STRINGSTRING
LCMT1 LCMT1 ATM ATM CDC16 CDC16 GEN1 GEN1 TTK TTK RIOK2 RIOK2 NDC80 NDC80 PSMG2 PSMG2 CDT1 CDT1 CENPE CENPE BUB1 BUB1 ZWILCH ZWILCH CDC23 CDC23 KLHL22 KLHL22 PLK1 PLK1 CUL3 CUL3 KNTC1 KNTC1 BCL7A BCL7A MAD1L1 MAD1L1 ANAPC7 ANAPC7 SPDL1 SPDL1 CDC27 CDC27 ENSGALP00000073167 ENSGALP00000073167 CDC26 CDC26 ENSGALP00000071775 ENSGALP00000071775 RB1 RB1 ENSGALP00000067477 ENSGALP00000067477 CDC6 CDC6 NSMCE2 NSMCE2 ZW10 ZW10 TPR TPR ZNF207 ZNF207 BUB1B BUB1B XRCC3 XRCC3 MAD2L1 MAD2L1 PCID2 PCID2 BUB3 BUB3 ENSGALP00000067038 ENSGALP00000067038 ANAPC15 ANAPC15 CDK5RAP2 CDK5RAP2 ENSGALP00000050074 ENSGALP00000050074 ANAPC4 ANAPC4 UBE2C UBE2C MAD2L1BP MAD2L1BP ANAPC5 ANAPC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (411 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
CDC16TPR_REGION domain-containing protein. (623 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (941 aa)
TTKTTK protein kinase. (880 aa)
RIOK2RIO domain-containing protein. (551 aa)
NDC80Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores t [...] (640 aa)
PSMG2Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (273 aa)
CDT1Chromatin licensing and DNA replication factor 1. (745 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2228 aa)
BUB1Uncharacterized protein. (1087 aa)
ZWILCHZwilch kinetochore protein. (536 aa)
CDC23Cell division cycle 23. (595 aa)
KLHL22BTB domain-containing protein. (638 aa)
PLK1Serine/threonine-protein kinase PLK. (595 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
KNTC1Rod_C domain-containing protein. (398 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (91 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (717 aa)
ANAPC7Anaphase promoting complex subunit 7. (565 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (608 aa)
CDC27Uncharacterized protein. (833 aa)
ENSGALP00000073167Cnn_1N domain-containing protein. (48 aa)
CDC26Uncharacterized protein. (84 aa)
ENSGALP00000071775RING-type domain-containing protein. (343 aa)
RB1Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
ENSGALP00000067477Uncharacterized protein. (178 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa)
NSMCE2SP-RING-type domain-containing protein. (239 aa)
ZW10Uncharacterized protein. (781 aa)
TPRTranslocated promoter region, nuclear basket protein. (2472 aa)
ZNF207Zinc finger protein 207. (479 aa)
BUB1BBUB1 N-terminal domain-containing protein. (1086 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (382 aa)
MAD2L1HORMA domain-containing protein. (206 aa)
PCID2PCI domain-containing protein. (399 aa)
BUB3WD_REPEATS_REGION domain-containing protein. (392 aa)
ENSGALP00000067038Uncharacterized protein. (384 aa)
ANAPC15Anaphase promoting complex subunit 15. (121 aa)
CDK5RAP2Uncharacterized protein. (751 aa)
ENSGALP00000050074Uncharacterized protein. (685 aa)
ANAPC4Anaphase promoting complex subunit 4. (838 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
MAD2L1BPMAD2L1 binding protein. (282 aa)
ANAPC5Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (756 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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