX1 HJV HJV ACKR4 ACKR4 IL22RA2 IL22RA2 BMPR1A BMPR1A CCR2 CCR2 TNFRSF9 TNFRSF9 GREM2 GREM2 PRLR PRLR IL9R IL9R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CXCR4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (678 aa)
CCR9G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (382 aa)
CCR8LG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
IL12RB2Uncharacterized protein. (868 aa)
IL12AInterleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (203 aa)
CHRDL1Chordin-like protein 1; Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. (456 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (570 aa)
CSF1RUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
CER1Cerberus; Cytokine that acts as a regulator of the activity of Nodal/BMP pathways during the establishment of bilateral asymmetry in the head and trunk of the embryo; Belongs to the DAN family. (272 aa)
ACKR2Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (290 aa)
LOC107052104Uncharacterized protein. (680 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (592 aa)
OSMRUncharacterized protein. (622 aa)
LIFRUncharacterized protein. (1083 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling. Controls somitogenesis by sequestering the BMP-4 activity which in turn differentiates distinct subtypes of the mesoderm along the mediolateral axis. (387 aa)
CSF3RUncharacterized protein. (827 aa)
IL12BInterleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
LRRC32Uncharacterized protein. (708 aa)
TSKUTsukushin; Dorsalizing factor involved in the induction of Hensen node. Functions as an inhibitor of bone morphogenetic proteins (BMP) during gastrulation. (369 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (539 aa)
IL20RBInterleukin 20 receptor subunit beta. (312 aa)
IL6STGlycoprotein 130. (918 aa)
IL17FUncharacterized protein. (169 aa)
CSF2RAFibronectin type-III domain-containing protein. (384 aa)
FZD4Frizzled-4; Receptor for Wnt proteins (By similarity). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 ki [...] (525 aa)
CHRDL2Chordin like 2. (428 aa)
IL1RL1Uncharacterized protein. (532 aa)
LOC418667Fibronectin type-III domain-containing protein. (298 aa)
IFNGR1Uncharacterized protein. (442 aa)
CCR6G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
LEPRUncharacterized protein. (1148 aa)
BMPR1BBone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptiona (By similarity). Positively regulates chondrocyte differentiation. (502 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (535 aa)
GREM1Gremlin-1; Cytokine that may play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling. (184 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (361 aa)
CXCR7G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (364 aa)
IL5RAIL6Ra-bind domain-containing protein. (424 aa)
CXCR5Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa)
COPS5MPN domain-containing protein. (337 aa)
SOSTDC1Sclerostin domain-containing protein 1; Can activate or inhibit Wnt signaling in a context-dependent manner. Activates the canonical Wnt pathway whereby acts through Disheveled proteins and beta-catenin. Antagonises Wnt signaling through the canonical pathways presumably by blocking accessibility of certain WNTs to their receptors. Induces posterior neural markers via components of the canonical Wnt pathway; Belongs to the sclerostin family. (206 aa)
IL18R1Uncharacterized protein. (514 aa)
NOG2Noggin; Belongs to the noggin family. (207 aa)
GHRGrowth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. (646 aa)
ACVR1Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity). (524 aa)
CCR8G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (342 aa)
CCR7C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
ENGZP domain-containing protein. (714 aa)
TNFRSF1AUncharacterized protein. (427 aa)
CHRDUncharacterized protein. (1208 aa)
IL13RA2Uncharacterized protein. (391 aa)
BMPERCrossveinless-2. (678 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (358 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
SOSTSclerostin. (213 aa)
CCR5Chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (355 aa)
IL2RGFibronectin type-III domain-containing protein. (384 aa)
CXCR1Putative C-X-C chemokine receptor type 1, CXCR1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
IL10RAFibronectin type-III domain-containing protein. (558 aa)
IFNAR1Uncharacterized protein. (569 aa)
TNFRSF8TNFR-Cys domain-containing protein. (467 aa)
IL11RAUncharacterized protein. (423 aa)
TNFRSF1BUncharacterized protein. (462 aa)
IL6RUncharacterized protein. (445 aa)
IL2RBFibronectin type-III domain-containing protein. (576 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
IL2RAInterleukin-2 alpha receptor. (211 aa)
KLHL20Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity). (613 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1; May act as a tumor suppressor. (194 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (424 aa)
GMSRALFibronectin type-III domain-containing protein. (401 aa)
TNFRSF11ATNF receptor superfamily member 11a. (656 aa)
IL1R2Interleukin 1 receptor type 2. (412 aa)
CD74Invariant chain isoform p41. (286 aa)
TWSG1Twisted gastrulation protein homolog 1; May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity); Belongs to the twisted gastrulation protei [...] (224 aa)
CD4Uncharacterized protein. (487 aa)
LOC112530337Uncharacterized protein. (162 aa)
CNTFRCiliary neurotrophic factor receptor subunit alpha; Binds to CNTF (GPA). The alpha subunit provides the receptor specificity. (497 aa)
IL12RB1Fibronectin type-III domain-containing protein. (591 aa)
LOC101749641Fibronectin type-III domain-containing protein. (415 aa)
CRLF2Cytokine receptor like factor 2. (377 aa)
CRLF1Cytokine receptor like factor 1. (657 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (796 aa)
IL20RAInterleukin 20 receptor subunit alpha. (547 aa)
HAX1HCLS1 associated protein X-1. (315 aa)
HJVHemojuvelin BMP co-receptor. (514 aa)
ACKR4Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (385 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (239 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
CCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (354 aa)
TNFRSF9TNF receptor superfamily member 9. (269 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (168 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily. (831 aa)
IL9RFibronectin type-III domain-containing protein. (481 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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